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    GENE:

    BPIFB2 (BPI Fold Containing Family B Member 2)

    i
    Other names: BPIFB2, BPI Fold Containing Family B Member 2, Bactericidal/Permeability-Increasing Protein-Like 1, LPLUNC2, Long Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 2, BPI Fold-Containing Family B Member 2, BPI-Like 1, C20orf184, BPIL1, RYSR
    over1year
    The m6A and immune regulatory gene signature predicts the prognosis and correlates with immune infiltration of head and neck squamous cell carcinoma. (PubMed, Heliyon)
    The risk score emerges as a potent prognostic biomarker and predictive metric for HNSC patients. A thorough assessment of m6A and immune regulatory genes in HNSC will augment our comprehension of the tumor immune microenvironment and facilitate the advancement of HNSC therapeutics.
    Journal • Gene Signature
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    MUC5B (Mucin 5B, Oligomeric Mucus/Gel-Forming) • BPIFB2 (BPI Fold Containing Family B Member 2)
    almost2years
    Integrative analyses of bulk and single-cell transcriptomics reveals the infiltration and crosstalk of cancer-associated fibroblasts as a novel predictor for prognosis and microenvironment remodeling in intrahepatic cholangiocarcinoma. (PubMed, J Transl Med)
    This study reveals the key role of fibroblasts - oncocytes interaction in the remodeling of the immunosuppressive microenvironment in intrahepatic cholangiocarcinoma. Subsequently, it may trigger cascade activation of downstream signaling pathways such as PI3K-AKT and Notch in tumor, thus initiating tumorigenesis. Targeted drugs aimed at disrupting fibroblasts-tumor cell interaction, along with associated enrichment pathways, show potential in mitigating the immunosuppressive microenvironment that facilitates tumor progression.
    Journal
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    WT1 (WT1 Transcription Factor) • BPIFB2 (BPI Fold Containing Family B Member 2)
    almost4years
    BPIFB2 is highly expressed in "cold" lung adenocarcinoma and decreases T cell chemotaxis via activation of the STAT3 pathway. (PubMed, Mol Cell Probes)
    Our study indicated that BPIFB2 was highly expressed in patients presenting with a cold tumor of lung adenocarcinoma. BPIFB2 knockdown increased the expression of CCL5 and the number of chemotactic CD8+T cells in lung adenocarcinoma. BPIFB2 may thus be considered an important target for immunotherapy.
    Journal • IO biomarker
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    CD8 (cluster of differentiation 8) • STAT3 (Signal Transducer And Activator Of Transcription 3) • CCL5 (Chemokine (C-C motif) ligand 5) • BPIFB2 (BPI Fold Containing Family B Member 2)