CASP6 (Caspase 6, apoptosis-related cysteine peptidase)

Etoposide was used as a reference in characterization, release, and loading studies...Plain liposomes exhibited minimal cytotoxicity, confirming their biocompatibility. Liposomal bromophenol, which we have introduced to the literature for the first time, is expected to be a promising nanocarrier system that could be effective in cancer treatment by improving the therapeutic index of new drug candidates such as marine bromophenols.

These observations imply that apoptosis induction by 14t in MCF-7 systems operates through dual intrinsic and extrinsic cascades, whereas 14n principally initiates apoptotic mechanisms via the extrinsic route. Conclusively, integration of indole-piperazine moieties into alepterolic acid scaffolds constitutes a viable tactical framework for generating innovative therapeutic candidates.

The toxicity is mitigated in ZBP1-knockout mice. This study unveils a mechanism that dictates cell fate during DDR inhibitors-induced aberrant mitosis, emphasizing the critical balance between efficacy and safety in optimizing DDR inhibitors combination therapies.

Lentiviral overexpression of Homer1a reduced pain hypersensitivity and concurrently inhibited the caspase-6/tumor necrosis factor-alpha signaling pathway.ConclusionsThe present study demonstrates that Homer1a activation suppresses the caspase-6/tumor necrosis factor-alpha signaling pathway and alleviates thermal hypersensitivity in a rat model of inflammatory pain. These findings suggest that the Homer1a/caspase-6 signaling axis may represent a promising therapeutic target for inflammatory pain management.

These results establish NiCo₂O₄ as a dual-function nanomaterial-both cytotoxic and chemosensitizing-capable of amplifying doxorubicin efficacy via mitochondrial and caspase-dependent pathways. Its synergistic activity and favorable selectivity highlight the translational potential of NiCo₂O₄-based nanochemosensitization strategies.

Compound 10e showed the best mean growth inhibition percentage (GI%) of 64.60% compared with the FDA-approved doxorubicin (Dox)...Finally, the molecular docking study against Caspase 6 demonstrated eligible binding affinities of the examined analogs. Overall, this study demonstrated that the synthesized compounds are promising apoptotic inducers and possess great potential as anticancer drugs.

Gene expression results indicated that the combination treatment significantly upregulated CASP6 and BAX, while downregulating BCL2, confirming enhanced apoptosis. NiFe₂O₄ nanoparticles potentiate the anticancer activity of doxorubicin in A549 cells at lower doses, suggesting a promising strategy to enhance efficacy while potentially reducing chemotherapeutic side effects.

These findings suggest that the caspase-6 pathway has the potential to be developed as a novel treatment for DLBCL. Further research is needed to explore the clinical application of PPI in lymphoma treatment and its potential synergies with other drugs.

In this study, we investigated the effects of conventional chemotherapeutics, Cisplatin and 5-fluorouracil (5-FU), in combination with small molecule inhibitors (SMIs) targeting the PI3K/AKT signaling pathway, on NSCLC cell viability...Dose-response analyses were performed to determine the optimal concentrations of Cisplatin, 5-FU, the AKT inhibitor MK2206, and the PI3K inhibitor BKM120, both as monotherapies and in combination treatments...Mechanistic studies revealed that apoptosis induction was mediated through the apoptotic pathway regulated by the Bcl-2 family and activation of caspase-3 and caspase-6. These findings highlight the therapeutic potential of combining PI3K/AKT inhibitors with conventional chemotherapy to overcome resistance mechanisms in NSCLC.

Finally, co-administration of ZNG with SA reduced SA-induced cardiac histopathological changes in rats. The results of this study suggest that ZNG may provide an alternative for clinical inflammation control through antioxidant and anti-inflammatory activities.

Besides, the upstream TF network of the 7 differentiated expressed pyroptosis-related key genes was constructed. Our team developed a diagnostic model for pyroptosis-related signatures in Alzheimer's disease, investigating ceRNA and TF regulatory networks, which may facilitate the diagnosis of AD with blood-based biomarkers.

Its high biocompatibility (SWISS-ADME) and strong molecular interactions support its potential as a novel therapeutic agent for OSCC. This integrative approach provides valuable insights into DET's mechanism of action, paving the way for pre-clinical and clinical applications.