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    BIOMARKER:

    CALR elevation

    i
    Other names: CALR, Calreticulin, Sicca Syndrome Antigen A (Autoantigen Ro; Calreticulin), Endoplasmic Reticulum Resident Protein 60, Calregulin, CC1qR, CRP55, ERp60, HACBP, Grp60, CRT, SSA, RO, Epididymis Secretory Sperm Binding Protein Li 99n, Autoantigen Ro, HEL-S-99n, FLJ26680, CRTC
    Entrez ID:
    811
    Related biomarkers:
    Mutation
    Others
    Associations

    News

    Trials
    over1year
    Caspase-8 contributes to an immuno-hot microenvironment by promoting phagocytosis via an ecto-calreticulin-dependent mechanism. (PubMed, Exp Hematol Oncol)
    Our data revealed a causative role of Casp8 in modulating the immunogenicity of tumor cells and responsiveness to ICB immunotherapies and proposed radiotherapy as a salvage approach to overcome Casp8 deficiency-mediated ICB resistance.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • CASP8 (Caspase 8) • CALR (Calreticulin)
    |
    CALR elevation