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8ms
CD33KO-HSPC Infusion Followed by CART-33 Infusion(s) for Refractory/Relapsed AML (clinicaltrials.gov)
P1, N=16, Recruiting, University of Pennsylvania | Not yet recruiting --> Recruiting
Enrollment open • Combination therapy
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CART-33
over1year
New P1 trial • Combination therapy
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CART-33
2years
G-CSF Mobilized Apheresis As an Alternative Source of CAR T-Cells (ASH 2022)
Methods Untransduced T-cells (UTD) and CAR T-cells targeting CD33 (CART33) were manufactured using paired steady state (ss) cells and cells collected after rhG-CSF treatment (mob)...Successful completion of this work may support the use of cryopreserved G-CSF stimulated apheresis units for cell therapy applications. This may allow for an adjunct cell therapy to hematopoietic stem-cell transplant to be manufactured from the same mobilized collection, or provide a means by which previously cryopreserved mobilized units may be utilised, noting frequently lower cumulative chemotherapy exposure in historically cryopreserved T-cells.
CAR T-Cell Therapy
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CD8 (cluster of differentiation 8) • CD33 (CD33 Molecule) • CD34 (CD34 molecule) • IL15 (Interleukin 15) • IL7 (Interleukin 7)
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CD33 expression
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CART-33