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    GENE:

    CALB2 (Calbindin 2)

    i
    Other names: CALB2, Calbindin 2, Calretinin, CAL2, 29 KDa Calbindin, CAB29, CR, Testicular Secretory Protein Li 8, Calbindin 2, 29kDa (Calretinin), Calbindin 2, (29kD, Calretinin), Calbindin D29K
    Associations

    News

    Trials
    2ms
    Neurotransmitter receptor-associated gene signature: prognostic and immunosuppressive microenvironment in NSCLC. (PubMed, Future Sci OA)
    Expression analysis indicated that CPS1 and CALB2 were downregulated in NSCLC samples, whereas CDH17, NIPAL4, SOX2, and KREMEN2 were upregulated. The genes CPS1, CDH17, NIPAL4, SOX2, CALB2, and KREMEN2 were identified as prognostic biomarkers in NSCLC, providing insights into their potential roles in disease progression and therapeutic targeting.
    Journal • Gene Signature
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    SOX2 • CPS1 (Carbamoyl-Phosphate Synthase 1) • CALB2 (Calbindin 2) • CDH17 (Cadherin 17)
    2ms
    Cellular reprogramming of H3K27M pediatric high-grade glioma to neuron-like state. (PubMed, Acta Neuropathol Commun)
    These findings advance the concept of 'differentiation therapy' as a promising intervention to reduce phenotypic plasticity and malignancy in pHGG ecosystems. While these are early in vitro findings, the potential ability to steer and control glioma cells toward stable, less malignant fates offers promising translational potential for patient-centered targeted therapies.
    Journal
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    ERBB4 (erb-b2 receptor tyrosine kinase 4) • BCL11B (BAF Chromatin Remodeling Complex Subunit BCL11B) • WNT7A (Wnt Family Member 7A) • CALB2 (Calbindin 2) • SLC1A2 (Solute Carrier Family 1 Member 2)
    4ms
    CALB2 Overexpression Attenuates Neuropathic Pain by Inhibiting Oxidative Stress and Modulating Microglia M1/M2 Polarization Through Activation of the cAMP/CREB Pathway. (PubMed, Neurochem Res)
    Mechanistically, CALB2 overexpression inhibited NP development by activating the cyclic adenosine monophosphate/cAMP response element-binding protein (cAMP/CREB) signaling pathway. CALB2 overexpression inhibits oxidative stress and promotes microglia transition from M1 to M2 phenotype by activating the cAMP/CREB pathway, which in turn attenuates NP.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10) • CALB1 (Calbindin 1) • ARG1 (Arginase 1) • IL1B (Interleukin 1, beta) • CALB2 (Calbindin 2)
    9ms
    CALB2 facilitates macrophage M2 polarization to promote the growth and metastasis of pancreatic adenocarcinoma. (PubMed, Cell Signal)
    WTAP knockdown restrained the growth and metastasis of PAAD in nude mice via the FOSL1/CALB2 axis. In conclusion, WTAP increased the m6A level of FOSL1, activated CALB2 transcription, and promoted M2 polarization of macrophages, thereby promoting the growth and metastasis of PAAD.
    Journal
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    FOSL1 (FOS Like 1) • GLI2 (GLI Family Zinc Finger 2) • CALB2 (Calbindin 2) • WTAP (WT1 Associated Protein)
    11ms
    Cytoplasmic HuR Expression Enhances Chemoresistance in Pleural Mesothelioma Through Increased Expression of CALB2, Promotion of the E2F Pathway, and Suppression of the p53 Pathway. (PubMed, Thorac Cancer)
    Cytoplasmic HuR expression increases the chemoresistance and postoperative recurrence risk of pleural mesothelioma, making it a potential biomarker for predicting therapeutic prognosis. However, the mechanism of HuR transfer to the cytoplasm remains unclear for therapeutic application.
    Retrospective data • Journal
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    CALB2 (Calbindin 2)
    1year
    Identification of a metabolic-immune signature associated with prognosis in colon cancer and exploration of potential predictive efficacy of immunotherapy response. (PubMed, Clin Exp Med)
    This subset of patients may potentially respond well to immune checkpoint inhibitor therapy. MIRPS may be used as a novel prognostic tool for CC and have potential value for immunotherapy response prediction.
    Journal • Tumor mutational burden • IO biomarker
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    TMB (Tumor Mutational Burden) • CD36 (thrombospondin receptor) • MEN1 (Menin 1) • STC2 (Stanniocalcin 2) • CALB2 (Calbindin 2) • CLDN2 (Claudin 2)
    1year
    Phosphatidylinositol promoted the proliferation and invasion of pituitary adenoma cells by regulating POU1F1 expression. (PubMed, Cancer Metab)
    In addition, PI propelled the metastasis of GH3 cells in vivo, and elevated the expression of PITPNM1, POU1F1, C2orf15 and LDHA. These results suggested that elevated serum PI might contribute to the proliferation and invasion of pituitary adenoma by regulating the expression of PITPNM1/AKT/ERK/POU1F1 axis.
    Journal
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    LDHA (Lactate dehydrogenase A) • CALB2 (Calbindin 2) • GLUD2 (Glutamate Dehydrogenase 2) • SLC4A1 (Solute Carrier Family 4 Member 1)
    1year
    Comprehensive analysis identifies a lactylation-related signature for predicting prognosis and guiding therapies in colon adenocarcinoma. (PubMed, Gene)
    This comprehensive analysis identified a lactylation-related signature with significant prognostic and therapeutic implications for COAD. The findings highlight the importance of lactylation in COAD biology and offer novel insights for developing personalized treatment strategies, potentially improving patient outcomes in this prevalent malignancy.
    Journal
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    CALB2 (Calbindin 2) • FABP4 (Fatty Acid Binding Protein 4)
    over1year
    Genomic landscape of superficial malignant peripheral nerve sheath tumor. (PubMed, Lab Invest)
    Next-generation sequencing revealed multiple differential features between SF- MPNST, D-MPNST, SCM, and DM, including tumor mutation burden, mutational signatures, and differentially expressed genes. These findings help advance our understanding of disease pathogenesis and improve diagnostic modalities.
    Journal • Tumor mutational burden
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    TMB (Tumor Mutational Burden) • PRAME (Preferentially Expressed Antigen In Melanoma) • MLPH (Melanophilin) • SOX11 (SRY-Box Transcription Factor 11) • CALB2 (Calbindin 2) • SOX8 (SRY-Box Transcription Factor 8)
    over1year
    COADREADx: A comprehensive algorithmic dissection of colorectal cancer unravels salient biomarkers and actionable insights into its discrete progression. (PubMed, PeerJ)
    COADREADx provides uncertainty measures for its predictions and needs clinical validation. It has been deployed for experimental non-commercial use at: https://apalanialab.shinyapps.io/coadreadx/.
    Journal
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    DKK1 (dickkopf WNT signaling pathway inhibitor 1) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • HOTAIR (HOX Transcript Antisense RNA) • CDH3 (Cadherin 3) • TINCR (TINCR Ubiquitin Domain Containing) • CALB2 (Calbindin 2) • HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) • IGFBP1 (Insulin Like Growth Factor Binding Protein 1) • ESM1 (Endothelial Cell Specific Molecule 1)
    over1year
    FGF2 promotes the expansion of parietal mesothelial progenitor pools and inhibits BMP4-mediated smooth muscle cell differentiation. (PubMed, Front Cell Dev Biol)
    A Wnt activator, CHIR99021, was pivotal in MPC maturation to CALB2+ mesothelial cells, while BMP4 or FGF2 was limited. Our results demonstrated central pathways critical for mesothelial cell behaviors.
    Journal
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    FGF2 (Fibroblast Growth Factor 2) • CALB2 (Calbindin 2) • BMP4 (Bone Morphogenetic Protein 4)
    over1year
    CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment. (PubMed, J Exp Clin Cancer Res)
    These findings identify CALB2 as a key regulator of inflammatory reprogramming to promote PDAC metastatic progression. Combination therapy with αCXCL14 monoclonal antibody and gemcitabine emerges as a promising strategy to suppress distant metastasis and improve survival outcomes in PDAC with CALB2 overexpression.
    Journal
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    IL6 (Interleukin 6) • CALB2 (Calbindin 2) • CXCL14 (C-X-C Motif Chemokine Ligand 14)
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    IL6 expression
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    gemcitabine