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    BIOMARKER:

    CAV1 overexpression + CAV2 overexpression

    i
    Other names: CAV1, CAV, Caveolin 1, caveolae protein, 22kDa, CAV2, Caveolin 2, CAV, Caveolin-2, Caveolae Protein, 20-KD
    Entrez ID:
    857; 858
    Related biomarkers:
    Expression
    Others
    1year
    Caveolin gene expression predicts clinical outcomes for early-stage HER2-negative breast cancer treated with paclitaxel-based chemotherapy in the GeparSepto trial. (PubMed, Clin Cancer Res)
    Our findings indicate high CAV1/2 expression is associated with worse DFS and OS in paclitaxel-treated patients. Conversely, in nab-paclitaxel-treated patients, high CAV1/2 expression is associated with increased pCR and no significant detriment to DFS or OS compared to low CAV1/2 expression.
    Clinical data • Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • CAV2 (Caveolin 2)
    |
    HER-2 negative • CAV1 overexpression • CAV1 expression • CAV1 overexpression + CAV2 overexpression
    |
    albumin-bound paclitaxel • cyclophosphamide • epirubicin