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    BIOMARKER:

    BRAF V600E + PTEN deletion

    i
    Other names: PTEN, Phosphatase and tensin homolog, Mutated In Multiple Advanced Cancers 1, Phosphatase And Tensin Homolog, Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, MMAC1, TEP1, MMAC1 Phosphatase And Tensin Homolog Deleted On Chromosome 10, Mitochondrial Phosphatase And Tensin Protein Alpha, Phosphatase And Tensin-Like Protein, Protein Tyrosine Phosphatase, Mitochondrial PTENalpha, PTENbeta, PTEN1, CWS1, GLM2, MHAM, BRAF, B-raf proto-oncogene, B-raf
    Entrez ID:
    673; 5728
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over1year
    Dual targeting of melanoma translation by MNK/eIF4E and PI3K/mTOR inhibitors. (PubMed, Cell Signal)
    We used a highly specific PI3K/mTOR inhibitor, dactolisib (NVP-BEZ235), and Mnk inhibitor - CGP57380 alone and in combination...Although when used independently, both drugs suppressed cell proliferation and migration, their combination has additional antitumor effects. We demonstrate that simultaneous inhibition of both pathways may prevent possible drug resistance.
    Journal
    |
    PTEN (Phosphatase and tensin homolog)
    |
    BRAF V600E • BRAF V600 • BRAF V600E + PTEN deletion
    |
    dactolisib (RTB101)