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GENE:

CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A)

News alerts, weekly reports and conference planners

24d

Bile duct tumor thrombus (intraductal polypoid growth)-positive intrahepatic cholangiocarcinoma: clinicopathologic and genomic analysis. (PubMed, J Pathol)

These results highlight the importance of evaluating BDTT in SDT, as it may be the main route of hilar extension in aggressive cases.

24 days ago

Journal

KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • NRAS (Neuroblastoma RAS viral oncogene homolog) • FGFR2 (Fibroblast growth factor receptor 2) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • ARID1A (AT-rich interaction domain 1A) • NF1 (Neurofibromin 1) • BAP1 (BRCA1 Associated Protein 1) • KMT2D (Lysine Methyltransferase 2D) • MUC1 (Mucin 1) • SMAD4 (SMAD family member 4) • MLL2 (Myeloid/lymphoid or mixed-lineage leukemia 2) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • MUC4 (Mucin 4, Cell Surface Associated) • CDX2 (Caudal Type Homeobox 2) • MUC2 (Mucin 2) • RSPO3 (R-Spondin 3) • CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A) • MUC17 (Mucin 17) • MUC5AC (Mucin 5AC) • MUC6 (Mucin 6) • PTPRK (Protein Tyrosine Phosphatase Receptor Type K) • TGFBR1 (Transforming Growth Factor Beta Receptor 1)

FGFR2 mutation • FGFR2 fusion • FGFR2 rearrangement

25d

Non-Huntington's disease chorea: an expanding universe with acquired causes. (PubMed, Brain)

In addition, it has been established that a growing list of acquired causes may also mimic HD, including autoimmune illnesses such as primary antiphospholipid syndrome, paraneoplastic chorea, and anti-IGLON5. Here we aim to review the epidemiology, aetiology, clinical and laboratory findings of the wide range of conditions associated with HD phenocopies, and proceed to suggest a practical diagnostic approach to the investigation of HD phenocopies taking into account the age at onset, ethnicity, and geographic location of individuals.

25 days ago

Journal

PPP2R2B (Protein Phosphatase 2 Regulatory Subunit Bbeta) • ATXN3 (Ataxin 3) • CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A)

Brexpiprazole induces acute cardiotoxicity via disrupting calcineurin/NFAT and calcium signaling pathway: A validation from biochemical, echocardiographic, histological, and computational analysis. (PubMed, Tissue Cell)

In silico analyses supported these results showing binding affinity of BPZ with important key regulatory proteins. Collectively, the obtained data suggest that long-term exposure to BPZ results in cardiotoxicity mediated by oxidative stress, inflammation, apoptosis, and functional cardiac dysfunction.

1 month ago

Journal • IO biomarker

HMOX1 (Heme Oxygenase 1) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CASP9 (Caspase 9) • NFATC1 (Nuclear Factor Of Activated T Cells 1) • PPP3CA (Protein Phosphatase 3 Catalytic Subunit Alpha) • CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A) • CAT (Catalase) • CRP (C-reactive protein) • NFATC3 (Nuclear Factor Of Activated T Cells 3)

3ms

M6A modification mediates CACNA1A stability to drive the progression of ovarian cancer by inhibiting ferroptosis. (PubMed, J Ovarian Res)

Overall, this study elucidates that super enhancer-driven IGF2BP3 targets CACNA1A via m6A modification, in turn which inhibits ferroptosis in ovarian cancer. It highlights that targeting the IGF2BP3-CACNA1A regulatory axis could be an effective strategy impeding ovarian cancer progression.

3 months ago

Journal

CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A) • IGF2BP3 (Insulin Like Growth Factor 2 MRNA Binding Protein 3) • TFAP2A (Transcription Factor AP-2 Alpha)

11ms

Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups. (PubMed, Cancer Cell)

Drug screening using patient-derived tumor organoids identifies cyclin-dependent kinase (CDK) 5 and Calcium Voltage-Gated Channel Subunit Alpha1 D (CACNA1D) as ubiquitous and subtype-specific targets, respectively, with in vivo validation using xenograft models. Together, our proteogenomic analyses illustrate a comprehensive molecular landscape of NF-PanNETs, revealing biological insights and therapeutic vulnerabilities.

11 months ago

Journal

CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A)

1year

The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer. (PubMed, Open Med (Wars))

Oxaliplatin (OXA) is among the most common chemotherapy drugs and is the base component of the FOLFOX regimen (OXA + leucovorin + 5-fluorouracil) and CapeOX regimen (OXA + capecitabine). This study presents novel data on first-line antihypertensive NTD, exerting inhibitory effects on cell proliferation and migration in CRC and revealing synergistic activity with OXA by downregulating CACNA1D. NTD may be a candidate as a promising chemosensitizer as an OXA new combination to improve the efficacy and safety of CRC therapy.

1 year ago

Journal

CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A)

5-fluorouracil • capecitabine • oxaliplatin • leucovorin calcium

over1year

The L-type calcium channel CaV1.3: A potential target for cancer therapy. (PubMed, J Cell Mol Med)

The development of selective blockers of the CaV1.3 channel has been of great interest and is expected to be a new option for the treatment of cancers such as prostate cancer and endometrial cancer. We present the pharmacological properties of CaV1.3 and the current status of selective blocker development, and analyse the challenges and possible directions for breakthroughs in the development of tailored medicines.

over 1 year ago

Review • Journal

CAV1 (Caveolin 1) • CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A)

over1year

CDHu40: a novel marker gene set of neuroendocrine prostate cancer. (PubMed, Brief Bioinform)

Importantly, elevated CDHu40 scores derived from our predictive model showed a robust correlation with unfavorable survival outcomes in patients, indicating the potential of the CDHu40 score as a promising indicator for predicting the survival prognosis of those patients with the NE phenotype. Motif enrichment analysis on the top candidates suggests that REST and E2F6 may serve as key regulators in the NEPC progression.

over 1 year ago

Journal

FOLH1 (Folate hydrolase 1) • CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A)

over1year

A Bruton tyrosine kinase inhibitor-resistance gene signature predicts prognosis and identifies TRIP13 as a potential therapeutic target in diffuse large B-cell lymphoma. (PubMed, Sci Rep)

Bruton tyrosine kinase inhibitor (BTKi) combined with rituximab-based chemotherapy benefits diffuse large B-cell lymphoma (DLBCL) patients...TRIP13 was found to be overexpressed in DLBCL and BTKi-resistant DLBCL cell lines, knocking down TRIP13 suppresses cell proliferation, promotes cell apoptosis, and enhances the apoptosis effect of BTKi on DLBCL cells by regulating the Wnt/β-catenin pathway. In conclusion, our study presents a novel BRRGs signature that could serve as a promising prognostic marker in DLBCL, and TRIP13 might be a potential therapeutic target for resistant DLBCL.

over 1 year ago

Journal • Gene Signature

TRIP13 (Thyroid Hormone Receptor Interactor 13) • CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A)

Rituxan (rituximab)

over1year

Discovery of genomic and transcriptomic pleiotropy between kidney function and soluble receptor for advanced glycation end products using correlated meta-analyses: The Long Life Family Study. (PubMed, Aging Cell)

Integrating genomic annotation and transcriptional gene activity revealed the enrichment of genetic elements in kidney function and aging-related processes. The identified pleiotropic loci and gene expressions for eGFR and sRAGE suggest their underlying shared genetic effects and highlight their roles in kidney- and aging-related signaling pathways.

over 1 year ago

Journal • Metastases

KCNQ1OT1 (KCNQ1 Opposite Strand/Antisense Transcript 1) • MIR23A (MicroRNA 23a) • CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A)

over1year

Screening of co-expressed genes in hypopharyngeal carcinoma with esophageal carcinoma based on RNA sequencing and Clinical Research. (PubMed, Sci Rep)

GABRG2, CNTNAP2, and SCN4B in the hub genes have high diagnostic value in determining whether hypopharyngeal carcinoma patients have combined esophageal carcinoma (AUC: 0.944, 0.944, 0.972). These genes could possibly be used as potential molecular markers for assessing the risk of co-morbidity of hypopharyngeal carcinoma combined with esophageal carcinoma.

over 1 year ago

Journal

CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A)

2years

Whole-exome sequencing of Nigerian benign prostatic hyperplasia reveals increased alterations in apoptotic pathways. (PubMed, Prostate)

NGRn BPH contained significant germline alteration interactions (BRCA2_rs11571831 and TP53_rs1042522) and increased somatic alteration frequencies (LMTK2, LRP1, COL18A1, CABP1, and FKBP1C) that impact apoptosis. Normal prostate development is maintained by balancing apoptotic and proliferative activity. Dysfunction in either mechanism can lead to abnormal prostate growth. This work is the first to examine genomic sequencing in NGRn BPH and provides data that fill known gaps in the understanding BPH and how it impacts men of African ancestry.

2 years ago

Journal • BRCA Biomarker

TP53 (Tumor protein P53) • BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • LRP1B (LDL Receptor Related Protein 1B) • PMS2 (PMS1 protein homolog 2) • BARD1 (BRCA1 Associated RING Domain 1) • HSD3B1 (Hydroxy-Delta-5-Steroid Dehydrogenase 3 Beta- And Steroid Delta-Isomerase 1) • LRP1 (LDL Receptor Related Protein 1) • PKD1 (Polycystin 1) • CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A) • DNAH9 (Dynein Axonemal Heavy Chain 9) • LMTK2 (Lemur Tyrosine Kinase 2) • PKHD1 (PKHD1 Ciliary IPT Domain Containing Fibrocystin/Polyductin) • PRKD1 (Protein Kinase D1)