Bowens Disease

P2, N=25, Recruiting, Jonsson Comprehensive Cancer Center | Trial completion date: Jan 2027 --> Jan 2028 | Trial primary completion date: Jan 2026 --> Jan 2027

Among EMPD cases, perivulvar (n=10) and periscrotal (n=5) cases were consistently positive, whereas perianal lesions (n=10) showed no/weak expression. In summary, TRPS1 demonstrates universal expression in mammary PD of all ER/HER2 subgroups and in Toker cells, and corroborates recent reports regarding the utility of TRPS1 in site-of-origin studies.

Compared to normal epidermis, AK and SCCis exhibited increased Rb and p53 expression, whereas MCCis demonstrated loss of expression of both tumor suppressors. These findings suggest that dual downregulation of Rb and p53 may drive select cases of MCCis in sun-damaged skin.

In keratinocytes, BMRGs such as integrins (ITGB1, ITGA3, ITGA6), laminins (LAMA3, LAMC1), CD44, and FN1 were upregulated in cSCC compared to AK or BD (adjusted p < 0.05); in fibroblasts, BMRGs including ITGB1, ITGAV, LUM, BGN, SDC1, and FN1 were upregulated in cSCC (adjusted p < 0.05), suggesting their collective role in BM breaching and invasion, as well as a higher risk of BD. This study provides novel biological insights into the differentiation of progression pathways from AK or BD to cSCC, as well as potential targets for therapeutic intervention.

However, the current case is the first documented loss of MMR. Both cases presented with invasive disease ranging in depth from 3-5 mm, and positive lymph nodes emphasizing on the urgent need to further explore prognostic factors of this rare entity and to differentiate it from other acantholytic lesions, such as squamous cell carcinoma in situ and other acantholytic dermatoses.

From the high rate of poor outcomes evident in our series, we propose that wide local excision, postoperative adjuvant radiotherapy and follow-up imaging surveillance are justified. However, further studies are now required to better establish treatment guidelines for this rare aggressive adnexal tumour.

Immunostaining with CD138 proved effective in confirming plasma cell percentages within inflammatory infiltrates in most cases, revealing a higher proportion than initially suspected in some instances. Notably, plasma cells frequently localized preferentially in the lower portion of the infiltrate. This finding underscores the potential for superficial biopsies to yield misleading assessments of the infiltrate's nature.

It was more extensive in poorly differentiated areas and showed an inverse correlation with the proliferation rate. Our histopathologic, immunohistochemical and genetic findings provide further evidence that Bowen disease may act as a precursor for the rosette-forming component of the Wnt/β-catenin-activated carcinoma and that there is an inverse correlation between CDX2 expression and the proliferation rate.

In light of the patient's refusal of surgical intervention, she was treated with topical imiquimod 5% cream thrice weekly for 16 weeks, with moderate clinical improvement...A clinico-dermoscopic-pathologic correlation is crucial to avoid misdiagnosis and ensure timely treatment. Regular follow-up is recommended to monitor therapeutic response and detect any future neoplastic transformation.

Nipple lesions in the setting of prior radiation should raise concern for SCCIS. Clinicians should be aware of this rare, but potential sequelae in patients with a history of breast cancer treated with breast conserving therapy and nipple complaints.

We suggest COL6A1 and ITGA5 promote the invasive and metastatic property of SCC. We also uncovered how SCC recruits Tregs via the CXCL16/CXCR6 axis to create a TME favorable for its survival. These molecules can be used as potential therapeutic targets for treatment of SCC.

The results of the previous part of this research indicate that MMP-2 expression is more intense in lesions of actinic keratosis compared to normal tissues and to keratoacanthoma or Bowen's disease lesions, inversely proportional to the histopathological degree of dysplasia. Monitoring metalloproteinase activity in dysplastic epithelium may improve the detection of malignant transformation and guide treatment decisions.