Breast Cancer

P=N/A, N=100, Recruiting, University of California, San Francisco | Not yet recruiting --> Recruiting

P=N/A, N=866, Active, not recruiting, Spanish Breast Cancer Research Group | Recruiting --> Active, not recruiting

P=N/A, N=145, Active, not recruiting, Intuitive Surgical | Recruiting --> Active, not recruiting

P3, N=1600, Completed, Trans Tasman Radiation Oncology Group Ltd | Active, not recruiting --> Completed

P2, N=42, Not yet recruiting, Fudan University

miR-542-3p upregulation or TMBIM6 downregulation counter-balanced the pro-tumor effects of hsa_circ_0000520 overexpression. hsa_circ_0000520 promotes BC proliferation and metastasis through miR-542-3p-targeted TMBIM6.

This noncanonical function of EZH2, which operates independently of its methyltransferase activity, is linked to enhanced tumor cell proliferation and inhibition of apoptosis. Our findings reveal that EZH2 functions in a chromatin context-dependent manner by cooperating with E2F1 in TNBC, highlighting that the EZH2-E2F1 interaction, independent of PRC2, plays a key role in remodeling chromatin structure and facilitating TNBC proliferation.

Our work establishes ALDH3A2 as a pivotal regulator of lipid metabolic reprogramming in TNBC metastasis, providing mechanistic insights into AA-mediated tumor progression. These findings position ALDH3A2 as a promising therapeutic target and prognostic biomarker for TNBC management.

Moreover, lactate is taken up and oxidized in mitochondria by the CD147/MCT1/LDHB complex, which correlates with stemness potentials and tumor metastasis in patients with breast cancer. An intracellularly expressed single-chain variable fragment targeting mitochondrial CD147 (mito-CD147 scFv) effectively disrupts the mitochondrial CD147/MCT1/LDHB complex, inhibits lactate-induced stemness potential, depletes circulating breast cancer cells, and reduces metastatic burden, suggesting promising clinical applications in reducing lactate-fueled metastasis.

Breast cancer survivors enrolled in several forms of exercise training showed improved cytokine parameters compared with counterparts who did not perform exercise. The benefits of exercise training on cytokine profiles of breast cancer survivors were evident with both aerobic and resistance training, whether performed separately or in combination, and with other training regimens such as tai chi and yoga.

The newly developed aptasensor demonstrated high sensitivity and good reproducibility for HER2 detection. The aptasensor showed a wide linear range of 0.001-100 ng mL-1, a very low limit of detection (LOD) of 0.30 pg mL-1, and a limit of quantification (LOQ) of 1.0 pg mL-1, indicating its significant potential for clinical diagnostic applications.

The effect in Orai expression mediated by activation of Notch1 signaling pathway was mimicked by the expression of HEY1 or the non-phosphorylatable HEY1-S68A mutant; by contrast, expression of the phosphomimetic HEY1-S68D mutant was without effect on Orai expression. Understanding the Notch1-HEY1-Orai axis might provide insights into the development of subtype-specific therapeutic strategies targeting breast cancer.