BCL2 (B-cell CLL/lymphoma 2)

P2, N=35, Completed, Kite, A Gilead Company | Active, not recruiting --> Completed

Additionally, using the TCGA database, we found that these targets have diagnostic and prognostic significance in renal cancer. Our findings suggest that BCL2, CASP3, MMP9, SIRT1, and TNF may play crucial roles in both nephrotoxicity and renal cancer progression, offering new insights into the molecular mechanisms of 1,3-BD-induced renal injury and potential intervention targets.

P1/2, N=64, Recruiting, M.D. Anderson Cancer Center | Active, not recruiting --> Recruiting | N=11 --> 64

Notably, it also triggers mitophagy through PINK1/Parkin upregulation, offering dual mitochondrial-targeted cytotoxicity. These findings position [UDRu] as a next-generation Ru(II) complex with multitargeted action, holding significant promise for overcoming resistance in TNBC therapy.

Comprehensive imaging and histopathological evaluation are crucial for accurate diagnosis. Early detection and total resection contribute to favorable neurological outcomes in asymptomatic patients.

This case highlights the importance of considering cervical EMP in atypical cytology and suggests a possible link to chronic pessary-induced inflammation. Early diagnosis through histopathology and immunohistochemistry is essential.

The analysis revealed that IHC not only confirmed lineage specificity but also helped to identify aberrant antigen expression and proliferative indices characteristic of malignancy. Thus, we show the pivotal role of IHC in improving diagnostic accuracy, reducing misclassification and guiding appropriate therapeutic decisions in patients with lymphoid hyperplasia.

Western blot analysis of apoptosis-related proteins showed that BMSCs-Exos increased the Bcl-2 expression and reduced Bax expression and promoted phosphorylation of the Akt signaling pathway, which implied suppression of cellular apoptosis. In summary, our findings demonstrate that BMSCs-Exos promote RISI repair by regulating the inflammatory microenvironment, and inhibiting cell apoptosis.

WB and RT-qPCR analysis further confirmed this dual mechanism, revealing downregulation of key cell cycle regulators (Cyclin A/D and CDK2/4) and activation of the mitochondrial apoptotic pathway, characterized by an increased Bax/Bcl-2 ratio and caspase-3 activation. This study not only presents a sustainable strategy for utilizing Marsdenia tenacissimaresidue but also highlights the promise of polysaccharide-based nanodrugs in cancer therapy.

These findings related to MYOF-specific effects, as compared to MYON, emphasize that these differences are statistically significant and relevant to UF risk. It can shed insight on how phthalates exposures may impact UF pathogenesis and provide a basis for exploring targeted therapeutic strategies.

P=N/A, N=2000, Recruiting, Karius, Inc. | Not yet recruiting --> Recruiting

P2, N=28, Active, not recruiting, Patrick C. Johnson, MD | Recruiting --> Active, not recruiting