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    DRUG:

    CBA-1205

    i
    Other names: CBA-1205, LIV-1205
    Associations

    News

    Trials
    Company:
    Chiome Biosci
    Drug class:
    DLK1 inhibitor
    Related drugs:
    Associations

    News

    Trials
    1m
    A Phase I, First in Human Study of CBA-1205, Anti-DLK1 Monoclonal Antibody in Patients with Advanced Solid Tumors and Hepatocellular Carcinoma (HCC) (clinicaltrials.gov)
    P1, N=50, Recruiting, Chiome Bioscience Inc.
    New P1 trial
    |
    CBA-1205
    over1year
    Synergistic and long-lasing anti-tumor efficacy of CBA-1205, a novel glycoengineered humanized antibody targeting DLK-1, in combination with lenvatinib in human HCC xenograft models. (AACR 2023)
    Similar results were obtained with CBA-1205 at 1 mg/kg dosage in combination with lenvatinib at 10 mg/kg dosage in HepG2 xenograft model. In conclusion, we demonstrated synergistic and long-lasting anti-tumor efficacy of CBA-1205 in combination with lenvatinib in two different HCC pre-clinical models suggesting that the combination could be a new treatment option for unresectable advanced HCC.
    Preclinical • Combination therapy
    |
    EGF (Epidermal growth factor)
    |
    Lenvima (lenvatinib) • CBA-1205