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    GENE:

    CASP8AP2 (Caspase 8 Associated Protein 2)

    i
    Other names: CASP8AP2, Caspase 8 Associated Protein 2, FLASH, RIP25, FLICE-Associated Huge Protein, KIAA1315, CED-4, CASP8-Associated Protein 2, FLJ11208, CASP8 Associated Protein 2, FLICE Associated Huge, FLASH Homolog RIP25, Human FLASH
    Associations

    News

    Trials
    2ms
    Prognostic significance of caspase 8 associated protein 2 (CASP8AP2) in childhood b cell acute lymphoblastic Leukemia. (PubMed, Discov Oncol)
    Higher initial CASP8AP2 gene expression was associated with favorable impact on event-free survival in pediatric ALL patients. Post-induction levels did not show similar correlation. Future larger studies are needed to confirm the favorable association and to search for other possibly related prognostic factors to further refine risk stratification.
    Journal
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    CASP8 (Caspase 8) • CASP8AP2 (Caspase 8 Associated Protein 2)
    1year
    Predicting prognosis in lung adenocarcinoma by predicting TIGIT expression: a pathomics model. (PubMed, J Thorac Dis)
    Increased abundance of G2/M checkpoint-related genes (MARCKS, CASP8AP2) and infiltration of CD8+ T cells and M2 macrophages were noted in the high PS group (P<0.05). TIGIT expression is significantly correlated with LUAD prognosis and can effectively predict patient outcomes.
    Journal • IO biomarker
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    CD8 (cluster of differentiation 8) • LAG3 (Lymphocyte Activating 3) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • ICOS (Inducible T Cell Costimulator) • TGFB1 (Transforming Growth Factor Beta 1) • IL15 (Interleukin 15) • CASP8AP2 (Caspase 8 Associated Protein 2) • MARCKS (Myristoylated Alanine Rich Protein Kinase C Substrate) • WIPF1 (WAS/WASL Interacting Protein Family Member 1)
    over1year
    Bioprobe-RNA-seq-microRaman system for deep tracking of the live single-cell metabolic pathway chemometrics. (PubMed, Biosens Bioelectron)
    While PC-thymol (THY) induces the lysophospholipase-2 (LYPLA2) (p-value = 0.009) and acetylneuraminate-9-O-acetyltransferase (CASD1) (p-value = 0.022) at 1143.19 cm-1. our findings establish a new concept to promote the cross-disciplinary use of instant cellular-based detection technology for intermediary evaluating the signaling cellular transcriptome.
    Journal
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    CASP8 (Caspase 8) • FTL (Ferritin Light Chain) • CASP8AP2 (Caspase 8 Associated Protein 2)
    almost2years
    Genomic imbalances analysis provides new insight into prognostic factors in adult and pediatric T-ALL. (PubMed, Blood)
    Genomic complexity, del(16)(p13)/CREBBP and gain at 6q27 involving MLLT4 maintained their significance in multivariate analysis for survival outcome. Our study thus demonstrated that whole genome analysis of imbalances provides new insights to refine risk stratification in T-ALL.
    Journal
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    CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • RB1 (RB Transcriptional Corepressor 1) • NF1 (Neurofibromin 1) • ETV6 (ETS Variant Transcription Factor 6) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • CREBBP (CREB binding protein) • PTPN2 (Protein Tyrosine Phosphatase Non-Receptor Type 2) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • CDKN1B (Cyclin dependent kinase inhibitor 1B) • AFDN (Afadin, Adherens Junction Formation Factor) • CASP8AP2 (Caspase 8 Associated Protein 2) • SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit) • RPL22 (Ribosomal Protein L22)
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    Chr del(13)(q14)
    over2years
    Dual role of CASP8AP2/FLASH in regulating epithelial-to-mesenchymal transition plasticity (EMP). (PubMed, Transl Oncol)
    The ZEB1/SNAIL/E-cadherin phenotype described in FLASH-depleted cancer cells is driving a hybrid E/M phenotype in which epithelial and mesenchymal markers coexist.
    Journal
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    CDH1 (Cadherin 1) • TGFB1 (Transforming Growth Factor Beta 1) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • CASP8AP2 (Caspase 8 Associated Protein 2)
    over2years
    Chromothripsis and Genomic Complexity As Pejorative Prognostic Markers in Pediatric and Adult T-ALL (ASH 2023)
    Our study demonstrated that the whole genome analysis of imbalances provides new insights to refine the risk stratification in T-ALL. Notably, genomic complexity (≥ 15 genomic imbalances) and chromothripis demonstrated an association with an inferior outcome in terms of EFS and CIR in pediatric and adult T-ALL.
    Clinical
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    CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • RB1 (RB Transcriptional Corepressor 1) • NF1 (Neurofibromin 1) • ETV6 (ETS Variant Transcription Factor 6) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • CREBBP (CREB binding protein) • PTPN2 (Protein Tyrosine Phosphatase Non-Receptor Type 2) • SH2B3 (SH2B Adaptor Protein 3) • CDKN1B (Cyclin dependent kinase inhibitor 1B) • AFDN (Afadin, Adherens Junction Formation Factor) • CASP8AP2 (Caspase 8 Associated Protein 2) • SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit) • RPL22 (Ribosomal Protein L22)
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    Chr del(13)(q14) • Chr del(1p)
    over3years
    CRISPRi screening identifies CASP8AP2 as an essential viability factor in lung cancer controlling tumor cell death via the AP-1 pathway. (PubMed, Cancer Lett)
    Furthermore, inhibition of AP-1 reverted the CASP8AP2 silencing-induced phenotype. Overall, the tailored CRISPRi screen profiled the impact of over 2000 genes on the survival of eight LUAD cell lines and identified the CASP8AP2 - AP-1 axis mediating lung cancer viability.
    Journal
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    CASP8AP2 (Caspase 8 Associated Protein 2)