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    BIOMARKER:

    BICD1 overexpression

    i
    Other names: BICD1, BICD Cargo Adaptor 1, Protein Bicaudal D Homolog 1, Bic-D 1, Cytoskeleton-Like Bicaudal D Protein Homolog 1, Bicaudal D (Drosophila) Homolog 1, Bicaudal D Homolog 1 (Drosophila), Bicaudal D Homolog 1, BICD
    Entrez ID:
    636
    24d
    Baicalein promotes KDM4E to induce BICD1 and inhibit triple-negative breast cancer progression by blocking PAR1 signaling. (PubMed, Mol Carcinog)
    Knockdown of KDM4E strengthened the PAR1-dependent activity of TNBC cells in response to thrombin activation, whereas TNBC progression activated by PAR1 signaling was blocked by combined overexpression of BICD1. Taken together, our data indicate that baicalein-promoted KDM4E enhanced the expression of BICD1 and activated the inhibitory effect of BICD1 on PAR1 signaling, thereby inhibiting TNBC progression.
    Journal
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    BICD1 (BICD Cargo Adaptor 1)
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    BICD1 overexpression