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BIOMARKER:

BTN2A1-H

i
Other names: BTN2A1, Butyrophilin Subfamily 2 Member A1, BT2.1, BTF1, Butyrophilin Subfamily 2 Member A1, BK14H9.1, DJ3E1.1, BTN2.1
Entrez ID:
almost3years
Soluble BTN2A1 Is a Potential Prognosis Biomarker in Pre-Treated Advanced Renal Cell Carcinoma. (PubMed, Front Immunol)
Our results suggest that the baseline level of plasmatic BTN2A1 could be an independent prognosis factor of PFS after nivolumab for pre-treated patient with mRCC. However, these results need to be validated in a larger prospective cohort and the biological role of BTN subfamily and γδ T cell immunity in mRCC must be elucidated.
Journal • PD(L)-1 Biomarker • IO biomarker
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PD-L1 (Programmed death ligand 1) • PD-1 (Programmed cell death 1) • BTLA (B And T Lymphocyte Associated) • BTN2A1 (Butyrophilin Subfamily 2 Member A1) • BTN3A1 (Butyrophilin Subfamily 3 Member A1)
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BTN2A1-H
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Opdivo (nivolumab)
almost4years
[VIRTUAL] Soluble BTN2A1 as a potential predictive biomarker of immune checkpoint inhibitor efficacy in advanced non-small cell lung cancer (NSCLC). (ASCO 2020)
The confirmation cohort (Paoli-Calmettes Institute) included 42 patients treated with ICI (nivolumab or pembrolizumab) in a longitudinal prospective setting (Immunosup trial, NCT03595813). In advanced NSCLC patients, a high baseline plasmatic concentration of soluble BTN2A1 was correlated with improved outcomes for ICI, but not for chemotherapy, suggesting that baseline soluble BTN2A1 level is a potential predictive biomarker of ICI efficacy. Additional studies are ongoing to confirm this finding. Research Funding: Institut Paoli Calmettes and Rennes University Hospital
Clinical • Checkpoint inhibition • PD(L)-1 Biomarker • IO biomarker
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PD-L1 (Programmed death ligand 1) • PD-1 (Programmed cell death 1) • BTN2A1 (Butyrophilin Subfamily 2 Member A1)
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BTN2A1-H
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Keytruda (pembrolizumab) • Opdivo (nivolumab)