P1/2 | "Part 1A is a single-agent dose escalation (accelerated titration) of BNT411 in patients with metastatic or unresectable solid tumors that have exhausted available treatment options, with bifurcation to Part 1B, a dose escalation of BNT411 in combination with atezolizumab, carboplatin and etoposide in patients with chemotherapy-naïve extensive-stage small cell lung cancer (ES-SCLC), followed by expansion cohorts (Part 2). Updated data will be presented, including combination treatment in the first-line setting of ES-SCLC. Trial Registration Clinicaltrials.gov: NCT04101357"
3 years ago
PK/PD data • P1/2 data • Clinical
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CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma)
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Tecentriq (atezolizumab) • carboplatin • etoposide IV • BNT411