^
BIOMARKER:

BMI1 overexpression

i
Other names: BMI1, PCGF4, RNF51, BMI1 proto-oncogene, polycomb ring finger
Entrez ID:
Related biomarkers:
3ms
circBMI1-Eca109 cells were more sensitive to 5-fluorouracil and cisplatin, and tumor volume of nude mice in circBMI1-Eca109 group was smaller (P < 0.05). Overexpression of circ-BMI1 inhibited proliferation, migration, colony formation of Eca109 cells, and tumor growth of Eca109 cells in nude mice. circ-BMI1 may be a potential target for diagnosis and treatment in esophageal cancer.
Journal
|
BMI1 (BMI1 proto-oncogene, polycomb ring finger)
|
BMI1 overexpression
|
cisplatin • 5-fluorouracil
3ms
The response rate to the first-line chemotherapy of cisplatin and gemcitabine does not exceed 50%. Moreover, suppression of P-glycoprotein by miR-3682-3p mimics or its inhibitor XR-9576, could significantly reverse chemoresistance of T24/DDP&GEM cells. These results provided a novel insight into a portion of the mechanism underlying BMI1-mediated chemoresistance in bladder cancer.
Journal
|
ABCB1 (ATP Binding Cassette Subfamily B Member 1) • BMI1 (BMI1 proto-oncogene, polycomb ring finger)
|
BMI1 overexpression
|
cisplatin • gemcitabine
6ms
Finally, expression of BMI1 increased the phosphorylation of STAT3, which is important for cell proliferation, survival, migration, and invasion. Therefore, we suggest that AL plays a pivotal role in inhibiting BMI1 in the tumorigenesis of cervical cancer and is a potential therapeutic agent for cervical cancer.
Journal
|
STAT3 (Signal Transducer And Activator Of Transcription 3) • BMI1 (BMI1 proto-oncogene, polycomb ring finger) • VIM (Vimentin)
|
BMI1 expression • BMI1 overexpression • VIM expression
8ms
A rescue assay showed that overexpression of WT1, BMI1, and XIAP offset the antitumor effect of miR-203a. Conclusion, EGR1 positively regulated the expression of miR-203a, thus relieving the inhibition of miR-203a on the translation of its target genes (WT1, BMI1, and XIAP) and affecting the proliferation of K562 cells.
Journal
|
WT1 (WT1 Transcription Factor) • BMI1 (BMI1 proto-oncogene, polycomb ring finger) • XIAP (X-Linked Inhibitor Of Apoptosis) • EGR1 (Early Growth Response 1)
|
BMI1 overexpression
9ms
The study evidenced that miR-381 may act as a beneficiary biomarker in BCa patients. Up-regulation of miR-381 suppresses BCa development both in vivo and in vitro through BMI1 down-regulation and the Rho/ROCK inactivation.
Journal
|
BMI1 (BMI1 proto-oncogene, polycomb ring finger)
|
BMI1 overexpression