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    GENE:

    CAMKK1 (Calcium/Calmodulin Dependent Protein Kinase Kinase 1)

    i
    Other names: CAMKK1, Calcium/Calmodulin Dependent Protein Kinase Kinase 1, CAMKKA, Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha, Calcium/Calmodulin-Dependent Protein Kinase Kinase 1, Alpha, Calcium/Calmodulin-Dependent Protein Kinase Kinase 1, CaM-Kinase Kinase Alpha, CaM-Kinase IV Kinase, CaM-Kinase Kinase 1, DKFZp761M0423, CaM-KK Alpha, MGC34095, CaM-KK 1, CaMKK 1, CAMKK Alpha Protein, CaMKK Alpha
    Associations

    News

    Trials
    3ms
    HOMER3 drives oral squamous cell carcinoma progression through TRPV6 calcium influx and TUBB3 microtubule stabilization. (PubMed, Oncogene)
    Functional studies reveal that HOMER3 overexpression enhances ECM stiffness, type I collagen deposition, and Aβ accumulation in the tumor stroma, leading to tumor growth and aggressiveness, while HOMER3 knockdown reduces ECM stiffness, disrupts collagen composition, and increases sensitivity to docetaxel. These findings establish HOMER3 as a pivotal regulator of OSCC malignancy and chemoresistance, providing novel insights into its role in orchestrating the tumor microenvironment and identifying it as a promising therapeutic target for OSCC.
    Journal
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    BRAF (B-raf proto-oncogene) • TUBB3 (Tubulin beta 3 class III) • TRPV6 (Transient Receptor Potential Cation Channel Subfamily V Member 6) • CAMKK1 (Calcium/Calmodulin Dependent Protein Kinase Kinase 1)
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    docetaxel
    5ms
    Identification of novel gene fusions in high-grade serous ovarian carcinoma: implications for tumorigenesis and targeted therapy. (PubMed, Cancer Genet)
    This study identified candidate driver fusion genes and suggested new therapeutic targets for HGSOCs.
    Journal
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    ER (Estrogen receptor) • TP53 (Tumor protein P53) • NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3) • AXL (AXL Receptor Tyrosine Kinase) • HDAC1 (Histone Deacetylase 1) • CAMK2D (Calcium/Calmodulin Dependent Protein Kinase II Delta) • LATS1 (Large Tumor Suppressor Kinase 1) • PSMD1 (Proteasome 26S Subunit Non-ATPase 1) • BMPR1A (Bone Morphogenetic Protein Receptor Type 1A) • CAMKK1 (Calcium/Calmodulin Dependent Protein Kinase Kinase 1) • HNRNPUL1 (Heterogeneous Nuclear Ribonucleoprotein U Like 1) • SH3PXD2A (SH3 And PX Domains 2A) • YY1 (YY1 Transcription Factor) • ZNF143 (Zinc Finger Protein 143)
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    TP53 mutation
    12ms
    Orchestrating Intracellular Calcium Signaling Cascades by Phosphosite-Centric Regulatory Network: A Comprehensive Analysis on Kinases CAMKK1 and CAMKK2. (PubMed, OMICS)
    Further, CAMKK2 was identified as a primary orchestrator in mediating intracellular calcium signaling cascades compared to CAMKK1 based on coregulation patterns of phosphosites from proteins involved in the calcium signaling pathway. These molecular details shed promising insights into the pathophysiology of several diseases such as cancers and psychiatric disorders associated with kinase activity dysregulations of CAMKK2 and further open the avenue for novel PTM-directed therapeutic strategies to regulate CAMKK2.
    Journal
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    RPS6KB1 (Ribosomal Protein S6 Kinase B1) • CAMKK1 (Calcium/Calmodulin Dependent Protein Kinase Kinase 1)
    2years
    Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2). (PubMed, J Med Chem)
    We report herein selective, ligand-efficient inhibitors and ligand-directed degraders of CaMKK2 that were used to probe immune and tumor intrinsic biology. These molecules provide two distinct strategies for ablating CaMKK2 signaling in vitro and in vivo.
    Journal
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    CAMKK1 (Calcium/Calmodulin Dependent Protein Kinase Kinase 1)
    over2years
    14-3-3 protein inhibits CaMKK1 by blocking the kinase active site with its last two C-terminal helices. (PubMed, Protein Sci)
    Therefore, Ca /CaM binding suppression and the interaction of the kinase active site of CaMKK1 with the last two C-terminal helices of 14-3-3? protein provide the structural basis for 14-3-3-mediated CaMKK1 inhibition.
    Journal
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    CAMKK1 (Calcium/Calmodulin Dependent Protein Kinase Kinase 1)
    over2years
    Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate liver steatosis by promoting fatty acid oxidation and reducing fatty acid synthesis. (PubMed, JHEP Rep)
    Our study highlights the importance of exosomal CAMKK1 from MSC-ex in mediating lipid metabolism regulation via AMPK-mediated PPARα/CPT-1A and SREBP-1C/fatty acid synthase signalling in hepatocytes. These findings are significant in elucidating novel mechanisms related to MSC-ex-based therapies for preventing NAFLD.
    Journal
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    FASN (Fatty acid synthase) • CAMKK1 (Calcium/Calmodulin Dependent Protein Kinase Kinase 1) • PPARA (Peroxisome Proliferator Activated Receptor Alpha)