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    GENE:

    BRD3OS (BRD3 Opposite Strand)

    i
    Other names: BRD3OS, BRD3 Opposite Strand, Long Intergenic Non-Protein Coding RNA 94, NCRNA00094, LINC00094, Putative Uncharacterized Protein BRD3OS, BRD3 Opposite Strand Protein, Non-Protein Coding RNA 94, BA374P20.3, FLJ35348, LP2477
    Associations

    News

    Trials
    over3years
    Super Enhancer-Regulated LINC00094 (SERLOC) Upregulates the Expression of MMP-1 and MMP-13 and Promotes Invasion of Cutaneous Squamous Cell Carcinoma. (PubMed, Cancers (Basel))
    Elevated BRD3OS (LINC00094) expression was detected in cSCC cells, and expression was downregulated by SE inhibitors THZ1 and JQ1 and via the MEK1/ERK1/2 pathway...Based on these observations, BRD3OS (LINC00094) was named SERLOC (super enhancer and ERK1/2-Regulated Long Intergenic non-protein coding transcript Overexpressed in Carcinomas). These results reveal the role of SERLOC in cSCC invasion and identify it as a potential therapeutic target in advanced cSCC.
    Journal
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    MAP2K1 (Mitogen-activated protein kinase kinase 1) • MMP1 (Matrix metallopeptidase 1) • BRD3 (Bromodomain Containing 3) • BRD3OS (BRD3 Opposite Strand)
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    JQ-1