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    BIOMARKER:

    BCR-FGFR1 fusion

    i
    Other names: BCR, BCR Activator Of RhoGEF And GTPase, BCR, RhoGEF And GTPase Activating Protein, Breakpoint Cluster Region Protein, Renal Carcinoma Antigen NY-REN-26, Breakpoint Cluster Region, D22S11, BCR1, BCR/FGFR1 Chimera Protein, FGFR1/BCR Chimera Protein, D22S662, ALL, CML, PHL, FGFR1, BFGFR, CD331, CEK, FLG, FLT2, H2, H3, H4, H5, KAL2, N-SAM, Fibroblast growth factor receptor 1
    Entrez ID:
    613; 2260
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over2years
    Proteomic analysis reveals dual requirement for Grb2 and PLCγ1 interactions for BCR-FGFR1-Driven 8p11 cell proliferation. (PubMed, Oncotarget)
    The effects on BCR-FGFR1-stimulated cell proliferation were examined using the PLCγ1 inhibitor U73122, and the irreversible FGFR inhibitor futibatinib (TAS-120), both of which demonstrated efficacy. An absolute requirement is demonstrated for the dual binding partners Grb2 and PLCγ1 in BCR-FGFR1-driven cell proliferation, and new proteins such as ECSIT, USP15, GPR89, GAB1, and PTPN11 are identified as key effectors for hematopoietic transformation by BCR-FGFR1.
    Journal
    |
    BCR (BCR Activator Of RhoGEF And GTPase) • FGFR1 (Fibroblast growth factor receptor 1) • PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11)
    |
    FGFR1 fusion • BCR-FGFR1 fusion
    |
    Lytgobi (futibatinib)
    4years
    [VIRTUAL] A Novel Multimodal Next Generation Sequencing Assay with Total Nucleic Acid Input to Provide Comprehensive Genomic Profiling for Hematologic Malignancies (ASH 2020)
    Conclusions : We developed a single tube TNA based workflow with a custom multimodal chemistry that simultaneously detects many DNA and RNA abnormalities in a cost effective and efficient way while reducing sample requirements. This unique TNA NGS assay provides comprehensive genomic profiling for hematologic malignancies and improves the diagnostic testing options for precise patient care.
    Next-generation sequencing • BRCA Biomarker
    |
    ABL1 (ABL proto-oncogene 1) • FGFR1 (Fibroblast growth factor receptor 1) • DNMT3A (DNA methyltransferase 1) • JAK2 (Janus kinase 2) • ASXL1 (ASXL Transcriptional Regulator 1) • BRCA (Breast cancer early onset) • U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1)
    |
    BCR-ABL1 fusion • U2AF1 mutation • FGFR1 fusion • JAK2 V617F • BCR-FGFR1 fusion