Basal Cell Carcinoma

CDKN2A and PCTH1 mutations, frequently detected in melanoma and basal cell carcinoma, respectively, were detected in the second case. The presence of 2 components with distinct immunoprofile yet with some common genetic aberration suggests that basomelanocytic tumors may arise from a common progenitor.

P2, N=16, Completed, Melanoma Institute Australia | Recruiting --> Completed | Trial completion date: Jun 2026 --> Mar 2025 | Trial primary completion date: Jun 2026 --> Mar 2025

Further, pharmacokinetic studies in mice revealed improved plasma disposition, higher AUC, and slower elimination for Lipo/GlaB compared to the free drug. These findings support the therapeutic value of Lipo/GlaB as a selective and potent strategy for targeting HH-dependent cancers, offering improved biopharmaceutical properties and in vivo efficacy compared to non-formulated GlaB.

P2, N=27, Not yet recruiting, Mayo Clinic

In addition, comparative analyses revealed conserved gene signatures in human basal cell carcinoma of the eyelids, emphasizing the importance of canine models in translational oncology. This comprehensive molecular characterization provides new insights into the pathogenesis of canine eyelid melanoma and identifies key biomarkers and pathways that may be relevant for future therapeutic interventions in veterinary and comparative oncology.

In this review, we present the current therapeutic opportunities and future directions of immunotherapy in the management of malignant melanoma, cutaneous squamous cell carcinoma, basal cell carcinoma, and Merkel cell carcinoma, accompanied by a brief overview of their mechanisms of action. Ambrus L, Balatoni T. Immunotherapy of cutaneous neoplasms.

As Professor Sydney Gellis remarked, 'When he gets down to the ovaries, he's gone about as far as he can go', capturing Gorlin's expansive curiosity and expertise. As well as the legacy of the syndromes he has been associated with, he has left a blueprint for all clinical colleagues to take forward in their daily practice - empathy, humour and generosity of spirit.

Elevated risk for the development of SC has been identified with underlying immunosuppression, as seen in similar studies. Histopathological examination remains crucial for accurate diagnosis and management.

Although the term 'rodent ulcer' has largely been replaced by 'basal cell carcinoma', the historical term still appears in some clinical and historical contexts. This evolution reflects broader trends in medicine, transitioning from symptom-based descriptors to molecularly informed classifications, marking the ongoing development of medical science.

S100, SOX10, neurofilament and desmin are typically negative. While perineuriomas behave in a benign fashion, complete surgical excision is recommended.

HPV8 AKs were more prevalent in immunosuppressed patients (odds ratio 3.33, P = 0.05); however, immunosuppression did not add to the risk of subsequent SCC. Immunosuppression greatly increases the risk of HPV8-associated AKs and therefore KC.

Gli2-dominant Hh overexpression was seen in the tumour plus stroma of eyelid morphoeic but not nodular BCC. FLNB is a potential tumour suppressor, with its loss producing a morphoeic phenotype in vitro.