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    BIOMARKER:

    BLMH overexpression

    i
    Other names: Bleomycin Hydrolase, BH, BLM Hydrolase, BMH, BLMH
    Entrez ID:
    642
    2years
    H4K20ME1-MEDIATED EPIGENETIC DYSREGULATION OF MTOR/AUTOPHAGY INCREASES AMYLOID BETA ACCUMULATION AND COGNITIVE/NEUROMOTOR DEFICITS IN HYPERHOMOCYSTEINEMIC AND BLEOMYCIN HYDROLASE-DEFICIENT MICE (ADPD 2022)
    Blmh deficiency and HHcy dysregulated mTOR signaling/autophagy via increased mTOR promoter occupancy by Phf8-dependent H4K20me1, which caused Aβ accumulation and ultimately impaired cognition and neuro-motor activities. Supported by NCN grants 2016/21/D/NZ4/00478, 2016/23/N/NZ3/01216, 2018/29/B/NZ4/00771, 2019/33/B/NZ4/01760.
    Preclinical
    |
    BLMH (Bleomycin Hydrolase)
    |
    BLMH overexpression
    |
    bleomycin