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    DRUG:

    calcitriol (BPM 31543)

    i
    Other names: Topical 31543, BPM 31543, API-31543, compound 31543 calcitriol
    Associations

    News

    Trials
    Company:
    BPGbio
    Drug class:
    Calcitriol receptor agonist
    Related drugs:
    Associations

    News

    Trials
    over6years
    A Feasibility Study of Biologically Focused Therapy for Myelodysplastic Syndrome Patients Refractory to Hypomethylating Agents (ASH 2019)
    MTB recommendations varied widely among patients and encompassed various drug classes including targeted therapies (venetoclax, sorafenib, lenalidomide, ruxolitinib, midostaurin, everolimus), cytotoxic agents (cytarabine, fludarabine), differentiative agents (calcitriol, ATRA), HMAs, and androgens (danazol) as single agents or in combination...Personalized treatment recommendations accurately predicted clinical responses in vivo and enabled some patients to be bridged to allogeneic HCT. Randomized prospective trials are needed to determine whether this approach may improve outcomes for patients with HMA-refractory MDS.
    Clinical
    |
    DNMT3A (DNA methyltransferase 1) • SRSF2 (Serine and arginine rich splicing factor 2)
    |
    Venclexta (venetoclax) • sorafenib • everolimus • lenalidomide • cytarabine • Jakafi (ruxolitinib) • midostaurin • fludarabine IV • calcitriol (BPM 31543)