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BIOMARKER:

BAX expression

i
Other names: BAX, BCL2L4, BCL2-associated X protein
Entrez ID:
Related biomarkers:
19h
Dog sperm cryopreservation using cryovials and different dilution steps. (PubMed, Cryo Letters)
The sperm frozen using cryovials, one step dilution and the deep freezer (Group 2) proved to be a simple and suitable cryopreservation method for dog sperm. https://doi.org/10.54680/fr24110110312.
Journal • IO biomarker
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BAX (BCL2-associated X protein)
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BCL2 expression • BAX expression
21h
Molybdenum and cadmium co-induce apoptosis and ferroptosis through inhibiting Nrf2 signaling pathway in duck (Anas platyrhyncha) testes. (PubMed, Poult Sci)
The most obvious changes of these indexes were observed in co-treated group. Altogether, the results announced that Mo or Cd or both evoked apoptosis and ferroptosis by inhibiting Nrf2 pathway in the testis of ducks, and co-exposure to Mo and Cd exacerbated these variations.
Journal • IO biomarker
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HMOX1 (Heme Oxygenase 1) • CASP3 (Caspase 3) • GPX4 (Glutathione Peroxidase 4) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • NQO1 (NAD(P)H dehydrogenase, quinone 1) • TFRC • ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) • SLC7A11 (Solute Carrier Family 7 Member 11) • FTL (Ferritin Light Chain) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)
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BCL2 expression • BAX expression • GPX4 expression • PTGS2 expression
2d
Harmaline induces apoptosis and inhibits migration in A2780 ovarian cancer cells in vitro. (PubMed, Physiol Rep)
MMP-2 and MMP-9's mRNA expression, gelatinase activity, and migration of A2780 cells also decreased by harmaline. These findings suggest that harmaline may have the potential to be a therapeutic drug for ovarian cancer by triggering apoptosis and suppressing invasion and migration.
Preclinical • Journal • IO biomarker
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TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • MMP2 (Matrix metallopeptidase 2) • BAX (BCL2-associated X protein) • MMP9 (Matrix metallopeptidase 9)
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BCL2 expression • TP53 expression • BAX expression
2d
The critical role and functional mechanism of microRNA-146a in doxorubicin-induced apoptosis in breast cancer cells. (PubMed, Nucleosides Nucleotides Nucleic Acids)
Considering the role of doxorubicin in inducing apoptosis and increasing the expression of miR-146a, it can be suggested that this miR is involved in inducing apoptosis in BC cells. In addition, miR-146a can be considered a therapeutic candidate.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • MIR146A (MicroRNA 146a)
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BCL2 expression • BAX expression • miR-146a expression
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doxorubicin hydrochloride
3d
n-Acetylcysteine protects against diazinon-induced histopathological damage and apoptosis in renal tissue of rats. (PubMed, Toxicol Res)
A significant increase was observed in mRNA expression of Bax, Caspase-3, Caspase-8, as well as TNF-α following exposure to DZN, but the expression of IL-10 and Bcl2 was significantly decreased. NAC can protect kidney tissue against DZN-induced toxicity by elevating antioxidants capacity, mitigating oxidative stress, inflammation and apoptosis.
Preclinical • Journal • IO biomarker
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TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CASP8 (Caspase 8) • CAT (Catalase)
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BCL2 expression • BAX expression
3d
leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) inhibits proliferation and promotes apoptosis of human HEL cells with JAK2 V617F mutation by blocking the JAK/STAT and PI3K/AKT signaling pathways (PubMed, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi)
In addition, LAIR-1 exhibited a significantly inhibitory effect on cell proliferation and promoted apoptosis in HEL cells. Conclusion In HEL cells with JAK2 V617F mutation, LAIR-1 can inhibit the activation of JAK/STAT and PI3K/AKT/mTOR signaling pathways by recruiting SHP-2, thereby inhibiting the proliferation of HEL cells and promoting cell apoptosis.
Journal • IO biomarker
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JAK2 (Janus kinase 2) • CCND1 (Cyclin D1) • STAT3 (Signal Transducer And Activator Of Transcription 3) • BAX (BCL2-associated X protein) • STAT1 (Signal Transducer And Activator Of Transcription 1) • ANXA5 (Annexin A5) • LAIR1 (Leukocyte Associated Immunoglobulin Like Receptor 1)
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BCL2 expression • CCND1 expression • JAK2 V617F • JAK2 mutation • BAX expression
4d
Withaferin A-Encapsulated PEGylated Nanoliposomes Induce Apoptosis in B16F10 Melanoma Cells by Regulating Bcl2 and Bcl xl Genes and Mitigates Murine Solid Tumor Development. (PubMed, J Environ Pathol Toxicol Oncol)
Also, LWA administration remarkably inhibited tumor cell proliferation by downregulating the expression of Ki-67 and Cyclin D1 and induced apoptosis by regulating the expression of Bax, Bcl2, and Bcl xl levels. Our results strongly suggest that LWA could be a promising therapeutic formulation for treating malignant melanoma.
Preclinical • Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • BCL2L1 (BCL2-like 1) • BAX (BCL2-associated X protein)
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BCL2 expression • CCND1 expression • BAX expression
5d
Demethylzeylasteral inhibits proliferation, migration and invasion and promotes apoptosis of non-small cell lung cancer cells by inhibiting the AKT/CREB signaling pathway (PubMed, Nan Fang Yi Ke Da Xue Xue Bao)
T-96 inhibits the proliferation, migration and invasion and induces apoptosis of NSCLC cells possibly by inhibiting the AKT/CREB signaling pathway.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • CDH1 (Cadherin 1) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • VIM (Vimentin) • CDH2 (Cadherin 2)
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BCL2 expression • CDH1 expression • BAX expression • VIM expression
5d
miR-515-5p targeting Toll-like receptor 4 regulates myeloid differentiation primary response gene 88/nuclear factor-kappa B pathway to inhibit apoptosis and inflammatory response of osteoarthritis chondrocytes (PubMed, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi)
Overexpression of TLR4 could partially reverse the effect of miR mimics on IL-1β-induced apoptosis and inflammation of OA chondrocytes. miR-515-5p negatively regulates the expression of TLR4, inhibits the activation of MyD88/NF-κB pathway and apoptosis of OA chondrocytes, and effectively alleviates the inflammatory response of the cells.
Journal • IO biomarker
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MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • TLR4 (Toll Like Receptor 4) • IL1B (Interleukin 1, beta) • RELA (RELA Proto-Oncogene)
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BCL2 expression • BAX expression • TLR4 overexpression
5d
Effects of electroacupuncture on the PI3K/Akt/CREB signaling pathway and hippocampal neuronal apoptosis in diabetic cognitive impairment rats. (PubMed, Zhen Ci Yan Jiu)
EA can improve the learning and memory abilities of rats with DCI, and the mechanism may be related to the regulation of the expression of PI3K/Akt/CREB signaling pathway-related proteins, which attenuates the neuronal apoptosis in the hippocampus of rats, and improves the neural function.
Preclinical • Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3)
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BCL2 expression • BAX expression
6d
Protective effect of ginsenoside Rb1 against aconitine cardiotoxicity studied by myocardial injury, action potential, and calcium signaling. (PubMed, Toxicon)
Rb1 reduced the cardiotoxicity of aconitine by attenuating aconitine-induced myocardial injury and inhibiting the aconitine-induced retardation of ventricular action potential and calcium signaling in rats.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3)
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BCL2 expression • BAX expression
6d
Investigation of apoptotic effects of Cucurbitacin D, I, and E mediated by Bax/Bcl-xL, caspase-3/9, and oxidative stress modulators in HepG2 cell line. (PubMed, Drug Dev Res)
Furthermore, cucurbitacins modulated oxidative stress by increasing TOS levels and decreasing SOD, GSH, TAS, and total and native Thiol levels. Our findings suggest that CuD, CuI, and CuE exert apoptotic effects on the hepatocellular carcinoma cell line by regulating Bax/Bcl-xL, caspase-3/9 signaling, and causing intracellular ROS increase in HepG2 cells.
Preclinical • Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • BCL2L1 (BCL2-like 1) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CASP9 (Caspase 9) • ANXA5 (Annexin A5)
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BAX expression
6d
circDDX17 targets miR-223-3p / RIP3 to regulate the proliferation and apoptosis of non-small cell lung cancer cells (PubMed, Zhonghua Zhong Liu Za Zhi)
Percentage of G0/G1 phase cells &lsqb;(56.64±2.76)%], apoptosis rate &lsqb;(8.34±0.76)%], the protein expression levels of cleaved caspase-3 and Bax in pcDNA-circDDX17+miR-223-3p group were lower than those of pcDNA-circDDX17+miR-con group &lsqb;(64.03±3.48)% and (15.21±1.18)%, respectively, P<0.05]. circDDX17 could inhibit the proliferation and induce apoptosis of non-small cell lung cancer cells via targeting the miR-223-3p / RIP3 molecular axis.
Journal
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CCND1 (Cyclin D1) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CDK2 (Cyclin-dependent kinase 2) • MIR223 (MicroRNA 223) • DDX17 (DEAD-Box Helicase 17)
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CCND1 expression • BAX expression • CDK2 expression
7d
Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells. (PubMed, Heliyon)
The protein expression levels of Bax and E-cadherin were up-regulated significantly, and the expression levels of BRAF, CyclinD1, Bcl-2, p-PI3K, p-AKT, and p-mTOR were markedly down-regulated with increasing concentrations of vemurafenib (P < 0.05). The proliferation and metastasis of FRO cells can be suppressed by vemurafenib through the silencing of BRAF and BANCR expression, inhibition of PI3K/AKT signaling pathway activation, induction of apoptosis, and cell cycle arrest.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • CDH1 (Cadherin 1) • BAX (BCL2-associated X protein)
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BRAF mutation • BCL2 expression • CCND1 expression • CDH1 expression • BAX expression
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Zelboraf (vemurafenib)
8d
Simultaneous suppression of miR-21 and restoration of miR-145 in gastric cancer cells; a promising strategy for inhibition of cell proliferation and migration. (PubMed, Bioimpacts)
This study provides evidence for the therapeutic possibility of the combination of miR-145-5p and anti-miR-21-5p and also suggests that they could inhibit cell proliferation by modulating the PTEN/AKT1 signaling pathway. Our research revealed that utilizing miR-145-5p and anti-miR-21-5p together could be a promising therapeutic approach for treating GC.
Journal • IO biomarker
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PTEN (Phosphatase and tensin homolog) • BCL2 (B-cell CLL/lymphoma 2) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • MIR21 (MicroRNA 21) • BAX (BCL2-associated X protein) • MMP9 (Matrix metallopeptidase 9) • MIR145 (MicroRNA 145)
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BCL2 expression • BAX expression
8d
Molecular properties prediction, anticancer and anti-inflammatory activities of some pyrimido[1,2-b]pyridazin-2-one derivatives. (PubMed, Bioimpacts)
Compound 1 also induced a statistically significant decrease in the gene expression of various cytokines and chemokines. These findings showed that the pyrimidine derivative 1 displayed potent anti-inflammatory and anticancer properties in vitro, and can be selected as a lead compound for further investigation.
Journal • IO biomarker
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TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • CCL2 (Chemokine (C-C motif) ligand 2) • IL1B (Interleukin 1, beta) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • CXCL3 (C-X-C Motif Chemokine Ligand 3)
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BCL2 expression • TP53 expression • BAX expression • PTGS2 expression
9d
Long non-coding RNA LINC01554 overexpression suppresses viability, migration, and invasion of liver cancer cells through regulating miR-148b-3p/EIF4E3. (PubMed, Heliyon)
Furthermore, the effects of miR-148b-3p knockdown on HCCLM3 cells were similar with those of LINC01554 overexpression, and miR-148b-3p mimics could reverse the changes of cell viability, apoptosis, migration, and invasion induced by LINC01554 overexpression. LINC01554 overexpression could suppress the growth and metastasis of HCCLM3 cells via miR-148b-3p/EIF4E3.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • CDH1 (Cadherin 1) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • MIR148B (MicroRNA 148b) • TIMP3 (TIMP Metallopeptidase Inhibitor 3)
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BAX expression
9d
Grape seed proanthocyanins protect fluoride-induced hepatotoxicity via the Nrf2 signaling pathway in male rats. (PubMed, Toxicol Res (Camb))
Taken together, GSPE exerts protective effects on the oxidative damage and apoptosis of fluoride-induced hepatic injury via the activation of the Nrf2 signaling pathway. This study provides a new perspective for the mechanism study and scientific prevention and treatment of liver injury induced by endemic fluorosis.
Preclinical • Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • CASP3 (Caspase 3)
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BAX expression
10d
Thymoquinone potentiates anti-cancer effects of cisplatin in oral squamous cell carcinoma via targeting oxidative stress. (PubMed, Chem Biol Drug Des)
In addition, the combination of thymoquinone and cisplatin modulated the mRNA and protein expression levels of apoptosis-related proteins including Bax, Bcl-2, and caspase-3. Thymoquinone potentiated cisplatin anti-cancer effect on OSCC by inducing oxidative stress in cells.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3)
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BAX expression
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cisplatin
10d
Evodiamine Inhibits Colorectal Cancer Growth via RTKs Mediated PI3K/AKT/p53 Signaling Pathway. (PubMed, J Cancer)
The possible mechanism of action is inhibiting the expression of the RTK protein family, activating the PI3K/AKT/p53 apoptotic signaling pathway, thereby inhibiting Bcl-2 expression and increasing Bax expression, promoting apoptosis of CRC cells. As a natural product, EVO has very high potential application value.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2)
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BCL2 expression • BAX expression
11d
Efficient assembly and anti-tumor evaluation of novel polycyclic [1,2-a]-fused indoles. (PubMed, Bioorg Chem)
Moreover, compound 4ae also exhibited promising antineoplastic efficacy in subcutaneous MCF-7 xenograft mice which manifest significant shrunken tumors conspicuous nuclear apoptotic signal and minimal systemic toxicity. This strategy not only established a novel and efficient method for the assembly of structurally complex indole heterocycles, but also provided a series of compounds possessing attractive anti-cancer activity, which holds immense potential for future biomedical applications.
Journal • PARP Biomarker • IO biomarker
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TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP9 (Caspase 9) • CCNB1 (Cyclin B1)
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BCL2 expression • TP53 expression • BAX expression
13d
Exploring pyrrolidinyl-spirooxindole natural products as promising platforms for the synthesis of novel spirooxindoles as EGFR/CDK2 inhibitors for halting breast cancer cells. (PubMed, Front Chem)
Remarkably, they demonstrated potent EGFR inhibition, with IC50 values of 0.026, 0.067, and 0.04 μM and inhibition percentages of 92.6%, 89.8%, and 91.2%, respectively, when compared to Erlotinib (IC50 = 0.03 μM, 95.4%). Furthermore, these compounds exhibited potent CDK-2 inhibition, with IC50 values of 0.301, 0.345, and 0.557 μM and inhibition percentages of 91.9%, 89.4%, and 88.7%, respectively, in contrast to Roscovitine (IC50 = 0.556 μM, 92.1%)...Treatment with 5g increased the gene expression of pro-apoptotic genes P53, Bax, caspases 3, 8, and 9 with notable fold changes while decreasing the expression of the anti-apoptotic gene Bcl-2. Molecular docking and dynamic simulations (100 ns simulation using AMBER22) were conducted to investigate the binding mode of the most potent candidates, namely, 5g, 5l, and 5n, within the active sites of EGFR and CDK-2.
Journal • IO biomarker
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TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP8 (Caspase 8) • CASP9 (Caspase 9)
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BCL2 expression • TP53 expression • BAX expression
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erlotinib • seliciclib (CYC202)
13d
Facile sonochemically-assisted bioengineering of titanium dioxide nanoparticles and deciphering their potential in treating breast and lung cancers: biological, molecular, and computational-based investigations. (PubMed, RSC Adv)
Molecular docking demonstrated strong binding interactions for TiO2 NPs with caspase 3 and EGFR-TK targets. In conclusion, the greenly synthesized TiO2 NPs exhibited potent antitumor activity and mitochondrion-based cell death against breast and lung cancer cell lines while maintaining cytocompatibility against normal cells.
Journal
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EGFR (Epidermal growth factor receptor) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3)
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BAX expression
13d
Effect of plasminogen activator urokinase receptor gene on the activation and apoptosis of neutrophil (PubMed, Zhonghua Yi Xue Za Zhi)
The relative expression of caspase-3 protein and bax protein (0.84±0.05, 0.83±0.04) in siRNA group was significantly higher than that in PBS group (0.68±0.02, 0.63±0.08) and NC group (0.71±0.01, 0.66±0.10) (P<0.05), and the relative expression of anti-apoptosis protein bcl-2 decreased in siRNA group (0.38±0.02) than in PBS group (0.73±0.05) and NC group (0.69±0.06) (P<0.05). PLAUR promotes the activation of neutrophil-like cells and inhibits the apoptosis.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • ITGAM (Integrin, alpha M) • IL17A (Interleukin 17A) • ANXA5 (Annexin A5) • PLAUR (Plasminogen Activator, Urokinase Receptor)
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BCL2 expression • BAX expression
13d
LncRNA SNHG11 promotes malignant progression of colorectal cancer cells through the PI3K/Akt/mTOR signaling pathway (PubMed, Zhonghua Yi Xue Za Zhi)
Phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signalling pathway inhibitor LY294002 was used for rescue experiments... LncRNA SNHG11 is highly expressed in colorectal cancer. lncRNA SNHG11 can promote the malignant progression of colorectal cancer cells by regulating the PI3K/Akt/mTOR signaling pathway, and this finding provides a new theoretical basis for targeted therapy of colorectal cancer.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • BCL2L1 (BCL2-like 1) • CDH1 (Cadherin 1) • BAX (BCL2-associated X protein) • VIM (Vimentin) • CDH2 (Cadherin 2) • MMP9 (Matrix metallopeptidase 9) • SNHG11 (Small Nucleolar RNA Host Gene 11)
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BCL2 expression • CDH1 expression • BAX expression • VIM expression
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LY294002
15d
A novel approach combining network pharmacology and experimental validation to study the protective effect of ginsenoside Rb1 against cantharidin-induced hepatotoxicity in mice. (PubMed, Basic Clin Pharmacol Toxicol)
In addition, results from animal studies demonstrated that GRb1 could ameliorate CTD-induced hepatotoxicity by inhibiting protein expression of Caspase-3, Caspase-8, Bcl-2/Bax, GRP78, ATF6, ATF4, CHOP, IRE1α and PERK. This research revealed the mechanism of GRb1 against CTD-induced hepatotoxicity by inhibiting apoptosis and endoplasmic reticulum stress (ERS) and it may provide a scientific rationale for the potential use of GRb1 in the treatment of hepatotoxicity induced by CTD.
Preclinical • Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • IL6 (Interleukin 6) • PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) • CASP3 (Caspase 3) • CASP8 (Caspase 8) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • IL17A (Interleukin 17A) • ATF4 (Activating Transcription Factor 4) • ATF6 (Activating Transcription Factor 6)
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BCL2 expression • BAX expression
15d
Anti-cancer effects of green synthesized gold nanoparticles using leaf extract of Annona muricata. L against squamous cell carcinoma cell line 15 through apoptotic pathway. (PubMed, Dent Res J (Isfahan))
Further, it also revealed a highly significant decrease in anti-apoptotic Bcl-2 gene expression, whereas pro-apoptotic genes p53 and Bax revealed a highly significant increase, which is statistically significant compared to the control (P < 0.05). Our findings demonstrated that the AuNPs synthesized from A. muricata leaf extract could act as a novel anticancer agent, particularly against SCC, after further scrutiny.
Preclinical • Journal • IO biomarker
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TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein)
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BCL2 expression • TP53 expression • BAX expression
16d
α‑Phellandrene enhances the apoptosis of HT‑29 cells induced by 5‑fluorouracil by modulating the mitochondria‑dependent pathway. (PubMed, Oncol Rep)
The mechanism by which apoptosis is induced may involve the intrinsic apoptosis pathway that activates the mitochondria‑dependent pathway, including regulating the expression levels of Bcl‑2 family members, including Bax, Bcl‑2 and Bid, regulating MMP and HK‑2 expression levels, and increasing the expression of caspase cascade molecules, including caspase‑9 and caspase‑3. In addition, it may involve the extrinsic apoptosis pathway that activates caspase‑8 and caspase‑3 leading to apoptosis.
Journal
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BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CASP8 (Caspase 8) • CASP9 (Caspase 9) • HK2 (Hexokinase 2)
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BCL2 expression • BAX expression
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5-fluorouracil
17d
Salvia officinalis L. exerts oncostatic effects in rodent and in vitro models of breast carcinoma. (PubMed, Front Pharmacol)
In vitro analyses revealed significant anti-cancer effects of SPGE extract in MCF-7 and MDA-MB-231 cell lines (cytotoxicity, caspase-3/-7, Bcl-2, Annexin V/PI, cell cycle, BrdU, and mitochondrial membrane potential). Our study demonstrates the significant chemopreventive and treatment effects of salvia haulm using animal or in vitro BC models.
Preclinical • Journal • IO biomarker
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PTEN (Phosphatase and tensin homolog) • BCL2 (B-cell CLL/lymphoma 2) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • MIR155 (MicroRNA 155) • EPCAM (Epithelial cell adhesion molecule) • MIR21 (MicroRNA 21) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • MIR34A (MicroRNA 34a-5p) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • TGFB1 (Transforming Growth Factor Beta 1) • CASP7 (Caspase 7) • MIR210 (MicroRNA 210) • RASSF1 (Ras Association Domain Family Member 1) • ANXA5 (Annexin A5) • MIR145 (MicroRNA 145) • MIR22 (MicroRNA 22) • TIMP3 (TIMP Metallopeptidase Inhibitor 3)
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BAX expression • CASP3 overexpression • BAX overexpression • EPCAM expression
18d
miR-16-5p aggravates sepsis-associated acute kidney injury by inducing apoptosis. (PubMed, Ren Fail)
Nevertheless, inhibition of miR-16-5p significantly attenuated this effect. In summary, up-regulation of miR-16-5p expression can significantly aggravate renal injury and apoptosis in S-AKI, which also proves that miR-16-5p can be used as a potential biomarker to promote early identification of S-AKI.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • KIM1 (Kidney injury molecule 1) • LCN2 (Lipocalin-2) • IL1B (Interleukin 1, beta) • MIR16 (MicroRNA 16)
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BCL2 expression • BAX expression
19d
Formononetin and Dihydroartemisinin Act Synergistically to Induce Apoptosis in Human Acute Myeloid Leukemia Cell Lines. (PubMed, Cell J)
The anti-leukemic potential of formononetin and dihydroartemisinin is exerted through the effect on cell cycle progression and intrinsic pathway of apoptosis. Therefore, they can be considered as a potential anti-leukemic agent alone or along with existing chemotherapeutic drugs.
Preclinical • Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • MCL1 (Myeloid cell leukemia 1) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3)
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CCND1 expression • BAX expression
20d
Optimizing combination therapy in prostate cancer: mechanistic insights into the synergistic effects of Paclitaxel and Sulforaphane-induced apoptosis. (PubMed, BMC Mol Cell Biol)
This combination therapy of PTX and SFN has the potential to improve prostate cancer treatment by minimizing side effects while maintaining efficacy. Mechanistic investigations revealed that SFN enhances PTX efficacy by promoting apoptosis, activating caspase-3, inducing nuclear morphology changes, modulating the cell cycle, and altering Bax and Bcl2 protein expression. These findings offer valuable insights into the synergistic effects of PTX and SFN, supporting the optimization of combination therapy and providing efficient therapeutic strategies in preclinical research.
Journal • Combination therapy • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3)
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BCL2 expression • BAX expression
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paclitaxel
20d
Investigation the apoptotic effect of silver nanoparticles (Ag-NPs) on MDA-MB 231 breast cancer epithelial cells via signaling pathways. (PubMed, Heliyon)
The migratory ability of MDA-MB-231 cells was reduced upon treatment with Ag-NPs. Our findings revealed that Ag-NPs influenced the proliferation, apoptosis, cell cycle, and migration in MDA-MB 231 cells, possibly by modulating protein expression of the AKT/ERK/Cyclin D1 axis.
Journal • IO biomarker
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PTEN (Phosphatase and tensin homolog) • BCL2 (B-cell CLL/lymphoma 2) • TERT (Telomerase Reverse Transcriptase) • CCND1 (Cyclin D1) • BAX (BCL2-associated X protein) • ANXA5 (Annexin A5)
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CCND1 expression • BAX expression
20d
Co-treatment with the seed of Carthamus tinctorius L. and the aerial part of Taraxacum coreanum synergistically suppresses Aβ25-35-induced neurotoxicity by altering APP processing. (PubMed, Food Sci Nutr)
Compared with the single herbs, co-treatment with CTS and TC markedly decreased the expression of Bax and increased the expression of Bcl-2, consistent with its anti-apoptotic effects. These findings suggest that co-treatment with CTS and TC may be useful for AD prevention.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • APP (Amyloid Beta Precursor Protein)
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BCL2 expression • BAX expression
21d
Prospective role of lusianthridin in attenuating cadmium-induced functional and cellular damage in rat thyroid. (PubMed, Heliyon)
Lusianthridin significantly altered the mRNA expression of Bcl-2, Bax, MEK1, ERK1, ERK2, p-eIf2α, GRP78, eIf2α, and GRP94. The results clearly state that Lusianthridin exhibits protective effects against thyroid cancer.
Preclinical • Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • MAP2K1 (Mitogen-activated protein kinase kinase 1) • MAPK1 (Mitogen-activated protein kinase 1) • BAX (BCL2-associated X protein) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • MAPK3 (Mitogen-Activated Protein Kinase 3)
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BCL2 expression • BAX expression
22d
Computational and in vitro analyses on synergistic effects of paclitaxel and thymoquinone in suppressing invasive breast cancer cells. (PubMed, Mol Biol Rep)
Effective concentrations of TQ and PTX had synergic effects and inhibited breast cancer cells via prompting apoptosis and autophagy in vitro.
Preclinical • Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • BECN1 (Beclin 1)
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BCL2 expression • BAX expression
|
paclitaxel
24d
Hesperidin Inhibits Oral Cancer Cell Growth via Apoptosis and Inflammatory Signaling-Mediated Mechanisms: Evidence From In Vitro and In Silico Analyses. (PubMed, Cureus)
Conclusion The cytotoxic effects on the KB cell line and its anti-inflammatory properties position hesperidin as a compelling candidate for further exploration in the quest for effective oral carcinoma treatments. These findings shed light on the intricate molecular mechanisms underlying hesperidin's promise as a therapeutic agent against oral carcinoma.
Preclinical • Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • BAX (BCL2-associated X protein) • IL1B (Interleukin 1, beta)
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BCL2 expression • BAX expression
25d
Highly in vitro anti-cancer activity of melittin-loaded niosomes on non-small cell lung cancer cells. (PubMed, Toxicon)
Melittin-loaded niosomes had more anti-cancer effects and less toxicity on normal cells than free melittin. Furthermore, it induced apoptosis and inhibited cancer cells migration. Our results showed that melittin-loaded niosomes may be a drug lead and it has the potential to be future developed for lung cancer treatment.
Preclinical • Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3)
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BCL2 expression • BAX expression
26d
Anticancer Action of Silver Nanoparticles in SKBR3 Breast Cancer Cells through Promotion of Oxidative Stress and Apoptosis. (PubMed, Biomed Res Int)
Findings also indicated that AgNPs suppress the expression of genes (VEGF-A, AKT, and PI3K) involved in angiogenesis. Altogether, our data revealed that AgNPs initiate oxidative stress and apoptosis in SKBR3 breast cancer cells, dose dependently.
Journal • IO biomarker
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BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • PI3K (Phosphoinositide 3-kinases)
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BCL2 expression • BAX expression • VEGFA expression
27d
Characterization of BCL-XL, MCL-1, and BAX Protein Expression in Response to Neoadjuvant Chemotherapy in Breast Cancer. (PubMed, Appl Immunohistochem Mol Morphol)
There was no statistically significant association between the expression of these markers and stage, grade, and hormone receptor profiling (luminal status). Collectively, our data indicate that the expression of apoptosis regulatory proteins changes following exposure to NAC in breast cancer tissue, developing a partial pathologic response.
Journal
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MCL1 (Myeloid cell leukemia 1) • BCL2L1 (BCL2-like 1) • BAX (BCL2-associated X protein)
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MCL1 expression • BAX expression
27d
Prohibitin 1 inhibits cell proliferation and induces apoptosis via the p53-mediated mitochondrial pathway in vitro. (PubMed, World J Gastrointest Oncol)
PHB1 inhibits human HCC cell viability by arresting the cell cycle and inducing cell apoptosis via activation of the p53-mediated mitochondrial pathway.
Preclinical • Journal • IO biomarker
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TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • CCNE1 (Cyclin E1) • AFP (Alpha-fetoprotein) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CCNA2 (Cyclin A2) • CDK2 (Cyclin-dependent kinase 2) • CASP9 (Caspase 9) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
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TP53 expression • BAX expression • CDK2 expression
28d
Overexpression of miR-506-3p reversed doxorubicin resistance in drug-resistant osteosarcoma cells. (PubMed, Front Pharmacol)
Overexpression of miR-506-3p could inhibit the JAK2/STAT3 pathway and the malignant biological behaviors, then further reverse doxorubicin resistance in drug-resistant osteosarcoma cells. The study reported a new molecular mechanism for reversing the resistance of osteosarcoma to doxorubicin chemotherapy and provided theoretical support for solving the clinical problems of doxorubicin resistance in osteosarcoma.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • ABCB1 (ATP Binding Cassette Subfamily B Member 1) • BIRC5 (Baculoviral IAP repeat containing 5) • ABCC1 (ATP Binding Cassette Subfamily C Member 1) • BAX (BCL2-associated X protein) • MIR506 (MicroRNA 506)
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BIRC5 expression • STAT3 expression • BAX expression • STAT3 overexpression
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doxorubicin hydrochloride