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    BIOMARKER:

    CASP8 overexpression

    i
    Other names: CASP8, Casp-8, FLICE, MACH, MCH5, Caspase 8
    Entrez ID:
    841
    over2years
    The Relationship of Pyroptosis-Related Genes, Patient Outcomes, and Tumor-Infiltrating Cells in Bladder Urothelial Carcinoma (BLCA). (PubMed, Front Pharmacol)
    Our data suggest that PRGs, especially CASP8, showed strong associations with patient outcomes and TICs in BLCA. If validated, these results could potentially aid in the prognostication and guide treatment in BLCA patients.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • PD-1 (Programmed cell death 1) • CD4 (CD4 Molecule) • IL7R (Interleukin 7 Receptor) • CASP8 (Caspase 8)
    |
    CASP8 overexpression • IL7R expression
    over2years
    Caspase 8 Expression Patterns in Meningiomas: A Tissue Microarray Digital Image Analysis. (PubMed, Cureus)
    Caspase 8 aberrant expression is observed in meningiomas associated with their differentiation grade and mitotic activity. Targeted therapeutic strategies focused on enhancing caspase 8 expression and also inducing the overall apoptotic activity should be a very promising approach in rationally handling sub-groups of meningioma patients.
    Journal
    |
    CASP8 (Caspase 8)
    |
    CASP8 overexpression
    3years
    Antioxidant and antiproliferative potential of ethanolic extracts from Moringa oleifera, Tropaeolum tuberosum and Annona cherimola in colorrectal cancer cells. (PubMed, Biomed Pharmacother)
    In addition, we observed cell death by autophagy in M. oleifera and T. tuberosum extracts. Therefore, these ethanolic extracts are excellent candidates for future molecular analysis of the presence of bioactive compounds and in vivo studies which could improve colon cancer therapy.
    Journal
    |
    CASP8 (Caspase 8) • CASP9 (Caspase 9)
    |
    CASP8 overexpression
    |
    5-fluorouracil
    3years
    Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation. (PubMed, Cell Death Dis)
    Moreover, high caspase-8 expression was correlated with a worse prognosis in prostate cancer patients. Collectively, our work demonstrates that enzalutamide-resistance is mediated by caspase-8 upregulation and the consequent increase in NF-κB/IL-8 mediated survival signaling, highlighting caspase-8 and NF-κB as potential therapeutic targets to overcome enzalutamide-resistance in CRPC.
    Journal
    |
    CXCL8 (Chemokine (C-X-C motif) ligand 8) • CASP8 (Caspase 8)
    |
    CASP8 overexpression
    |
    Xtandi (enzalutamide capsule)