BSG (Basigin (Ok Blood Group))

While it is known that Warburg effects in cancers increased lactate production, followed by selection of higher MCT1 expression which enhanced cancer cell survival by exporting lactate, our findings reveal a new opportunity for killing cancer cells by increased 18β-GA sensitivities of cancer cells with higher MCT1 expression due to the Warburg effect. Thus, our results have revealed a biomarker for 18β-GA sensitivity and suggested the possibility of using Warburg effect to allow drug entry into tumor cells, and will stimulate further molecular mechanistic studies and improvements of traditional Chinese herb medicines.

Sting activation was visualized longitudinally using 3'-deoxy-3'-[18F]-fluorothymidine ([18F]-FLT) PET, which peaked 72-96 hours after 8803 administration. In summary, 8803 combined with RT triggers distinctive antiglioma immune reactivity, facilitates BBB opening, and warrants consideration for up-front clinical trials in glioblastoma, where treatment effects can be monitored using [18F]-FLT PET imaging.

Pharmacological inhibition with dasatinib attenuated CD147-driven overactivation and exhaustion. Furthermore, embedding the CD147 intracellular domain into CAR-T constructs significantly enhanced their cytotoxic efficacy while reducing exhaustion. These findings advance our understanding of T cell exhaustion in tumors and may inform strategies to optimize CAR-T therapy.

Multivariate ROC curves revealed a diagnostic signature (MM panel) with a sensitivity 86.4% and specificity 91.6%, and a predictive signature (Response panel) with a sensitivity 80% and specificity 91.2%. In conclusion we identified two EV signatures that may have potential as a non-invasive liquid biopsy to complement or replace invasive BM sampling for monitoring patient response to DARA.

Moreover, CD147 can increase the sensitivity of FIT for detecting either AA or CRC by combinatory use. However, false positivity is the concern of CD147, which should be further resolved in the future.

Conclusions This study establishes BSG/CD147 upregulation as an early molecular event in hepatocarcinogenesis that integrates hepatocyte dedifferentiation, microenvironmental signaling, and tumor progression. Strong and specific expression in small lesions < 2 cm underscores potential as a precision biomarker and imaging target for early HCC detection, risk stratification, and therapeutic development.

More importantly, PDC1 demonstrated promising targeting selectivity and improved the tumor-inhibition efficiency in ovarian cancer-xenograft mouse models without systemic toxicity. This multiple protease-activated, disulfide-bridging PDC strategy provides a novel, precise and safe ADC-targeted therapeutics against ovarian cancer.

P1, N=4, Not yet recruiting, Mianyang Central Hospital; Mianyang Central Hospital

Here, we discuss molecular mechanisms and physiological contexts of asymmetric secondary active transmembrane transport. Focus is laid on experimentally established cases, and examples are given in which putative bias in transport directionality may have been overlooked.

Using the THPP/PEI assemblies, we demonstrated that the expression level of CD147 of EVs derived from the urine samples of colon cancer patients was 4.3-fold higher than that from the urine samples of healthy donors with a p-value less than 0.01. It is expected that the new THPP/PEI assemblies in this work has potential to be applied to liquid biopsy technology because of their portability and cost effectiveness.

These interactions contribute to metabolic reprogramming across glucose, lipid, amino acid, and mitochondrial pathways, thereby linking CD147-mediated metabolic plasticity to tumor dissemination and metastasis. By integrating insights into immune and stromal modulation within the tumor microenvironment (TME), this review highlights the multifaceted roles of CD147 and its glycoprotein interactome in shaping the metastatic niche.

We conclude that EMMPRIN is a gatekeeper that prevents cells from entering dormancy, and that hMR18-mAb disrupts this effect. As it is the first antibody shown to induce dormancy in tumor cells and stop the development of metastases, this could become a new therapeutic strategy to prevent and treat metastasis.