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    GENE:

    CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha)

    i
    Other names: CAMK2A, Calcium/Calmodulin Dependent Protein Kinase II Alpha, CaMKIINalpha, KIAA0968, CAMKA, Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Alpha, Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Alpha, Calcium/Calmodulin-Dependent Protein Kinase Type II Alpha Chain, Calcium/Calmodulin-Dependent Protein Kinase II Alpha-B Subunit, CaM Kinase II Alpha Subunit, CaM Kinase II Subunit Alpha, CaM-Kinase II Alpha Chain, CaMK-II Alpha Subunit, CaMK-II Subunit Alpha, CaMKIIalpha, CaMKIIα, CaMKIIα, MRD53, MRT63
    Associations

    News

    Trials
    13d
    Time‑resolved multi-omic analysis of paclitaxel exposure in human iPSC‑derived sensory neurons unveils mechanisms of chemotherapy‑induced peripheral neuropathy. (PubMed, Cell Death Dis)
    In summary, paclitaxel induces transcriptomic and proteomic signatures of the neuronal stress response, neuroinflammation, nociception, and disturbed metabolism. These may explain, in part, the clinical phenotype of sensory loss, hypersensitivity, and neuropathic pain frequently observed in patients suffering from CIPN, but constitute pharmacologically addressable targets.
    Journal
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    CD123 (Interleukin 3 Receptor Subunit Alpha) • BCL2L11 (BCL2 Like 11) • CASP3 (Caspase 3) • CYSLTR2 (Cysteinyl Leukotriene Receptor 2) • IL1R1 (Interleukin 1 receptor, type I) • ARID5A (AT-Rich Interaction Domain 5A) • ATF3 (Activating Transcription Factor 3) • BBC3 (BCL2 Binding Component 3) • CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha) • DUSP1 (Dual Specificity Phosphatase 1) • HMGCS1 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 1) • TNFRSF12A (TNF Receptor Superfamily Member 12A)
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    paclitaxel
    22d
    Bayesian Hyperspherical Graph Mixture-of-Experts Deciphers Cell-Cell Interaction in Spatial Transcriptomics. (PubMed, IEEE Trans Comput Biol Bioinform)
    Together, these results demonstrate that B-HGME offers a powerful tool for spatial systems biology and hypothesis generation in development, immunity, and cancer. The source code of our model is available at https://github.com/zxj8806/B-HGME.
    Journal
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    CALB1 (Calbindin 1) • CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha) • GFAP (Glial Fibrillary Acidic Protein)
    2ms
    A prelimbic molecular clock of protein synthesis for memory persistence. (PubMed, bioRxiv)
    Loss- and gain-of-function approaches demonstrated that eIF2α-regulated, cap-independent translation is essential for recent consolidation and for the enduring stabilization of remote memory, whereas retrieval-induced destabilization engages a mechanistically distinct, eIF4E-dependent translational pathway required for reconsolidation. These findings identify the PL cortex as a dynamic node in which discrete modes of translational control govern the long-term persistence of emotional memories.
    Journal
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    CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha)
    2ms
    Spatially resolved translational dysregulation in Grin2a +/- mouse model of schizophrenia. (PubMed, bioRxiv)
    Non-neuronal cell types including astrocytes, oligodendrocytes, and vascular cells also exhibited region-specific translational changes in neurotransmitter transport, lipid synthesis, myelination, and stress response pathways, some of which co-varied with regional neuron state. Together, our study reveals brain-wide translation dysregulation as a critical mechanism underlying SCZ pathophysiology.
    Preclinical • Journal
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    GRIN2A (Glutamate Ionotropic Receptor NMDA Type Subunit 2A) • CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha) • EGR1 (Early Growth Response 1)
    3ms
    A mitochondria-related gene-based signature predicts pancreatic ductal adenocarcinoma clinical outcome and revealed CAMK2A/THEM4 regulates progression phenotypes and mitophagy in vivo and in vitro. (PubMed, J Transl Med)
    This study establishes a mitochondria-driven prognostic model for PDAC and identifies the CAMK2A-THEM4-AKT axis as a novel therapeutic target. To our knowledge, this is the first pancreatic cancer signature that investigates the synergistic effect of candidate genes, offering both prognostic and mechanistic insights into PDAC progression.
    Clinical data • Preclinical • Journal
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    CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha)
    3ms
    The Proteomic Landscape of CTNNB1 Mutated Low-Grade Early-Stage Endometrial Carcinomas. (PubMed, Cells)
    Intracellular calcium dysfunction was associated with key transcript dysregulation. We found an increased expression of CAMK2A and ROR2, suggesting a potential role for non-canonical Wnt pathway activation in CTNNB1 mutated tumors.
    Journal
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    CD8 (cluster of differentiation 8) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • ROR2 (Receptor Tyrosine Kinase Like Orphan Receptor 2) • CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha)
    4ms
    Identification and experimental verification of necroptosis-related prognostic gene signature and characterization of tumor immune infiltration in lung squamous cell carcinoma. (PubMed, PeerJ)
    A three-gene NRG signature was identified as a prognostic marker in LUSC. These genes appear to influence disease progression and the immune microenvironment, highlighting their potential as therapeutic targets and as a foundation for further investigation.
    Journal • Tumor mutational burden • Gene Signature
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    TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha)
    4ms
    Prediction of Immunotherapy Response and Prognostic Outcomes for Patients With Ovarian Cancer Using PANoptosis-Related Genes. (PubMed, Hum Mutat)
    In vitro, PIK3CG, CAMK2A, NFKB1, PSMA4, and PSMB1 were upregulated in OC cell lines, and knockdown of PIK3CG notably suppressed the proliferative, migratory, and invasive capabilities of OC cells. The PRG model established in this study may contribute to the assessment of immunotherapeutic response and prognosis for OC patients.
    Journal • IO biomarker
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    PIK3CG (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma) • CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha) • STAT4 (Signal Transducer And Activator Of Transcription 4)
    4ms
    Neuroprotection by Resveratrol in Chronic Cerebral Hypoperfusion: A Study on Synaptogenesis Enhancement and Apoptosis Inhibition. (PubMed, Iran J Pharm Res)
    The RSV protects against CCH-induced neuronal damage by inhibiting apoptosis and enhancing synaptic plasticity. These findings highlight RSV's therapeutic potential for vascular cognitive impairment.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • RHOA (Ras homolog family member A) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha) • GRIN2B (Glutamate Ionotropic Receptor NMDA Type Subunit 2B)
    6ms
    Construction and immunohistochemical validation of a necroptosis-related prognostic signature in bladder cancer and its association with tumor immune infiltration. (PubMed, Front Genet)
    Our study delineates a novel five-gene NRG signature with robust prognostic value in BLCA. These gene determinants appear to critically influence both tumor progression and immune microenvironment, thereby representing promising candidates for therapeutic targeting and future mechanistic exploration in bladder cancer biology.
    Journal
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    CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha) • IL33 (Interleukin 33)
    7ms
    Eleganolone, a diterpene isolated from seaweed Bifurcaria bifurcata (Phaeophyceae, Fucales), protects neuronal cells from oxidative stress-induced damage. (PubMed, Eur J Pharmacol)
    Additionally, our data showed that eleganolone downregulated the expression of genes associated with apoptosis (BAX, BNIP3, p53, p38, APAF1), inflammation (NFKB1, TNF-α, IL-6, IL-1β), oxidative stress (HO-1) and neuronal development (CAMK2A, WNT5A, WNT7A) pathways in SH-SY5Y cells exposed to oxidative stressor tert-BOOH. These findings suggest that eleganolone offers neuroprotective potential in ameliorating diverse pathological aspects associated with oxidative stress.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CASP3 (Caspase 3) • CASP7 (Caspase 7) • IL1B (Interleukin 1, beta) • WNT7A (Wnt Family Member 7A) • APAF1 (Apoptotic peptidase activating factor 1) • CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha)
    11ms
    Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice. (PubMed, Nat Commun)
    Single nucleus transcriptomics indicated that CD primarily affected oligodendrocytes, significantly restored myelin gene expression, increased density of myelinated axons, inhibited the disease-associated oligodendrocyte response, and downregulated the lipid-associated genes Plin4 and ApoD. These results suggest that reducing excess free cholesterol in the CNS could be a viable ALS treatment strategy.
    Preclinical • Journal
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    CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha) • NEFL (Neurofilament Light Chain)