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BIOMARKER:

BAP1 negative

i
Other names: BAP1, BRCA1 Associated Protein 1, BRCA1 Associated Protein-1 (Ubiquitin Carboxy-Terminal Hydrolase), Ubiquitin Carboxyl-Terminal Hydrolase BAP1, Cerebral Protein 6, Ubiquitin Carboxy-Terminal Hydrolase, BRCA1-Associated Protein 1, Cerebral Protein-13, HUCEP-13, KIAA0272, Hucep-6, UCHL2
Entrez ID:
Related biomarkers:
2ms
Prognostic Value of BAP1 Protein Expression in Uveal Melanoma. (PubMed, Am J Surg Pathol)
nBAP1 protein expression proved to be a more reliable prognostic indicator for OS than the American Joint Committee on Cancer staging, M3 status, or The Cancer Genome Atlas classification in this cohort. This study provides support for accurate prognostication of UM patients in routine histology laboratories by immunohistochemistry for nBAP1 alone.
Journal
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BAP1 (BRCA1 Associated Protein 1)
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BAP1 negative
10ms
In Vitro Testing of the Virus-Like Drug Conjugate Belzupacap Sarotalocan (AU-011) on Uveal Melanoma Suggests BAP1-Related Immunostimulatory Capacity. (PubMed, Invest Ophthalmol Vis Sci)
The in vitro cytotoxicity was accompanied by exposure of DAMPs (HSP90 and CRT), suggesting AU-011 may contribute to the development of systemic immunity and be a suitable candidate for combination with immunotherapy in vivo. AU-011 treatment was more effective against BAP1-positive cell lines, with a lower EC50 and higher CRT exposure.
Preclinical • Journal
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BAP1 (BRCA1 Associated Protein 1) • CALR (Calreticulin) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1)
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BAP1 negative
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belzupacap sarotalocan (AU-011)
10ms
Diffuse intrapulmonary mesothelioma mimicking pulmonary lepidic adenocarcinoma: a rare case report and review of the literature. (PubMed, Diagn Pathol)
The final diagnosis was DIM. In conclusion, we should recognize this rare disease to avoid misdiagnosis and delayed treatment.
Review • Journal
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CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • MTAP (Methylthioadenosine Phosphorylase) • BAP1 (BRCA1 Associated Protein 1) • WT1 (WT1 Transcription Factor) • NKX2-1 (NK2 Homeobox 1)
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CDKN2A negative • BAP1 negative
11ms
Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities. (PubMed, J Pathol)
Some of these molecules were able to impact tumour cell viability, and carvedilol, an adrenergic receptor antagonist, restored PLIN2 levels, mimicking the expression of normoxia/lipid storage signatures and reversing the expression of hypoxia/lipolysis signatures in co-cultures of uveal melanoma cells with human macrophages...Some of these molecules were able to impact tumour cells viability, and carvedilol, an adrenergic receptor antagonist, restored PLIN2 levels, mimicking the expression of normoxia/lipid storage signatures and reversing the expression of hypoxia/lipolysis signatures in co-cultures of uveal melanoma cells with human macrophages. These findings open a new research line for understanding the lipid metabolic regulation of immune responses, with implications for therapeutic innovation in uveal melanoma.
Journal
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BAP1 (BRCA1 Associated Protein 1) • PLIN2 (Perilipin)
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BAP1 negative • PLIN2 expression
1year
BAP1 loss is associated with higher ASS1 expression in epithelioid mesothelioma: implications for therapeutic stratification. (PubMed, Mol Cancer Res)
Alterations in arginine metabolism may sensitise cells to metabolic drugs and we find that BAP1-negative/ASS1-expressing MPM cell lines are more sensitive to ASS1 inhibition, although not to inhibition of purine synthesis by mizoribine. Importantly, BAP1w-/KO MeT5A become desensitised to arginine-deprivation by pegylated arginine deiminase (ADI-PEG20), phenocopying BAP1-negative/ASS1-expressing MPM cell lines. Implications: Our data reveal an inter-relationship between BAP1 and arginine metabolism, providing a potential means of identifying epithelioid MPM patients likely to benefit from ADI-PEG20.
Journal • BRCA Biomarker
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BRCA1 (Breast cancer 1, early onset) • BAP1 (BRCA1 Associated Protein 1) • ASS1 (Argininosuccinate synthase 1)
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BAP1 mutation • ASS1 negative • BAP1 negative
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Bredinin (mizoribine) • Hepacid (pegargiminase)
over1year
High C-Reactive Protein Levels Are Related to Better Survival in Patients with Uveal Melanoma. (PubMed, Ophthalmol Sci)
Higher CRP levels were associated with a longer MFS in the entire cohort. Neither the NLR nor the LMR is a good predictor for metastasis developing in patients with UM.
Journal
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BAP1 (BRCA1 Associated Protein 1) • CRP (C-reactive protein)
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BAP1 negative
almost2years
Vascular Lakes in Uveal Melanoma and Their Association With Outcome. (PubMed, Transl Vis Sci Technol)
Digital analysis of UM can be easily performed to assess various prognostic parameters. Our pilot study demonstrates that UM-VL could be combined with other parameters to determine metastatic risk of patients with UM.
Retrospective data • Journal
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BAP1 (BRCA1 Associated Protein 1)
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BAP1 negative
almost2years
BAP1 Immunostain Status in Intraocular Biopsy Specimens for Uveal Melanoma Highly Correlates with Other Prognostic Markers. (PubMed, Ocul Oncol Pathol)
Among BAP1-negative UM patients, 2 were alive (1 with metastatic disease) and 3 had melanoma-related deaths. BAP1 immunostaining in biopsies highly correlates with results in subsequent enucleations and with well-established UM prognostic markers, representing a potential additional prognostic tool for UM biopsies.
Journal
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BAP1 (BRCA1 Associated Protein 1)
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BAP1 negative
over2years
BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma. (PubMed, J Biol Chem)
These results suggest that BAP1 and YY1 cooperatively repress transcription of TRAIL receptors. Our finding that BAP1 directly regulates the extrinsic apoptotic pathway will provide new insights into the role of BAP1 in the development of MPM and other cancers with frequent BAP1 mutations.
Journal • BRCA Biomarker
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BRCA1 (Breast cancer 1, early onset) • BAP1 (BRCA1 Associated Protein 1) • TNFRSF10B (TNF Receptor Superfamily Member 10b)
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BAP1 mutation • BAP1 negative
almost3years
Targeting the YAP/TAZ Pathway in Uveal and Conjunctival Melanoma With Verteporfin. (PubMed, Invest Ophthalmol Vis Sci)
Although most UM cell lines responded in vitro to VP, BAP1-negative and conjunctival melanoma cell lines did not. Not only the mutational background, but also cell growth rate is an important predictor of response to YAP/TAZ inhibition by VP.
Journal
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BRAF (B-raf proto-oncogene) • NRAS (Neuroblastoma RAS viral oncogene homolog) • GNAQ (G Protein Subunit Alpha Q) • BAP1 (BRCA1 Associated Protein 1) • YAP1 (Yes associated protein 1)
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BRAF mutation • NRAS mutation • BAP1 mutation • BAP1 negative • YAP1 overexpression
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Visudyne (verteporfin)
3years
Rucaparib in patients with BAP1-deficient or BRCA1-deficient mesothelioma (MiST1): an open-label, single-arm, phase 2a clinical trial. (PubMed, Lancet Respir Med)
Rucaparib in patients with BAP1-negative or BRCA1-negative mesothelioma met the prespecified criteria for success, showing promising activity with manageable toxicity. Further investigation of homologous recombination deficiency mutations is planned to refine the identification of predictive biomarkers for PARP inhibition in mesothelioma.
Clinical • P2a data • Journal • BRCA Biomarker • PARP Biomarker
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BRCA1 (Breast cancer 1, early onset) • HRD (Homologous Recombination Deficiency) • BAP1 (BRCA1 Associated Protein 1)
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BRCA1 mutation • HRD • HRD + BRCA1 mutation • BAP1 negative
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Rubraca (rucaparib)