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    BIOMARKER:

    CARD11 amplification

    i
    Other names: CARD11, Caspase Recruitment Domain Family Member 11, CARMA1, Caspase Recruitment Domain-Containing Protein 11, Bcl10-Interacting Maguk Protein 3, CARD-Containing MAGUK Protein 1, Carma 1, BIMP3, Caspase Recruitment Domain Family, Member 11, Card-Maguk Protein 1, IMD11A, CARD11, BENTA, IMD11, PPBL
    Entrez ID:
    84433
    Related biomarkers:
    Mutation
    6ms
    Genomic and Transcriptomic Profiles of Blastoid and Pleomorphic Mantle Cell Lymphoma Are Distinct from Classic Histology Mantle Cell Lymphoma (ASH 2023)
    P and B-MCL have the highest degree of aneuploidy and exhibit an immune cold tumor microenvironment. Further studies are ongoing to refine the molecular differences among B and P-MCL compared to C-MCL.
    IO biomarker
    |
    TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • ATM (ATM serine/threonine kinase) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • DNMT3A (DNA methyltransferase 1) • CCND1 (Cyclin D1) • BCL6 (B-cell CLL/lymphoma 6) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • NOTCH2 (Notch 2) • CARD11 (Caspase Recruitment Domain Family Member 11) • MALT1 (MALT1 Paracaspase) • NFKBIE (NFKB Inhibitor Epsilon) • MIR15A (MicroRNA 15a)
    |
    TP53 mutation • ATM mutation • DNMT3A mutation • CDKN2A deletion • SMARCA4 mutation • CARD11 amplification • Chr del(13)(q14) • CCND1 mutation
    8ms
    FISH Panel for Leukemic Cutaneous T-Cell Lymphoma: Extended Patient Cohort Correlation with Blood Involvement and Clinical Outcomes. (PubMed, JID Innov)
    In addition, the previous cost-effective panels were signal transducer and activator of transcription (STAT)3/5B, MYC, TP53, and ARID1A. We now suggest adding RB1 and ZEB1 on the basis of our findings.
    Clinical data • Journal
    |
    TP53 (Tumor protein P53) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • DNMT3A (DNA methyltransferase 1) • RB1 (RB Transcriptional Corepressor 1) • ARID1A (AT-rich interaction domain 1A) • STAT3 (Signal Transducer And Activator Of Transcription 3) • CARD11 (Caspase Recruitment Domain Family Member 11) • CD4 (CD4 Molecule) • ZEB1 (Zinc Finger E-box Binding Homeobox 1)
    |
    CDKN2A deletion • CARD11 amplification