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    BIOMARKER:

    BRAF mutation + TP53 mutation

    i
    Other names: BRAF, B-raf proto-oncogene, B-raf proto-oncogene, Serine/threonine kinase, V-Raf murine sarcoma viral oncogene homolog B, Serine/threonine-protein kinase B-Raf, Proto-oncogene B-Raf, BRAF1, RAFB1, B-raf proto-oncogene Serine/threonine-protein kinase, Murine sarcoma viral (V-Raf) oncogene homolog B1, B-raf serine/threonine-protein, 94 KDa B-raf protein, B-RAF1, TP53, Tumor Protein P53, Cellular Tumor Antigen P53, Phosphoprotein P53, Tumor Protein P53, Antigen NY-CO-13, Transformation-Related Prot
    Entrez ID:
    673; 7157
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    7ms
    The Relationship of Microsatellite Instability with BRAF and p53 Mutations and Histopathological Parameters in Colorectal Adenocarcinoma. (PubMed, Ann Ital Chir)
    In colorectal adenocarcinoma, MSI and BRAF mutation are associated with parameters, indicating the host immune response and prognostic histopathological parameters, including tumor size and histological grade. The evaluation of MSI status and BRAF mutation can be particularly informative for predicting the prognosis and guiding the treatment management in poorly differentiated colorectal adenocarcinoma. Understanding the mechanisms of molecular carcinogenesis in colorectal carcinoma and organizing treatment algorithms based on molecular foundations will increase the success of the treatment.
    Journal • Microsatellite instability
    |
    BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • MSI (Microsatellite instability) • MLH1 (MutL homolog 1) • MSH6 (MutS homolog 6) • MSH2 (MutS Homolog 2) • PMS2 (PMS1 protein homolog 2)
    |
    TP53 mutation • BRAF mutation • PMS2 mutation • BRAF mutation + TP53 mutation
    8ms
    Relevance of mutations in protein deubiquitinases genes and TP53 in corticotroph pituitary tumors. (PubMed, Front Endocrinol (Lausanne))
    Changes in protein deubiquitinases genes appear to be favorable prognostic factors in CD. TP53 mutations are rare, occur in both functioning and silent tumors and are related to poor clinical outcome in CD.
    Journal
    |
    BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53)
    |
    TP53 mutation • BRAF mutation • TP53 expression • BRAF mutation + TP53 mutation
    over1year
    Predicting microsatellite instability and key biomarkers in colorectal cancer from H&E-stained images: achieving state-of-the-art predictive performance with fewer data using Swin Transformer. (PubMed, J Pathol Clin Res)
    Our findings indicate that Swin-T could be 5-10 times more efficient than existing algorithms for MSI prediction based on ResNet18 and ShuffleNet. Furthermore, the Swin-T models demonstrated their capability in accurately predicting MSI and BRAF mutation status, which could exclude and therefore reduce samples before subsequent standard testing in a cascading diagnostic workflow, in turn reducing turnaround time and costs.
    Journal • Microsatellite instability
    |
    BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • MSI (Microsatellite instability)
    |
    TP53 mutation • BRAF mutation • BRAF mutation + TP53 mutation