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    DRUG:

    BAY-885

    i
    Other names: BAY-885
    Associations

    News

    Trials
    Company:
    Bayer
    Drug class:
    ERK5 inhibitor
    Related drugs:
    Associations

    News

    Trials
    over2years
    BAY-885, a mitogen-activated protein kinase kinase 5 inhibitor, induces apoptosis by regulating the endoplasmic reticulum stress/Mcl-1/Bim pathway in breast cancer cells. (PubMed, Bioengineered)
    ER stress was induced in an ERK5 inhibition-dependent manner. These findings suggested that BAY-885 induced apoptosis in BC cells via ER stress/Mcl-1/Bim axis, suggesting that BAY-885 may serve as a therapeutic agent for BC.
    Journal
    |
    MCL1 (Myeloid cell leukemia 1)
    |
    BAY-885