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    GENE:

    BAG4 (BAG Cochaperone 4)

    i
    Other names: BAG4, BAG Cochaperone 4, Silencer Of Death Domains, SODD, BAG Family Molecular Chaperone Regulator 4, Bcl-2-Associated Athanogene 4, BCL2 Associated Athanogene 4, BAG-4
    5ms
    Pan-cancer analysis of the oncogenic role of ZNF703 in regulating tumor immunity. (PubMed, BMC Cancer)
    Notably, ZNF703, DDHD2, LSM1, and BAG4 are co-localized within the amplicons at the chromosome 8p11-p12 region, indicating a potential cooperative role in driving cancer initiation and progression. Collectively, these findings underscore the essential roles of ZNF703 in cancer development, patient prognosis, and the regulation of anti-tumor immunity, highlighting its potential as a biomarker for cancer detection and as a novel immunotherapeutic target.
    Journal • IO biomarker • Pan tumor
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    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • ICAM1 (Intercellular adhesion molecule 1) • BAG4 (BAG Cochaperone 4) • CXCL3 (C-X-C Motif Chemokine Ligand 3) • ZNF703 (Zinc Finger Protein 703)
    6ms
    Expression Analysis, Diagnostic Significance and Biological Functions of BAG4 in Acute Myeloid Leukemia. (PubMed, Medicina (Kaunas))
    It may play an important role in leukemogenesis by affecting apoptotic resistance and immune evasion. BAG4 has potential as a diagnostic biomarker and treatment target in AML, but further in vivo and clinical validation is needed.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • TNFRSF1A (TNF Receptor Superfamily Member 1A) • BAG1 (BAG Cochaperone 1) • BAG4 (BAG Cochaperone 4)
    8ms
    Anoikis classification of lung squamous cell carcinoma reveals correlation with clinical prognosis and immune characteristics. (PubMed, Ann Med)
    ARGs, especially SNAI1, play an essential role in developing LUSC. These findings could provide individualized treatment plans and new research ideas for LUSC patients.
    Journal
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    FADD (Fas associated via death domain) • BAG4 (BAG Cochaperone 4) • SNAI1 (Snail Family Transcriptional Repressor 1)
    10ms
    In Vivo Evaluation of Pam2Cys-Modified Cancer-Testis Antigens as Potential Self-Adjuvanting Cancer Vaccines. (PubMed, J Pept Sci)
    Herein, we explore the synthesis of two tissue-restricted cancer-testis antigens (CTAs); New York oesophageal cell carcinoma 1 (NY-ESO-1) and B melanoma antigen 4 (BAGE4), both carrying the toll-like receptor (TLR) agonist, Pam2Cys. These constructs were evaluated in vivo along with a lipid nanoparticle (LNP) preparation of the underexplored BAGE4 melanoma antigen.
    Preclinical • Journal
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    CTAG1B (Cancer/testis antigen 1B) • BAG4 (BAG Cochaperone 4)
    10ms
    USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer. (PubMed, Mol Med)
    The study highlights the USP14/BAG4/PRKN axis as a critical pathway in CRC (MSI-H), suggesting that targeting USP14 could inhibit tumor progression and improve chemotherapeutic outcomes. These findings underscore the importance of ubiquitination and mitophagy in cancer biology, indicating a potential therapeutic target for MSI-H CRC.
    Journal • Microsatellite instability • MSi-H Biomarker • MSI-H
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    MSI (Microsatellite instability) • BAG4 (BAG Cochaperone 4) • USP14 (Ubiquitin Specific Peptidase 14)
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    MSI-H/dMMR
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    oxaliplatin
    11ms
    Construction and Validation of T-cell Exhaustion-related Gene Signature for Predicting Prognosis in Diffuse Large B-cell Lymphoma. (PubMed, Curr Pharm Biotechnol)
    The TEX score has prognosis-predicting value for DLBCL and might be a valuable biomarker to guide clinical decision-making for patients with DLBCL.
    Journal • Gene Signature • IO biomarker
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    BIRC3 (Baculoviral IAP repeat containing 3) • BAG4 (BAG Cochaperone 4) • TRIM6 (Tripartite Motif Containing 6)
    over1year
    Amplicon 8p11.2-p12-based prediction of survival in breast cancer patients – is FGFR1 the driver gene? (ECP 2024)
    In breast cancer, the 8p11.2-p12 amplicon shows clinically relevant gene expression profiles which could serve as potential targets for precision medicine in breast cancer patients. Moreover, the identified 7-gene minimal amplicon could be used as prognostic predictor for long-term survival.
    Clinical
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    FGFR1 (Fibroblast growth factor receptor 1) • EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1) • BAG4 (BAG Cochaperone 4) • ZNF703 (Zinc Finger Protein 703)
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    HR positive • FGFR1 amplification • FGFR1 expression
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    Prosigna™ Breast Cancer Prognostic Gene Signature Assay
    2years
    Annexin A7 and Its Related Protein Suppressor of Death Domains Regulates Migration and Proliferation of Hca-P Cells. (PubMed, Cell J)
    SODD expression was decreased with the down-regulation of ANXA7. Down-regulating ANXA7 in Hca-P cells decreased proliferation, migration and invasion of tumor cells.
    Journal
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    BAG4 (BAG Cochaperone 4) • ANXA7 (Annexin A7)
    2years
    Lessons of Nature in Trisomy-8 MDS and AML: Determinants of Clonal Drive (ASH 2023)
    8 itself. Indeed, we found transcriptomic changes pertinent to +8 MDS whose role in driving leukemogenesis and interaction with specific myeloid drivers needs to be confirmed by future experimentations on cellular and murine models.
    IO biomarker
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    FLT3 (Fms-related tyrosine kinase 3) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • NPM1 (Nucleophosmin 1) • DNMT3A (DNA methyltransferase 1) • RUNX1 (RUNX Family Transcription Factor 1) • SF3B1 (Splicing Factor 3b Subunit 1) • ASXL1 (ASXL Transcriptional Regulator 1) • SRSF2 (Serine and arginine rich splicing factor 2) • U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1) • CEBPA (CCAAT Enhancer Binding Protein Alpha) • STAG2 (Stromal Antigen 2) • LYN (LYN Proto-Oncogene Src Family Tyrosine Kinase) • NSD3 (Nuclear Receptor Binding SET Domain Protein 3) • BAG4 (BAG Cochaperone 4) • PVT1 (Pvt1 Oncogene) • LY96 (Lymphocyte Antigen 96)
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    FLT3 mutation • DNMT3A mutation • RUNX1 mutation • U2AF1 mutation • STAG2 mutation
    over2years
    Downregulation of SODD mediates carnosol-induced reduction in cell proliferation in esophageal adenocarcinoma cells. (PubMed, Sci Rep)
    Carnosol's effect may be through the overproduction of ROS and the downregulation of SODD. Carnosol might be useful for the treatment of esophageal adenocarcinoma.
    Journal
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    CASP3 (Caspase 3) • BAG4 (BAG Cochaperone 4)
    almost3years
    SODD Promotes Lung Cancer Tumorigenesis by Activating the PDK1/AKT and RAF/MEK/ERK Signaling. (PubMed, Genes (Basel))
    SODD is overexpressed in lung tissues and plays a considerable role in the development and progression of lung cancer by regulating the PI3K/PDK1/AKT and RAF/MEK/ERK pathways.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • RAF1 (Raf-1 Proto-Oncogene Serine/Threonine Kinase) • BAG1 (BAG Cochaperone 1) • BAG4 (BAG Cochaperone 4) • PDPK1 (3-Phosphoinositide dependent protein kinase 1)
    3years
    Gene Expression Profile as a Therapeutic Biomarker for Classic Hodgkin Lymphoma Treated with Immunotherapy-Based Regimens (USCAP 2023)
    Background : PD-1 blockade treatment with nivolumab is effective in relapsed/refractory Classic Hodgkin Lymphoma (CHL)... IL13 and IL15 modulation may be a logical objective for future therapeutic strategies since their role in proliferation of HL-derived cell-lines in addition to JAK-STAT and MAPK signaling activation. Likewise, SOCS3 for its suppressive role in JAK-STAT pathway. Other dysregulated genes in our series with potential therapeutic targets should be SMAD7, FADD, NFKB1, and MAPK11due to their involvement in variety of process including cell growth and differentiation, apoptosis as well as immune response .
    PD(L)-1 Biomarker • Gene Expression Profile • IO biomarker
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    MAP2K1 (Mitogen-activated protein kinase kinase 1) • CCND1 (Cyclin D1) • PIK3CD (Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta) • HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1) • IL2 (Interleukin 2) • IL7R (Interleukin 7 Receptor) • S100A8 (S100 Calcium Binding Protein A8) • FADD (Fas associated via death domain) • MAPK1 (Mitogen-activated protein kinase 1) • ROR2 (Receptor Tyrosine Kinase Like Orphan Receptor 2) • S100A9 (S100 Calcium Binding Protein A9) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • CCL2 (Chemokine (C-C motif) ligand 2) • HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1) • TNFRSF4 (TNF Receptor Superfamily Member 4) • IL1A (Interleukin 1, alpha) • IL32 (Interleukin 32) • MLANA (Melan-A) • BAG4 (BAG Cochaperone 4) • CCL22 (C-C Motif Chemokine Ligand 22) • CDC20 (Cell Division Cycle 20) • CTSL (Cathepsin L) • ERCC6 (Excision repair cross-complementation group 6) • IL13 (Interleukin 13) • IL15 (Interleukin 15) • IL22 (Interleukin 22) • SMAD7 (SMAD Family Member 7) • ST6GAL1 (ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1) • CD80 (CD80 Molecule) • CDCA8 (Cell Division Cycle Associated 8) • CDK3 (Cyclin Dependent Kinase 3) • CENPA (Centromere protein A) • HNF1A (HNF1 Homeobox A) • IFNL3 (Interferon Lambda 3) • IRAK1 (Interleukin 1 Receptor Associated Kinase 1) • KIF4A (Kinesin Family Member 4A) • KLRB1 (Killer Cell Lectin Like Receptor B1) • LGALS9 (Galectin 9) • MAGEA1 (MAGE Family Member A1) • MAGEC2 (MAGE Family Member C2) • MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4) • MAPK11 (Mitogen-Activated Protein Kinase 11) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA) • PATZ1 (POZ/BTB And AT Hook Containing Zinc Finger 1) • PDHA1 (Pyruvate Dehydrogenase E1 Subunit Alpha 1) • POU2AF1 (POU Class 2 Homeobox Associating Factor 1) • SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A) • SOCS3 (Suppressor Of Cytokine Signaling 3) • TGFBR1 (Transforming Growth Factor Beta Receptor 1) • TGIF2 (TGFB Induced Factor Homeobox 2)
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    HTG EdgeSeq Precision Immuno-Oncology Panel
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    Opdivo (nivolumab)