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Bria-OTS
i
Other names: Bria-OTS, Bria-BRES
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Company:
BriaCell
Drug class:
Immunostimulant, T-cell stimulant
Related drugs:
5ms
A Study of BRIA-OTS Cellular Immunotherapy in Metastatic Recurrent Breast Cancer (clinicaltrials.gov)
P1/2, N=18, Recruiting, BriaCell Therapeutics Corporation
New P1/2 trial • IO biomarker • Metastases
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PD-L1 (Programmed death ligand 1) • PD-L2 (Programmed Cell Death 1 Ligand 2) • PRAME (Preferentially Expressed Antigen In Melanoma)
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Tevimbra (tislelizumab-jsgr) • cyclophosphamide • Bria-OTS
over1year
Engineering semi-allogeneic whole cancer vaccines with enhanced immunogenicity for the treatment of advanced solid tumors (AACR 2023)
We sought to harness gene-modified tumor cells as a vaccine platform and developed cancer vaccines composed of breast cancer cells expressing GM-CSF (SV-BR-1-GM). Different types of cancer vaccines have been developed with moderate success, often hampered by lack of strong immunogenicity and complex manufacturing. BriaCell’s Bria OTS provides a solution by increasing vaccine immunogenicity and decreasing manufacturing costs while personalizing the therapy based on matching the patient’s HLA type.1.Lacher MD et al, Front Immunol. 2018 May 15;9:776
Metastases
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CD4 (CD4 Molecule) • CSF2 (Colony stimulating factor 2) • IFNA1 (Interferon Alpha 1) • IL7 (Interleukin 7) • CD80 (CD80 Molecule) • CD86 (CD86 Molecule)
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CSF2 expression
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Bria-IMT (SV-BR-1-GM) • Bria-OTS
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