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    GENE:

    CASP10 (Caspase 10)

    i
    Other names: CASP10, Caspase 10, MCH4, FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2, FLICE-2, Caspase 10, Apoptosis-Related Cysteine Protease, ICE-Like Apoptotic Protease 4, Caspase-10, CASP-10, FLICE2, Caspase 10, Apoptosis-Related Cysteine Peptidase, Caspase 10 Apoptosis-Related Cysteine Peptidase, Interleukin-1B-Converting Enzyme 2, Apoptotic Protease MCH-4, Apoptotic Protease Mch-4, FADD-Like ICE2, ALPS2
    Associations

    News

    Trials
    14d
    pH-Responsive ZIF-8 Precisely Induces Apoptosis of Oral Squamous Cell Carcinoma over Orofacial Mesenchymal Stem Cells. (PubMed, Pharmaceutics)
    Objectives: pH-responsive zeolite imidazolate framework-8 (ZIF-8) enables selective release of 5-fluorouracil (5-FU) within the acidic tumor microenvironment...Apoptosis-related signaling was also elevated in SCC7 cells compared with DPSCs. ZIF-8 at 100 μg/mL selectively inhibits SCC7 growth while sparing OMSC viability and apoptosis.
    Journal
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    BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CASP6 (Caspase 6, apoptosis-related cysteine peptidase) • CASP10 (Caspase 10)
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    5-fluorouracil
    15d
    Molecular subtyping of small-cell lung cancer in clinical practice: Primary tumor-lymph node concordance, intratumoral heterogeneity, and genomic context in a Chinese cohort. (PubMed, Lung Cancer)
    The observed discordance during regional nodal dissemination suggests that single site-dependent immunohistochemistry-based subtyping may be insufficient. Future frameworks incorporating multi-region analysis and liquid biopsy are essential to capture the dynamic evolution of SCLC and optimize personalized management for localized disease.
    Journal
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    TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • RB1 (RB Transcriptional Corepressor 1) • NOTCH1 (Notch 1) • KMT2D (Lysine Methyltransferase 2D) • SLFN11 (Schlafen Family Member 11) • CREBBP (CREB binding protein) • YAP1 (Yes associated protein 1) • NFIB (Nuclear Factor I B) • POU2F3 (POU Class 2 Homeobox 3) • ASCL1 (Achaete-Scute Family BHLH Transcription Factor 1) • CASP10 (Caspase 10) • INSM1 (INSM Transcriptional Repressor 1) • NEUROD1 (Neuronal Differentiation 1)
    2ms
    HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer. (PubMed, Cell Rep Med)
    Notably, recombinant TRAIL protein synergizes with SGI1027 or MS1129 to kill VHL-deficient ccRCC in mice. Collectively, our study unveils an apoptosis induction strategy that involves hijacking HIFs for ccRCC treatment.
    Journal
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    DNMT3A (DNA methyltransferase 1) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • DNMT1 (DNA methyltransferase 1) • DNMT3B (DNA Methyltransferase 3 Beta) • CASP10 (Caspase 10) • CASP1 (Caspase 1)
    2ms
    Atranorin Triggers Intrinsic and Extrinsic Apoptosis and Suppresses Migration in Human Melanoma Cells. (PubMed, Curr Med Chem)
    This study is the first to demonstrate the potent anti-melanoma effect of atranorin. This demonstrates the natural compounds' effects on cell proliferation, cell cycle progression, and the suppression of metastasis. These findings emphasize the potential of atranorin as a novel natural compound for use in adjunctive or targeted melanoma therapy, and highlight the need for further preclinical and clinical evaluation.
    Journal • PARP Biomarker • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • MCL1 (Myeloid cell leukemia 1) • BIRC5 (Baculoviral IAP repeat containing 5) • PARP1 (Poly(ADP-Ribose) Polymerase 1) • FADD (Fas associated via death domain) • CASP3 (Caspase 3) • CASP9 (Caspase 9) • ANXA5 (Annexin A5) • APAF1 (Apoptotic peptidase activating factor 1) • CASP10 (Caspase 10)
    3ms
    Design, Synthesis, Molecular Docking, Dynamics Simulation, and Biological Evaluation of Novel Thiazolidinedione Derivatives Against Breast Cancer with Apoptosis-Inducing Activity. (PubMed, ACS Omega)
    The cytotoxic activity of the synthesized compounds was evaluated against MCF-7 breast cancer cells, revealing IC50 values of 29.44 μM for PZ-9 and 17.35 μM for PZ-11, compared to 6.45 μM for the reference drug vincristine...PZ-11 is a promising TZD-based anticancer drug candidate against breast cancer cells, as determined by computational and experimental analysis. However, further validation is required through in vivo analysis to support these findings.
    Journal
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    BIRC3 (Baculoviral IAP repeat containing 3) • AIF1 (Allograft Inflammatory Factor 1) • CASP10 (Caspase 10)
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    vincristine
    5ms
    Cross-tissue transcriptome-wide association studies identify genetic susceptibility genes for prostate cancer. (PubMed, BMC Cancer)
    This study identified 13 new susceptibility genes significantly associated with PCa risk and provided new insights into the genetic basis of PCa, contributing to a more comprehensive understanding of its complex genetic structure.
    Journal
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    RIF1 (Replication Timing Regulatory Factor 1) • CASP10 (Caspase 10)
    5ms
    Prognostic model for pediatric brain tumors based on tumor microenvironment-specific gene signatures. (PubMed, Discov Oncol)
    The TME-specific gene-based prognostic model effectively predicts survival outcomes in pediatric brain tumors, offering promising biomarkers for personalized medicine and potential therapeutic targets. However, further research is required to validate these findings across different tumor subtypes and to explore their clinical applications.
    Journal • Gene Signature
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    ITGAX (Integrin Subunit Alpha X) • CASP10 (Caspase 10) • EPSTI1 (Epithelial Stromal Interaction 1)
    7ms
    "NO" Means Yes: Unlocking the Therapeutic Synergy of Nitric Oxide (NO) and Chlorambucil (Cbl) via Photoresponsive Sequential Delivery in a Triple-Negative Breast Cancer 3D Spheroidal Platform with Transcriptomic Insights. (PubMed, J Med Chem)
    Additionally, suppression of IL-6, TNF-α, and ECM remodeling factors indicated reduced metastatic potential. This strategy highlights NO-mediated synergy as a promising approach to overcome chemoresistance in TNBC.
    Journal
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    TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • VEGFC (Vascular Endothelial Growth Factor C) • MMP9 (Matrix metallopeptidase 9) • CASP10 (Caspase 10)
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    Leukeran (chlorambucil)
    10ms
    Differential expression and hypermethylation of apoptotic genes in circulating nucleic acids are associated with clinical phenotypes of prostate cancer and benign prostatic hyperplasia in Nigerians. (PubMed, Urol Oncol)
    We describe a differential expression of BCL2, BOK, BAD, and MCL1 and methylation of BOK and ESR1 genes in PCa in this study population for the first time. These differentially expressed and methylated genes can be explored for differential diagnosis, monitoring of treatment and new therapeutic targets.
    Journal • IO biomarker
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    ER (Estrogen receptor) • BCL2 (B-cell CLL/lymphoma 2) • MCL1 (Myeloid cell leukemia 1) • CASP7 (Caspase 7) • CASP10 (Caspase 10)
    11ms
    Preliminary study of the mechanism of isolinderalactone inhibiting the malignant behavior of bladder cancer. (PubMed, Curr Urol)
    In vivo, on day 25 of administration, tumor inhibition rates in T24 and EJ-1 tumor-bearing mice were up to 75.24% and 47.43%, respectively, in the ILL high-dose-treated and 71.58% and 43.89%, respectively, in the ILL low-dose-treated groups. Isolinderalactone controls BC progression by inducing apoptosis, suggesting that ILL may be an effective drug for the treatment of BC.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP8 (Caspase 8) • BAK1 (BCL2 Antagonist/Killer 1) • CASP10 (Caspase 10)
    1year
    Comprehensive Pan-cancer Analysis Revealed CASP10 As a Promising Biomarker For Diverse Tumor Types. (PubMed, Int J Immunopathol Pharmacol)
    Finally, WB analysis validated the overexpression of CASP10 in LIHC and STAD tissues. Our comprehensive bioinformatic analysis reveal the function of CASP10 on the diagnosis, prognosis, and progression of diverse cancer types.
    Journal • Pan tumor
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    AFP (Alpha-fetoprotein) • CASP10 (Caspase 10)
    over1year
    Predicting High-Risk Patients with Lung Adenocarcinoma: The Power of Plasma Cell-Related Genes. (PubMed, Oncology)
    Subsequently, we conducted drug sensitivity analysis and immune checkpoint analysis, revealing that the majority of drugs are more sensitive to low-risk patients, while ABT-888, AS601245, and CCT007093 may have greater potential clinical benefits for high-risk patients. Immune checkpoint analysis showed significant differences in the expression of ADORA2A, BTLA, CD276, CD27, CD28, CD40LG, CD48, and TNFRSF14 between high-risk and low-risk patient groups, suggesting their potential as therapeutic targets for LUAD..
    Journal • PARP Biomarker • IO biomarker
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    CD276 (CD276 Molecule) • LY9 (Lymphocyte Antigen 9) • CD28 (CD28 Molecule) • CD27 (CD27 Molecule) • TNFRSF14 (TNF Receptor Superfamily Member 14) • BTLA (B And T Lymphocyte Associated) • ADORA2A (Adenosine A2a Receptor) • CD40LG (CD40 ligand) • CD48 (CD48 Molecule) • CASP10 (Caspase 10) • EPSTI1 (Epithelial Stromal Interaction 1)
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    veliparib (ABT-888)