Bone Cancer

P2, N=818, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: May 2026 --> May 2027 | Trial primary completion date: May 2026 --> May 2027

P2/3, N=100, Recruiting, Synox Therapeutics Limited | Active, not recruiting --> Recruiting

However, interferon-γ treatment did not induce TBXT (brachyury) expression in chordoma cells. Together, these data reveal strong associations between transcriptional states, metabolic profiles, and immune infiltration in chordomas.

Giant cell tumor of bone (GCTB) is an intermediate bone neoplasm defined by recurrent H3F3A mutations and limited systemic treatment options beyond denosumab...Functionally, 3D culture generally reduced sensitivity to many agents while preserving compound-dependent vulnerabilities. These results establish culture dimensionality as a key determinant of therapeutic susceptibility in GCTB PDCs and support incorporating proteome-informed 3D models into translational pipelines to prioritize clinically relevant drug candidates and biomarkers.

This study establishes a spinal chordoma PDO platform for functional precision oncology. Our findings identify a TP53-dependent DNA-damage vulnerability engaged by gemcitabine in patient-derived three-dimensional models, supporting biomarker-informed hypothesis generation rather than routine chemotherapy in unselected patients. This PDO-based approach provides a translational framework for exploring pathway-defined therapeutic susceptibilities in rare tumors such as chordoma.

It also emphasizes the critical role of histopathological examination in distinguishing chordomas from other clival lesions, such as ecchordosis physaliphora (EP). Gross total resection (GTR) should be performed when feasible, and histologic evidence of bone invasion can be an important diagnostic clue for chordomas.

CONCLUSIONS This case illustrates 3 critical clinical lessons: (1) NOF in adults requires heightened suspicion for aggressive bone tumors due to atypical imaging features and absence of expected involution; (2) Biopsy is mandatory for radiologically indeterminate lesions to avoid misdiagnosis and overtreatment; and (3) Surgical indication in adult NOF should be based on lesion size (>33 mm), cortical integrity, and fracture risk rather than symptoms alone. Prophylactic stabilization with bone cement provides immediate mechanical strength in mature bone.

Ki-67 labeling was confined to a subset of cytokeratin-positive cells at the periphery of the nodules, indicating that peripheral proliferation contributes to the exophytic growth pattern. This report describes a case of cervical chordoma with a unique exophytic presentation in a ferret.

This case highlights everolimus-associated hypertriglyceridemia in a lung transplant recipient and underscores the need for tight lipid monitoring and early immunosuppression adjustment when severe dyslipidemia emerges.

P4, N=60, West China Hospital , Sichuan University; West China Hospital , Sichuan University

This case is discussed within the context of a comprehensive narrative review highlighting the distinct biological behavior of calvarial GCTB compared to skull-base lesions, the critical importance of achieving gross total resection, and the emerging role of molecular diagnosis (H3F3A G34W mutation) and adjuvant therapies including denosumab. Calvarial GCTB offers superior surgical accessibility and prognosis compared to skull-base counterparts, with appropriately aggressive resection typically achieving cure without need for radiotherapy, thereby avoiding the well-documented risk of radiation-induced malignant transformation.

Our case emphasises that intra-articular NF is a rare entity that can mimic more common intra-articular tumours. The detection of USP6 on histopathological analysis allows accurate diagnosis and treatment.