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    BIOMARKER:

    BIRC5 mutation

    i
    Other names: BIRC5, API4, EPR-1, survivin, Baculoviral IAP repeat containing 5
    Entrez ID:
    332
    Related biomarkers:
    Expression
    Mutation
    over2years
    FL118, acting as a 'molecular glue degrader', binds to dephosphorylates and degrades the oncoprotein DDX5 (p68) to control c-Myc, survivin and mutant Kras against colorectal and pancreatic cancer with high efficacy. (PubMed, Clin Transl Med)
    DDX5 is a bona fide FL118 direct target and can act as a biomarker for predicting PDAC and CRC tumour sensitivity to FL118. This would greatly impact FL118 precision medicine for patients with advanced PDAC or advanced CRC in the clinic. FL118 may act as a 'molecular glue degrader' to directly glue DDX5 and ubiquitination regulators together to degrade DDX5.
    Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • MCL1 (Myeloid cell leukemia 1) • BIRC3 (Baculoviral IAP repeat containing 3) • BIRC5 (Baculoviral IAP repeat containing 5) • DDX5 (DEAD-Box Helicase 5) • XIAP (X-Linked Inhibitor Of Apoptosis)
    |
    KRAS mutation • MCL1 expression • DDX5 overexpression • BIRC5 mutation
    |
    FL118
    3years
    Systematic analysis of gene expression alteration of BIRC5/survivn in gastric cancer. (ASCO-GI 2022)
    Our results demonstrate that data mining efficiently reveals information about BIRC5/survivin expression and potential regulatory networks in gastric cancer, laying a foundation for further study of the role of BIRC5/survivin in carcinogenesis and tumor immunotherapy.
    PD(L)-1 Biomarker • IO biomarker
    |
    HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • IFNG (Interferon, gamma) • LAG3 (Lymphocyte Activating 3) • MSH6 (MutS homolog 6) • MSH2 (MutS Homolog 2) • PMS2 (PMS1 protein homolog 2) • BIRC5 (Baculoviral IAP repeat containing 5) • CD4 (CD4 Molecule)
    |
    HER-2 expression • LAG3 expression • BIRC5 expression • BIRC5 mutation • MSH6 expression
    over3years
    Localization matters: nuclear-trapped Survivin sensitizes glioblastoma cells to temozolomide by elevating cellular senescence and impairing homologous recombination. (PubMed, Cell Mol Life Sci)
    Although tumors of high-grade glioma patients expressed majorly nuclear Survivin, they exhibited rarely NES mutations which did not correlate with survival. Based on our in vitro and xenograft data, Survivin nuclear trapping would facilitate glioma response to TMZ.
    Journal
    |
    RAD51 (RAD51 Homolog A) • BIRC5 (Baculoviral IAP repeat containing 5) • PCNA (Proliferating cell nuclear antigen) • NES (Nestin)
    |
    BIRC5 expression • BIRC5 mutation
    |
    temozolomide