CASP3 (Caspase 3)

The p38 MAPK inhibitor SB202190 reversed ORI-induced effects on cell death, cell migration and invasion, and apoptosis, highlighting the critical role of the p38 MAPK/p53 pathway. ORI effectively suppressed subcutaneous tumour growth in nude mice without notable toxicity while upregulating apoptosis-related proteins Bax and cleaved caspase-3 and downregulating Bcl-2 through activation of the p38 MAPK/p53 pathway.

These observations coincided with the restoration of mitochondrial integrity and mitophagy. Taken together, these findings identify RA metabolism as a key regulatory node in astrocyte reactivity and suggest a potential therapeutic role for RA in neuroinflammatory conditions.

The tumor-driven proliferation of aggressive LSC clones, caused by dysregulated self-renewal, leads to highly proliferative tumor masses. The current findings showed that the cells couldn't recover from chronic, persistent B[a]P-induced damage, even at the lowest tested concentrations, leading to irreversible and invasive lesions.

In addition, TNFSF10-mediated PANoptosis may facilitate preeclampsia progression by promoting inflammation through NK cell activation and M1 macrophage polarization at the maternal-fetal interface. Our findings not only establish TNFSF10 as a critical mediator of placental PANoptosis, but also reveal its dual role in coordinating trophoblast cell death and immune dysregulation, suggesting novel therapeutic strategies targeting preeclampsia.

Nano-formulated curcumin demonstrates strong, multi-target anticancer activity by blocking cell growth and angiogenesis while promoting apoptosis. These findings support its potential as a safe and effective therapeutic option for breast cancer.

ASO treatment against mutated H-ras showed better therapeutic efficacy than ASO treatment against c-raf.1. Thus, blocking mutated H-ras than c-raf.1 might appreciably influence HCC inhibition in rats.

However, TRG therapy restored renal impairments via regulating antioxidative, anti-apoptotic, anti-inflammatory, and histo-architecture. Our findings were strongly supported by in-silico findings that demonstrated the potential binding of TRG with key regulatory genes.

Importantly, YHD enhanced the sensitivity of OS cells to cisplatin, demonstrating a synergistic inhibitory effect in vitro and in an orthotopic OS mouse model. These findings suggest that YHD exerts its anti-osteosarcoma effects via reactive oxygen species-mediated mitochondrial disruption and pathway modulation, and may serve as a promising adjuvant to conventional chemotherapy.

These results suggest that E-BVL may influence apoptotic and proliferative pathways in THP-1 leukemia cells. Overall, this study highlights B. vulgaris leaf extract as a promising natural source of bioactive compounds for anti-leukemic research, without specifically implicating berberine, which was not detected in the extract.

THSWD soaking effectively mitigates sorafenib-induced HFSR, in rat model. By regulating RAGE/PI3K/AKT signaling to coordinate keratinocyte apoptosis and autophagy, THSWD promotes holistic restoration of skin barrier structure and function. These findings revealled the potential mechanism of THSWD topically treating VEGFR-TKI-induced HFSR.

JC-1 staining showed the obvious MMP depolarization, and Western blot illustrated the increased expression of caspase-3 and Bax/Bcl-2 ratio during the cell apoptosis process. This study highlights the potential of GCP@NBs as novel and highly effective nanoplatforms for treatment of PDAC.

Functionally, FD-AgNPs significantly decreased HeLa cell viability in a dose-dependent manner (p < 0.001), exhibiting stronger cytotoxic effects at 5 and 10 μg/mL than cisplatin...Overall, these findings demonstrate that FD-AgNPs exert potent anticancer effects by simultaneously inhibiting proliferation and promoting apoptosis in cervical cancer cells. The integration of green synthesis, detailed physicochemical characterization, and mechanistic biological evaluation underscores the potential of FD-AgNPs as a promising plant-based nanotherapeutic approach for cervical cancer treatment.