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    BIOMARKER:

    CALR elevation

    i
    Other names: CALR, Calreticulin, Sicca Syndrome Antigen A (Autoantigen Ro; Calreticulin), Endoplasmic Reticulum Resident Protein 60, Calregulin, CC1qR, CRP55, ERp60, HACBP, Grp60, CRT, SSA, RO, Epididymis Secretory Sperm Binding Protein Li 99n, Autoantigen Ro, HEL-S-99n, FLJ26680, CRTC
    Entrez ID:
    811
    Related biomarkers:
    Mutation
    Others
    Associations

    News

    Trials
    5d
    Calreticulin-driven autophagy enhances cell proliferation in laryngeal squamous cell carcinoma. (PubMed, Tissue Cell)
    Our study identifies CALR as an oncogene in LSCC, where it promotes tumor progression by inducing autophagy and inhibiting apoptosis. Targeting CALR or modulating autophagy may represent novel therapeutic strategies for LSCC.
    Journal
    |
    CALR (Calreticulin)
    |
    CALR elevation
    almost2years
    Caspase-8 contributes to an immuno-hot microenvironment by promoting phagocytosis via an ecto-calreticulin-dependent mechanism. (PubMed, Exp Hematol Oncol)
    Our data revealed a causative role of Casp8 in modulating the immunogenicity of tumor cells and responsiveness to ICB immunotherapies and proposed radiotherapy as a salvage approach to overcome Casp8 deficiency-mediated ICB resistance.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • CASP8 (Caspase 8) • CALR (Calreticulin)
    |
    CALR elevation