^
BIOMARKER:

BCL3 overexpression

i
Other names: BCL3, BCL3 Transcription Coactivator, Chronic Lymphatic Leukemia Protein, B-Cell Lymphoma 3-Encoded Protein, B-Cell Leukemia/Lymphoma 3, B-Cell Lymphoma 3 Protein, B Cell CLL/Lymphoma 3, Proto-Oncogene BCL3, BCL4, BCL3, Transcription Coactivato
Entrez ID:
1m
Our study shows that IL6 overexpression seems to be a key event in ESCC carcinogenesis, contributing to ESCC through a homogeneous antiapoptotic signalling via BCL3 overexpression, thus suggesting anti-IL6 therapies to be further considered for ESCC treatment. Finally, our data support the use of BCL3 mRNA expression as a potential biomarker for ESCC detection.
Journal
|
IL6 (Interleukin 6) • BCL3 (BCL3 Transcription Coactivator)
|
BCL3 overexpression • IL6 expression
6ms
We demonstrate that Bcl3 impacts pancreatic carcinogenesis by restraining CSC expansion and by curtailing an aggressive and metastatic tumor burden in PDAC across species. Levels of BCL3 expression are a useful stratification marker predicting subtype characterization in PDAC thereby, allowing for personalized therapeutic approaches.
Journal
|
BCL3 (BCL3 Transcription Coactivator)
|
BCL3 overexpression