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    DRUG:

    CBP-1018

    i
    Other names: CBP-1018
    Associations

    News

    Trials
    Company:
    Coherent Biopharma
    Drug class:
    Tubulin inhibitor, PSMA inhibitor, Folate receptor 1 inhibitor
    Related drugs:
    Associations

    News

    Trials
    9ms
    Bispecific-XDC: Novel First-in-Class Cancer Therapies From Concept to Clinical (ADC-USA 2023)
    Describing CBP-1008: a FR/ TRPV6 targeted drug conjugate in Phase II pivotal studies of advanced ovarian cancer treatment; Exploring CBP-1018: a FR/ PSMA targeted drug conjugate in Phase Ib for prostate cancer therapy; Highlighting CBP-1019: TOP1i payload drug conjugate for unmet medical needs
    Clinical
    |
    TRPV6 (Transient Receptor Potential Cation Channel Subfamily V Member 6)
    |
    CBP-1008 • CBP-1018 • CBP-1019
    10ms
    CBP-1018, a bi-ligand-drug conjugate treated in patients with advanced solid tumors: A phase I, multi-center, open-label, dose-escalation and dose expansion study (ESMO 2023)
    Multiple SD and PSA decrease were observed at DLs of 0.08-0.14 mg/kg, conferred a promising preliminary antitumor activity in pts with mCRPC despite of COVID-19's impacts. MTD was not reached and dose-escalation to establish the RP2D is continuing.
    Clinical • Metastases
    |
    FOLR1 ( Folate receptor alpha )
    |
    CBP-1018