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BIOMARKER:

CASP3 overexpression

i
Other names: CASP3, apopain, CPP32, CPP32B, Yama, Caspase 3
Entrez ID:
Related biomarkers:
17d
Salvia officinalis L. exerts oncostatic effects in rodent and in vitro models of breast carcinoma. (PubMed, Front Pharmacol)
In vitro analyses revealed significant anti-cancer effects of SPGE extract in MCF-7 and MDA-MB-231 cell lines (cytotoxicity, caspase-3/-7, Bcl-2, Annexin V/PI, cell cycle, BrdU, and mitochondrial membrane potential). Our study demonstrates the significant chemopreventive and treatment effects of salvia haulm using animal or in vitro BC models.
Preclinical • Journal • IO biomarker
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PTEN (Phosphatase and tensin homolog) • BCL2 (B-cell CLL/lymphoma 2) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • MIR155 (MicroRNA 155) • EPCAM (Epithelial cell adhesion molecule) • MIR21 (MicroRNA 21) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • MIR34A (MicroRNA 34a-5p) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • TGFB1 (Transforming Growth Factor Beta 1) • CASP7 (Caspase 7) • MIR210 (MicroRNA 210) • RASSF1 (Ras Association Domain Family Member 1) • ANXA5 (Annexin A5) • MIR145 (MicroRNA 145) • MIR22 (MicroRNA 22) • TIMP3 (TIMP Metallopeptidase Inhibitor 3)
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BAX expression • CASP3 overexpression • BAX overexpression • EPCAM expression
2ms
Potential Gastric Cancer Immunotherapy: Stimulating the Immune System with Helicobacter pylori pIRES2-DsRed-Express-ureF DNA Vaccines. (PubMed, Arch Immunol Ther Exp (Warsz))
The more excellent ratios of infiltrating CD8+/CD4+ T cells, the decreased invasion of regulatory FOXP3+ Treg lymphocytes, and the increased apoptosis brought on by Caspase9/Caspase-3 overexpression and Survivin downregulation may all contribute to the consequences. Our findings suggest that in people with advanced GC, H. pylori pIRES2-DsRed-Express-ureF DNA vaccines may have immunotherapeutic utility.
Journal • IO biomarker
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CD8 (cluster of differentiation 8) • BIRC5 (Baculoviral IAP repeat containing 5) • CD4 (CD4 Molecule) • CASP3 (Caspase 3) • FOXP3 (Forkhead Box P3)
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CASP3 overexpression
2ms
Journal • IO biomarker
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MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • ANXA5 (Annexin A5) • BATF3 (Basic Leucine Zipper ATF-Like Transcription Factor 3)
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BCL2 expression • MYC expression • BAX expression • CASP3 overexpression
3ms
Irradiation Induces Gasdermin E-Triggered Tumor Immunity to Inhibit Esophageal Carcinoma Cell Survival. (PubMed, ACS Omega)
Overexpression of caspase-3 and GSDME accelerated irradiation-induced ICD. In summary, irradiation in EC cells induces GSDME-mediated pyroptosis and activates ICD to inhibit esophageal carcinoma cell survival.
Journal
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CASP3 (Caspase 3) • HMGB1 (High Mobility Group Box 1) • ANXA5 (Annexin A5) • GSDME (Gasdermin E) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1)
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CASP3 overexpression
7ms
Structural changes and anti-hepatocellular carcinoma activity of interferon-γ after interaction with sinensetin. (PubMed, Int J Biol Macromol)
Cellular assays revealed a synergistic effect of sinensetin on IFNγ -triggered anticancer action in HepG2 cells through overexpression of caspase-3 mRNA and protein. In conclusion, this study may hold great promise for the development of potential ligand- protein complexes for therapeutic purposes.
Journal
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IFNG (Interferon, gamma) • CASP3 (Caspase 3)
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CASP3 overexpression
8ms
Ononin Relieves the Thyroid Cancer Progression through Targeting the Caspase 3 and CD274 Expression Levels. (PubMed, Biol Pharm Bull)
What is more, CASP3 overexpression or CD274 knockdown promoted the role of ononin in TC cells. Ononin treatment induced the cell death of the TC cells through regulating the CASP3 and CD274 expressions.
Journal
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PD-L1 (Programmed death ligand 1) • CASP3 (Caspase 3)
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PD-L1 expression • CASP3 overexpression
8ms
Ipconazole Induces Oxidative Stress, Cell Death, and Proinflammation in SH-SY5Y Cells. (PubMed, Toxics)
In addition, ipconazole at 50 µM induced an overexpression of Bax, Casp3, APAF1, and BNIP3 (cell death genes); NLRP3, Casp1, and IL1B (inflammasome complex genes); and NFκB, TNFα, and IL6 (inflammation genes); it also reduced the expression of NRF2, SOD, and GPx (antioxidant genes). Our results show that ipconazole produces cytotoxic effects by reducing cell viability, generating oxidative stress, and inducing cell death in SH-SY5Y cells, so ipconazole exposure should be considered as a factor in the presentation of neurotoxicity or neurodegeneration.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CASP7 (Caspase 7) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • APAF1 (Apoptotic peptidase activating factor 1)
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BAX expression • CASP3 overexpression
1year
The signature of pyroptosis-related gene prognostic and immune microenvironment in adrenocortical carcinoma. (PubMed, Front Mol Biosci)
In conclusion, we established a prognostic model of PRG characteristics in ACC and analyzed the relationship between PRGs and immune infiltration. Through our study, it may be helpful to find the mechanism of pyroptosis in ACC.
Journal • Tumor mutational burden • IO biomarker
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TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • CASP3 (Caspase 3) • CASP9 (Caspase 9) • PRKACA (Protein Kinase CAMP-Activated Catalytic Subunit Alpha)
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CASP3 overexpression
over1year
Design and Synthesis of Novel Phenylahistin Derivatives Based on Co-Crystal Structures as Potent Microtubule Inhibitors for Anti-Cancer Therapy. (PubMed, Mar Drugs)
Phenylahistin is a naturally occurring marine product with a diketopiperazine structure that can bind to the colchicine site of microtubulin as a possible anticancer agent. Importantly, the continuous administration of 15p resulted in a lower toxicity than that of docetaxel (10 mg/kg) and cyclophosphamide (20 mg/kg). Overall, the novel allyl-imidazole-diketopiperazine-type derivatives could be considered safe and effective potential agents for cancer treatment.
Journal
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CASP3 (Caspase 3)
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CASP3 overexpression
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docetaxel • cyclophosphamide
over1year
Development of New Natural Lipid-Based Nanoparticles Loaded with Aluminum-Phthalocyanine for Photodynamic Therapy against Melanoma. (PubMed, Nanomaterials (Basel))
The exposed phospholipid phosphatidylserine was identified, and the treatment triggered a high expression of Caspase 3. A stable Amazon butter-based SLN-AlPc formulation was developed, which exhibits strong in vitro photodynamic activity on melanoma cells.
Journal
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CASP3 (Caspase 3)
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CASP3 overexpression
over1year
Liposomes Loaded with Amaranth Unsaponifiable Matter and Soybean Lunasin Prevented Melanoma Tumor Development Overexpressing Caspase-3 in an In Vivo Model. (PubMed, Pharmaceutics)
In addition, larger tumors showed larger necrotic areas (38% with respect to the total tumor) (p < 0.0001). In conclusion, the UM + LunLip treatment was effective when applied either subcutaneously or topically in the melanoma tumor-developing groups, as it slowed down cell proliferation and activated apoptosis.
Preclinical • Journal
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CASP3 (Caspase 3)
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CASP3 overexpression
over1year
Design, synthesis and mechanistic studies of novel imidazo[1,2-a]pyridines as anticancer agents. (PubMed, Bioorg Chem)
Also, compound 8c was able to induce caspase-3 overexpression (6.98 folds), if compared to control. Finally, molecular docking studies and physicochemical properties calculation of compounds 8b, 8c, 9e and 9f were carried out to explain the biological data and to predict bioavailability of the most active compounds.
Journal
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CASP3 (Caspase 3)
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CASP3 overexpression
over1year
In Vivo Distribution and Therapeutic Efficacy of Radioiodine-Labeled pH-Low Insertion Peptide Variant 3 in a Mouse Model of Breast Cancer. (PubMed, Mol Imaging)
The I-Var 3-pHLIP group presented a lower expression of Ki67 and a higher expression of caspase 3. Radioiodine-labeled Var3-pHLIP effectively targeted BC cells in an acidic environment and inhibited the growth of MDA-MB-231 xenografts by ionizing radiation.
Preclinical • Journal
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CASP3 (Caspase 3)
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CASP3 overexpression
almost2years
Light-Activated Monomethyl Auristatin E Prodrug Nanoparticles for Combinational Photo-Chemotherapy of Pancreatic Cancer. (PubMed, Molecules)
In clinic, the most effective approach to treat pancreatic cancers is the combination treatment of several chemotherapeutic drugs, including fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX), but this approach is not adequate to manage patients due to their severe toxic side effects. The CDM directly (intratumoral) injected into pancreatic cancers in orthotopic models through an invasive approach significantly delayed the tumor progression by combinational photo-chemotherapy with less toxic side effects. This study offers a promising and alternative approach for safe and more effective pancreatic cancer treatment via prodrug nanoparticles that combine photodynamic therapy and chemotherapy.
Journal
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CASP3 (Caspase 3)
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CASP3 overexpression
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5-fluorouracil • oxaliplatin • irinotecan • leucovorin calcium
almost2years
BDH2 promotes apoptosis and autophagy of lung adenocarcinoma cells via Akt/mTOR pathway. (PubMed, Gen Physiol Biophys)
Phosphorylation of AKT and mTOR in lung adenocarcinoma cells were reduced by BDH2 over-expression. In conclusion, BDH2 functioned as a tumor suppressor in lung adenocarcinoma through promotion of Akt/mTOR-mediated cell apoptosis and autophagy.
Journal
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BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • BECN1 (Beclin 1)
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BAX expression • CASP3 overexpression
almost2years
Human umbilical vein endothelial cells-derived exosomes enhance cardiac function after acute myocardial infarction by activating the PI3K/AKT signaling pathway. (PubMed, Bioengineered)
The low expression levels of Bcl-2-associated X protein (Bax) and cleaved caspase-3, high expression levels of B-cell lymphoma 2 (Bcl-2), phosphorylated phosphatidylinositol 3-kinase (p-PI3K), and phosphorylated protein kinase B (p-AKT) were detected in AMI mouse models treated with HUVECs-derived exosomes in-vivo. In conclusion, HUVECs-derived exosomes effectively enhanced cardiac function after AMI and inhibited cardiomyocyte apoptosis, which might be regulated through the phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (AKT) signaling pathway.
Journal • IO biomarker
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BAX (BCL2-associated X protein) • CASP3 (Caspase 3)
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BCL2 expression • BAX expression • CASP3 overexpression
2years
The relationship between the efficacy of talazoparib and the functional toll-like receptors 3 and 9 in triple negative breast cancer. (PubMed, Mol Immunol)
Additionally, TAL combined with Poly I:C or CpG-ODN more increased TLR3, TLR9 and IRF7 protein levels in HCC1937 cells and treatment with TAL and Poly I:C had greater potential for overcoming TAL resistance. In conclusion, the combination of PARPi with TLR agonists may be a new therapeutic combined strategy for the effective immunotherapy of TNBC.
Clinical • Journal • PARP Biomarker • IO biomarker
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CASP3 (Caspase 3) • CASP8 (Caspase 8) • TLR3 (Toll Like Receptor 3) • IRF7 (Interferon Regulatory Factor 7)
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CASP3 overexpression
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Talzenna (talazoparib)
over2years
Self-Propelled Asymmetrical Nanomotor for Self-Reported Gas Therapy. (PubMed, Small)
Fluorescein isothiocyanate (FITC) is conjugated onto the surface of Au via caspase-3 responsive peptide (DEVD) and the therapeutic process of gas therapy can be optically self-reported by the fluorescence of FITC that is turned on in the presence of overexpressed caspase-3 as an apoptosis indicator. Au@MnO nanomotors show self-reported therapeutic efficacy and high biocompatibility both in vitro and in vivo, offering important new insights to the design and development of novel nanomotors for efficient payload delivery into deep tumor tissue and in situ monitoring of the therapeutic process.
Journal
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CASP3 (Caspase 3)
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CASP3 overexpression
over2years
Evaluation of a procaspase-3 activator with hydroxyurea or temozolomide against high-grade meningioma in cell culture and canine cancer patients. (PubMed, Neuro Oncol)
Our results suggest PAC-1 + TMZ as a potentially efficacious combination for the treatment of human meningioma, and also demonstrate the utility of including pet dogs with meningioma as a means to assess anticancer strategies for this common brain tumor.
Preclinical • Journal
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CASP3 (Caspase 3)
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CASP3 overexpression
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temozolomide • hydroxyurea • PAC-1