BMP6 (Bone Morphogenetic Protein 6)

Additionally, halofuginone decreased hepcidin expression in mice subjected to acute inflammation. These findings establish halofuginone as a potential therapeutic for mitigating hepcidin-driven iron restriction in anemic disorders.

Our study characterizes the molecular and clinical distinctions between ecDNA-negative and ecDNA-positive HCC and establishes a clinically applicable gene signature for patient prognosis. These findings advance our understanding of ecDNA-driven tumor heterogeneity and provide potential strategies for personalized HCC management.

Functionally, overexpression of IGF2BP2 in skeletal muscle satellite cells (SMSCs) was associated with significant changes in the expression of several genes linked to muscle development and signaling pathways, including upregulation of IGF1, EGFR, FGF19, BMP6, BMP2, ACVR1C and WNT5A and downregulation of MYBPC3, NODAL, HOXD13, TNXB, and ADD2 (Padj < 0.01). Furthermore, protein-protein interaction (PPI) network analysis of these genes suggests that IGF2BP2 may coordinate key genes, contributing to its potential role in skeletal muscle development in geese.

BMP6 also directly inhibited MM cell proliferation and suppressed IL6-induced growth. These findings highlight BMP6 as a distinct multifunctional regulator warranting further investigation as a potential therapeutic approach, while establishing the humanized model as a valuable platform for dissecting tumor-bone interactions in MM.

Multivariable proportional hazard analysis using the Cohort 2a dataset revealed that the combination of BMP6 and OLFM1 status predicted recurrence-free survival. In conclusion, we found that low BMP6/OLFM1 gene status is a potential biomarker to identify high-risk pStage I pure solid non-squamous NSCLC patients after pulmonary resection.

NEAT1 inhibits apoptosis and promotes proliferation and migration of OGC through the miR-130a-3p/BMP6 axis, which may improve oocyte quality in patients with DOR. As such, NEAT1 may be a potential prognostic biomarker and therapeutic target for DOR.

Out of the significant common KEGG pathways observed between PD and melanoma, tryptophan metabolism, steroid biosynthesis, peroxisome proliferator-activated receptor (PPAR) signaling and arginine biosynthesis were directly related to the pathogenesis and progression of the two diseases. Therefore, these findings have elucidated the involvement of multiple genes and pathways in the association of PD and melanoma.

BMP2 and BMP6 expression was quantified using reverse transcription-quantitative PCR post-RNA extraction from bone marrow mononuclear cells derived from patients with MM and healthy donors. According to the observations in a group of patients with newly diagnosed MM, neither BMP2 nor BMP6 were able to serve as prognostic biomarkers for patients.

This case highlights the diagnostic complexity of plasmablastic plasmacytoma presenting as the initial manifestation of plasma cell myeloma. It underscores the necessity of a thorough evaluation, including bone marrow biopsy, to accurately differentiate plasmablastic transformation from PBL and ensure accurate diagnosis and appropriate management.

UPF1 inhibited cervical cancer cell migration and invasion through the regulation of nonsense-mediated decay of BMP6 and lncRNA WAKMAR2.

BMP6 upregulation induces gastric cancer cell ferroptosis and sensitizes cells to doxorubicin therapy. Our findings provide a therapeutic strategy in gastric cancer.

FIN56 induces ferroptosis in HCC cells, leading to the secretion of ANG. The secreted ANG acts as a critical signaling molecule, activating the BMP6/ID1 pathway in HUVECs and contributing to tumor microenvironment regulation.