CARS2 (Cysteinyl-TRNA Synthetase 2)

Survival analysis showed SARS1 expression was associated with significantly reduced survival across 5 and 10 years, while CARS2 showed significance at 5 years only. These findings support SARS1 as a candidate prognostic biomarker in ILC and suggest broader relevance for ARS genes in breast cancer outcomes.

In light of a comprehensive pan-cancer study, we analyzed these genes to detect the potential clinical value. In conclusion, the constructed LRGS provides important insights for subsequent mechanistic research and can guide clinicians in proposing therapeutic strategies for HNSCC patients.

Furthermore, the potential role of H2S methylation processes mediated by thiol S-methyltransferase (TMT) and thioether S-methyltransferase (TEMT) is outlined in cancer biology, with potential opportunities for targeting them for clinical translation. In order to understand the role of H2S in oncogenesis and tumor progression, one must appreciate the intricate interplay between H2S-synthesizing and H2S-catabolizing enzymes.

P=N/A, N=15, Not yet recruiting, West Virginia University

Collectively, we developed and validated a novel robust nine RBPs for OSCC prognosis prediction. The nine RBPs could serve as an independent and reliable prognostic biomarker and guiding clinical therapy for OSCC patients.

We have developed a novel LRPM that enables risk stratification and identification of poor molecular subtypes in TNBC patients, showing great potential in clinical practice.