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    BIOMARKER:

    BAX overexpression

    i
    Other names: BAX, BCL2L4, BCL2-associated X protein
    Entrez ID:
    581
    Related biomarkers:
    Expression
    Others
    1d
    New thiadiazolopyrimidine-ornamented pyrazoles as prospective anticancer candidates via suppressing VEGFR-2/PI3K/Akt signaling pathway: Synthesis, characterization, in-silico, and in-vitro studies. (PubMed, Int J Biol Macromol)
    Compound 8b significantly damaged the T47D (IC50 = 33.01 ± 2.2 μM) cells in comparison to Cisplatin (IC50 = 3.163 ± 1.7 μM)...Besides, compound 8b showed a notable decrease in the levels of nitric oxide (NO) production levels and stopped the cell cycle in the G0/G1 stage. These outcomes demonstrated that compound 8b adhered to Lipinski's rules and may serve as a potential candidate for future breast cancer treatments via obstructing the VEGFR2/PI3K/Akt signaling pathway, which in turn prevents metastasis, angiogenesis, and proliferation.
    Preclinical • Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein)
    |
    BCL2 overexpression • BAX expression • BAX overexpression
    |
    cisplatin
    19d
    The interaction of cinchonine and immunoglobulin G and the development of a nanocomplex with improved anti-breast cancer activity. (PubMed, Int J Biol Macromol)
    Finally, Cin-IgG NPs induce a greater effect on the overexpression of the Bax/Bcl-2 ratio and downregulation of PI3K/p-AKT compared to the free drug. In conclusion, this study shows that Cin has the potential to bind IgG as a human plasma protein, and its complexation into a NP form with IgG can boost its anti-BC effects.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • PI3K (Phosphoinositide 3-kinases)
    |
    BAX expression • BAX overexpression
    9ms
    Salvia officinalis L. exerts oncostatic effects in rodent and in vitro models of breast carcinoma. (PubMed, Front Pharmacol)
    In vitro analyses revealed significant anti-cancer effects of SPGE extract in MCF-7 and MDA-MB-231 cell lines (cytotoxicity, caspase-3/-7, Bcl-2, Annexin V/PI, cell cycle, BrdU, and mitochondrial membrane potential). Our study demonstrates the significant chemopreventive and treatment effects of salvia haulm using animal or in vitro BC models.
    Preclinical • Journal • IO biomarker
    |
    PTEN (Phosphatase and tensin homolog) • BCL2 (B-cell CLL/lymphoma 2) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • MIR155 (MicroRNA 155) • EPCAM (Epithelial cell adhesion molecule) • MIR21 (MicroRNA 21) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • MIR34A (MicroRNA 34a-5p) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • TGFB1 (Transforming Growth Factor Beta 1) • CASP7 (Caspase 7) • MIR210 (MicroRNA 210) • RASSF1 (Ras Association Domain Family Member 1) • ANXA5 (Annexin A5) • MIR145 (MicroRNA 145) • MIR22 (MicroRNA 22) • TIMP3 (TIMP Metallopeptidase Inhibitor 3)
    |
    BAX expression • CASP3 overexpression • BAX overexpression • EPCAM expression
    12ms
    Soloxolone methyl induces apoptosis and oxidative/ER stress in breast cancer cells and target cancer stem cell population. (PubMed, Turk J Biol)
    In mammospheres as 3D model, SM decreased stem cell properties and induced cell death. Taken together, SM may be a promising agent in the treatment of breast cancer, especially due to its antigrowth activity on CSCs.
    Journal • Cancer stem
    |
    BAX (BCL2-associated X protein) • CD24 (CD24 Molecule)
    |
    BAX expression • BAX overexpression
    over1year
    Acquired Resistance to Venetoclax plus Azacitidine in Acute Myeloid Leukemia: in vitro Models and Mechanisms. (PubMed, Biochem Pharmacol)
    Inhibition of glycolysis with 2-Deoxy-D-glucose re-sensitized the resistant cells to VEN+AZA. Overexpression of Mcl-1 or knockdown of Bax result in resistance to VEN+AZA. Our results provide insight into the molecular mechanisms contributing to VEN+AZA resistance and assist in the development of novel therapeutics to overcome this resistance in AML patients.
    Preclinical • Journal
    |
    MCL1 (Myeloid cell leukemia 1) • CD36 (thrombospondin receptor) • BAX (BCL2-associated X protein)
    |
    MCL1 expression • BAX expression • BAX overexpression
    |
    Venclexta (venetoclax) • azacitidine
    over1year
    Two staged phase II clinical trial of Eribulin monotherapy in advanced or recurrent cervical cancer. (PubMed, Gynecol Oncol)
    Eribulin shows modest activity in patients with recurrent/advanced cervical cancer with a favorable toxicity profile. Prior paclitaxel exposure is associated with decreased eribulin response. βII, βIII tubulin subtypes and BAX are predictors of response and survival. Eribulin may be an option for women with paclitaxel-naïve recurrent/advanced cervical cancer.
    P2 data • Clinical Trial,Phase II • Journal • Metastases
    |
    BAX (BCL2-associated X protein)
    |
    BAX expression • BAX overexpression
    |
    Avastin (bevacizumab) • cisplatin • gemcitabine • paclitaxel • Halaven (eribulin mesylate)
    over1year
    Dual targeting of BCL-2 and MCL-1 in the presence of BAX breaks venetoclax resistance in human small cell lung cancer. (PubMed, Br J Cancer)
    The current study reveals the subtype specificity of BCL-2 expression and sheds light on the mechanism of venetoclax resistance in SCLC. Additionally, we provide preclinical evidence that combined BCL-2 and MCL-1 targeting is an effective approach to overcome venetoclax resistance in high BCL-2-expressing SCLCs with intact BAX.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • POU2F3 (POU Class 2 Homeobox 3) • ASCL1 (Achaete-Scute Family BHLH Transcription Factor 1)
    |
    MCL1 overexpression • BCL2 expression • MCL1 expression • BAX expression • BAX overexpression
    |
    Venclexta (venetoclax) • S63845
    2years
    Genotoxic damage and apoptosis in rat glioma (F98) cell line following exposure to Bromuconazole. (PubMed, Neurotoxicology)
    Apoptotic cell death was confirmed through: positive Annexin-V/FITC-PI dyes, p53 and Bax overexpression, Bcl2 repression, an increase in Bax/BCL-2 ratios of the mRNA, mitochondrial membrane depolarization, and an increase of caspase-3 activity. All these results demonstrate that bromuconazole exerts its cytotoxic and genotoxic effects through apoptotic cell death, which could implicate mitochondria.
    Preclinical • Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • ANXA5 (Annexin A5)
    |
    BCL2 overexpression • BAX expression • BAX overexpression
    over2years
    Olmesartan medoxomil self-microemulsifying drug delivery system reverses apoptosis and improves cell adhesion in trinitrobenzene sulfonic acid-induced colitis in rats. (PubMed, Drug Deliv)
    Sulfasalazine exerted maximal colonic protective effects and almost completely reversed colonic damage, and OMSH showed nearly similar effects with non-significant differences in-between or compared with the normal control group. In conclusion, OMS could be a potential additive treatment for Crohn's disease colitis.
    Preclinical • Journal • IO biomarker
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CDH1 (Cadherin 1) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CASP9 (Caspase 9) • MMP9 (Matrix metallopeptidase 9)
    |
    BCL2 expression • CDH1 expression • BAX expression • BAX overexpression • BCL2/BAX ratio elevation
    over3years
    Anticancer Effects of Gold Nanoparticles by Inducing Apoptosis in Bladder Cancer 5637 Cells. (PubMed, Biol Trace Elem Res)
    Similarly, Hoechst staining indicates a remarkable increase in cells with apoptotic morphology after treating with AuNPs. Overall, our findings show that AuNPs significantly provoke ROS production, induce apoptosis, and suppress cell migration in bladder cancer 5637 cells.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CASP7 (Caspase 7)
    |
    BCL2 expression • BAX expression • BAX overexpression
    almost4years
    Ferutinin: A phytoestrogen from ferula and its anticancer, antioxidant, and toxicity properties. (PubMed, J Biochem Mol Toxicol)
    Besides, the lipid peroxidation of the liver tissue of mice was significantly reduced. According to the results, we suggest that ferutinin has the potential to be served as a selective anticancer compound for breast cancer treatment.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein)
    |
    BCL2 overexpression • BAX expression • BAX overexpression