^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    BLNK (B Cell Linker)

    i
    Other names: BLNK, B Cell Linker, SLP-65, SLP65, BASH, B-Cell Adapter Containing A SH2 Domain Protein, BLNK-S, Bca, Src Homology [SH2] Domain-Containing Leukocyte Protein Of 65 KD, Src Homology 2 Domain-Containing Leukocyte Protein Of 65 KDa, B-Cell Adapter Containing A Src Homology 2 Domain Protein, B Cell Adaptor Containing SH2 Domain, Cytoplasmic Adapter Protein, B-Cell Linker Protein, B-Cell Activation, Ly57, AGM4, LY57
    Associations

    News

    Trials
    4ms
    BLNK as an important prognostic indicator for survival in pediatric classic hodgkin lymphoma patients: a single-center retrospective study. (PubMed, Ann Hematol)
    Jude Stages III-IV, the absence of a giant tumor lesion, a chemotherapy regimen (2), a CRP concentration >10.2 mg/L, a B lymphocyte count >18.5 × 10^6/L, an IgG concentration >6.91 g/L, a neutrophil count ≤ 5.6 × 10^9/L, a lymphocyte count >0.49 × 10^9/L, a platelet count >298.5 × 10^9/L, a PLR >199.31, and an NLR >3.17 had a greater effect on OS in the BLNK-negative group. Decreased BLNK expression predicts prolonged PFS among patients with cHL. The validated nomogram integrating BLNK and clinical parameters provides potential predictive value for PFS of cHL. No Clinical trial registration.
    Retrospective data • Journal
    |
    BLNK (B Cell Linker)
    5ms
    YBX1 modulates humoral immunity through post-transcriptional regulation in B cells. (PubMed, Front Immunol)
    Together, these findings reveal an unexpected, non-redundant role for YBX1 in regulating immune effector functions. By enhancing immunoglobulin and myeloid inflammatory mediator mRNA translation, YBX1 emerges as a contributor to immune homeostasis and possibly tumor immune evasion by regulating the expression of immunomodulatory factors in immune and malignant cells alike.
    Journal
    |
    PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • YBX1 (Y-Box Binding Protein 1) • IL4 (Interleukin 4) • NOS2 (Nitric Oxide Synthase 2) • BLNK (B Cell Linker)
    5ms
    Differential expression profiles of immunoregulatory genes in anaplastic thyroid carcinomas with a coexistent papillary carcinoma component. (PubMed, Virchows Arch)
    In conclusion, ATC displays high levels of expression of immunoregulatory genes as compared to PDTC. Moreover, a subset of genes and miRNAs is significantly de-regulated along progression from PTC to ATC, suggesting their potential role as biomarkers and involvement in key functional mechanisms.
    Journal
    |
    EPCAM (Epithelial cell adhesion molecule) • MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) • RIPK2 (Receptor Interacting Serine/Threonine Kinase 2) • BLNK (B Cell Linker) • ITGA5 (Integrin Subunit Alpha 5) • ITGB1 (Integrin Subunit Beta 1)
    |
    nCounter® PanCancer Immune Profiling Panel
    1year
    Transcriptomic Profiling Reveals Key Biomarkers in Primary Refractory and Early Relapse Classical Hodgkin Lymphoma (ASH 2024)
    Furthermore, increased activity of macrophages and reduced expression of B-cells support previous studies underlining their involvement in treatment resistance. Despite limitations in sample size, these findings shed light on the mechanisms behind resistance and early relapse in cHL, which could help guide the development of targeted therapies and potentially improve early risk assessment.
    PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • CD20 (Membrane Spanning 4-Domains A1) • JAK1 (Janus Kinase 1) • CD22 (CD22 Molecule) • PAX5 (Paired Box 5) • CD68 (CD68 Molecule) • CD79A (CD79a Molecule) • CSF1R (Colony stimulating factor 1 receptor) • CCL3 (C-C Motif Chemokine Ligand 3) • MS4A1 (Membrane Spanning 4-Domains A1) • TNFRSF13C (TNF Receptor Superfamily Member 13C) • BLNK (B Cell Linker) • C1QB (Complement C1q B Chain) • POU2AF1 (POU Class 2 Homeobox Associating Factor 1) • TLR2 (Toll Like Receptor 2)
    |
    PD-L1 expression • CD22 expression
    |
    nCounter® PanCancer Immune Profiling Panel
    over1year
    Construction of a five-gene-based prognostic model for relapsed/refractory acute lymphoblastic leukemia. (PubMed, Hematology)
    We have developed a risk prediction model for pediatric R/R ALL utilizing the genes BAG2, EPHA4, FBXO9, SNX10, and WNK1. This model provides a scientific foundation for early identification of R/R ALL in children.
    Journal • IO biomarker
    |
    PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • SOX2 • CD27 (CD27 Molecule) • CD3D (CD3d Molecule) • LCK (LCK Proto-Oncogene, Src Family Tyrosine Kinase) • WNK1 (WNK Lysine Deficient Protein Kinase 1) • CD3G (CD3 Gamma Subunit Of T-Cell Receptor Complex) • NANOG (Nanog Homeobox) • RASGRP1 (RAS Guanyl Releasing Protein 1) • VPREB1 (V-Set Pre-B Cell Surrogate Light Chain 1) • BLNK (B Cell Linker) • E2F1 (E2F transcription factor 1) • EPHA4 (EPH Receptor A4) • FBXO9 (F-Box Protein 9) • HOXB4 (Homeobox B4)
    over1year
    BLNK negatively regulates innate antifungal immunity through inhibiting c-Cbl-mediated macrophage migration. (PubMed, Proc Natl Acad Sci U S A)
    This resistance is attributed to the increased infiltration of Ly6C+ macrophages into renal tissue. These findings unveil a previously unrecognized role of BLNK for the negative regulation of macrophage migration through inhibiting CLR-mediated podosome ring formation during fungal infections.
    Journal
    |
    SYK (Spleen tyrosine kinase) • BLNK (B Cell Linker)
    over1year
    Next-generation sequencing of primary testicular lymphoma and relapse in the glans penis after prophylactic radiation therapy: a rare case report. (PubMed, Diagn Pathol)
    We found the same variant allele fraction in four somatic genes (MYD88, IL7R, BLNK, and FLT3) at similar frequencies, indicating that the glans penile lymphoma had the same origin as the PTL. To the best of our knowledge, this is the first case report of PTL relapse in the glans penis.
    Journal • Next-generation sequencing
    |
    MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • IL7R (Interleukin 7 Receptor) • BLNK (B Cell Linker)
    almost2years
    Astragalus polysaccharides ameliorates experimental colitis by regulating memory B cells metabolism. (PubMed, Chem Biol Interact)
    These mRNA expressions were validated through quantitative polymerase chain reaction (qPCR) and immunohistochemistry. These findings revealed that APS effectively restored MBCs and their balance to ameliorate DSS-induced colitis, which was potentially realized via promoting mitochondrial metabolism to maintain MBCs activation.
    Journal • IO biomarker
    |
    BCL6 (B-cell CLL/lymphoma 6) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • PAX5 (Paired Box 5) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • TGFB1 (Transforming Growth Factor Beta 1) • FOXP3 (Forkhead Box P3) • PRDM1 (PR/SET Domain 1) • CD40 (CD40 Molecule) • BLNK (B Cell Linker)
    2years
    An inflammatory response-related gene signature can predict the prognosis and impact the immune infiltration of multiple myeloma. (PubMed, Clin Exp Med)
    Our study explores the potential application value of IRRGs in MM. These findings may provide new insights into the treatment for MM patients.
    Journal • Gene Signature
    |
    BIRC3 (Baculoviral IAP repeat containing 3) • VCAM1 (Vascular Cell Adhesion Molecule 1) • BLNK (B Cell Linker) • CD81 (CD81 Molecule)
    2years
    Genetic and Cytometric Characteristics of Pediatric B-Other Acute Lymphoblastic Leukemia Cohort (ASH 2023)
    "Our study shows population-based frequencies of novel ALL subtypes, including both recurrent and novel genetic aberrations. This data widens our knowledge on the interplay between molecular aberrations and clinical course of the disease and provides clues for diagnostics optimization."
    Clinical
    |
    ABL1 (ABL proto-oncogene 1) • BCR (BCR Activator Of RhoGEF And GTPase) • FGFR1 (Fibroblast growth factor receptor 1) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • RUNX1 (RUNX Family Transcription Factor 1) • CD74 (CD74 Molecule) • KMT2A (Lysine Methyltransferase 2A) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • ETV6 (ETS Variant Transcription Factor 6) • CRLF2 (Cytokine Receptor Like Factor 2) • PAX5 (Paired Box 5) • STAT3 (Signal Transducer And Activator Of Transcription 3) • IL2RA (Interleukin 2 receptor, alpha) • CD34 (CD34 molecule) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • IL7R (Interleukin 7 Receptor) • CRKL (CRK Like Proto-Oncogene, Adaptor Protein) • TCF3 (Transcription Factor 3) • PBX1 (PBX Homeobox 1) • CHD1 (Chromodomain Helicase DNA Binding Protein 1) • SOCS1 (Suppressor Of Cytokine Signaling 1) • CD99 (CD99 Molecule) • SSBP2 (Single Stranded DNA Binding Protein 2) • BLNK (B Cell Linker)
    |
    FGFR1 fusion • MLL fusion
    |
    FusionPlex® Dx
    2years
    The Unique BCR Inhibiting Properties of BMS-986205 in Chronic Lymphocytic Cells (ASH 2023)
    Efforts are underway to identify the proteome-wide direct target of BMS in CLL cells. In conclusion, our limited and preliminary data suggest that BMS could be considered as a potential therapeutic strategy to target CLL cells with a double hit: by blocking the pro-survival effect of BCR signaling, one of the driving forces for CLL cell survival and proliferation, and by inhibiting IDO1/kynurenine action to restore sensitivity to key leukemia treatments.
    IO biomarker
    |
    SYK (Spleen tyrosine kinase) • CD79A (CD79a Molecule) • PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22) • BLNK (B Cell Linker)
    |
    IDO1 expression
    |
    linrodostat (BMS-986205)
    over2years
    Plumbagin has an inhibitory effect on the growth of TSCC PDX model and it enhances the anticancer efficacy of cisplatin. (PubMed, Aging (Albany NY))
    Plumbagin exhibits an inhibitory effect on the growth of the PDX model of TSCC. Moreover, plumbagin enhances the inhibitory effects of cisplatin.
    Journal
    |
    AXL (AXL Receptor Tyrosine Kinase) • VOPP1 (VOPP1 WW Domain Binding Protein) • BLNK (B Cell Linker) • DUSP1 (Dual Specificity Phosphatase 1)
    |
    cisplatin