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    GENE:

    BAG1 (BAG Cochaperone 1)

    i
    Other names: BAG1, BAG Cochaperone 1, BAG Family Molecular Chaperone Regulator 1, BCL2 Associated Athanogene 1, BAG-1, HAP, Glucocortoid Receptor-Associated Protein RAP46, Bcl-2 Associating Athanogene-1 Protein, Receptor-Associated Protein, 46-KD, Bcl-2-Associated Athanogene 1, BCL2 Associated Athanogene, BCL2-Associated Athanogene, Bcl-2-Binding Protein, RAP46
    27d
    Alterations in the transcriptional profile of genes in tumors as a prerequisite for personalization of treatment in breast cancer patients (PubMed, Arkh Patol)
    Comparative mRNA expression analysis confirms that a short preoperative course of aromatase inhibitors induces a more potent and uniform molecular response, characterized by profound suppression of proliferation and complete inhibition of estrogen-dependent signaling. Tamoxifen therapy is also effective but results in less pronounced suppression of key targets and, crucially, may be accompanied by early activation of the MYC oncogene, a potential marker for resistance development.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • ER (Estrogen receptor) • PGR (Progesterone receptor) • PTEN (Phosphatase and tensin homolog) • BCL2 (B-cell CLL/lymphoma 2) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CCND1 (Cyclin D1) • CCNE1 (Cyclin E1) • FGFR4 (Fibroblast growth factor receptor 4) • BIRC5 (Baculoviral IAP repeat containing 5) • TYMS (Thymidylate Synthetase) • AURKA (Aurora kinase A) • FOXA1 (Forkhead Box A1) • PPP2R2A (Protein Phosphatase 2, Regulatory Subunit B, Alpha) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • BAG1 (BAG Cochaperone 1) • EMSY (EMSY Transcriptional Repressor BRCA2 Interacting) • GATA3 (GATA binding protein 3) • KRT5 (Keratin 5) • MMP11 (Matrix Metallopeptidase 11) • MYBL2 (MYB Proto-Oncogene Like 2) • SFRP1 (Secreted frizzled related protein 1) • TMEM45B (Transmembrane Protein 45B) • ANLN (Anillin Actin Binding Protein) • CCNB1 (Cyclin B1) • SCGB2A2 (Secretoglobin Family 2A Member 2) • ZNF703 (Zinc Finger Protein 703)
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    HER-2 negative • HER-2 expression
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    tamoxifen • letrozole • anastrozole
    2ms
    Liver-specific BAG3 knockout delays chemically induced hepatocellular carcinoma development. (PubMed, FEBS J)
    Proteomic analysis of DEN-induced acute liver injury revealed alterations in key pathways in BAG3albKO mice livers, including inhibition of autophagy and increased liver necrosis. Collectively, these findings emphasize the complex role of BAG3 in HCC pathogenesis and indicate its participation in tumor onset and progression.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • BAG1 (BAG Cochaperone 1)
    2ms
    BAG6 promotes hepatocellular carcinoma growth via enhancing PLK1-mediated aerobic glycolysis. (PubMed, Int J Biol Macromol)
    Mechanistically, BAG6 directly binds to PLK1 and suppresses its ubiquitination and degradation, and enhances PLK1-mediated Warburg effect, thereby promoting HCC growth. Overall, we identify BAG6 as an HCC progression driver via the PLK1-mediated Warburg effect, a potential therapeutic and early screening marker.
    Journal • Tumor mutational burden • IO biomarker
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    TMB (Tumor Mutational Burden) • BCL2 (B-cell CLL/lymphoma 2) • PLK1 (Polo Like Kinase 1) • BAG1 (BAG Cochaperone 1)
    2ms
    Identification and characterization of peptidyl-prolyl isomerase Pin1 as a new regulatory component of BCR::ABL1 degradation. (PubMed, Leuk Res)
    Pin1 may convert the mature form BCR::ABL1 to an immature form for Bag1 recognition leading to CHIP-mediated ubiquitination and degradation. These findings may lead to provide a molecular basis for the development of new Pin1 related therapeutic strategies against TKI resistance.
    Journal
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    ABL1 (ABL proto-oncogene 1) • BAG1 (BAG Cochaperone 1)
    4ms
    Circular SNX25 encoded radioresistance augmenter facilitates DNA damage repair in hepatocellular carcinoma by targeting BAG6-GET4 interaction. (PubMed, Cell Death Dis)
    Our findings highlight the potential of circSNX25 as a prognostic biomarker and a therapeutic target for overcoming radioresistance in HCC. This study provides deeper insights into the roles that circRNA-encoded proteins play in HCC radioresistance.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • BAG1 (BAG Cochaperone 1)
    4ms
    HSPB1 silencing enhances ferroptosis in glioma cells by suppressing BAG3 expression. (PubMed, Am J Transl Res)
    HSPB1 inhibits ferroptosis and promotes glioma cell survival, at least in part through BAG3 upregulation. Targeting the HSPB1-BAG3 axis may represent a novel therapeutic strategy and prognostic approach in glioma treatment.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • BAG1 (BAG Cochaperone 1) • HSPB1 (Heat shock 27kDa protein 1)
    5ms
    Genome-Wide Identification and Expression Analysis of BAG Family in Sweet Potato and Its Two Diploid Relatives. (PubMed, Int J Mol Sci)
    The results suggested that homologous BAGs have differentiated functions and play various vital roles in plant growth, tuberous root development, and abiotic and biotic stress response in sweet potato and its two diploid relatives. This work provides a comprehensive comparison and understanding of the BAG genes in sweet potato and its two diploid relatives, supplying a theoretical foundation for their functional study and further facilitating the molecular breeding of sweet potato.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • BAG1 (BAG Cochaperone 1)
    6ms
    Expression Analysis, Diagnostic Significance and Biological Functions of BAG4 in Acute Myeloid Leukemia. (PubMed, Medicina (Kaunas))
    It may play an important role in leukemogenesis by affecting apoptotic resistance and immune evasion. BAG4 has potential as a diagnostic biomarker and treatment target in AML, but further in vivo and clinical validation is needed.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • TNFRSF1A (TNF Receptor Superfamily Member 1A) • BAG1 (BAG Cochaperone 1) • BAG4 (BAG Cochaperone 4)
    7ms
    Mechanistic insights into promotion of non-small cell lung cancer by BAG5 using integrative multi-omics approaches. (PubMed, Front Immunol)
    These findings underscore the potential oncogenic role of BAG5 in NSCLC, revealing that it acts through multiple molecular pathways. Our study suggests that targeting BAG5 could be a promising therapeutic strategy for treating NSCLC.
    Journal
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    BCL2 (B-cell CLL/lymphoma 2) • BAG1 (BAG Cochaperone 1)
    7ms
    Targeting the BAG2/CHIP axis promotes gastric cancer apoptosis by blocking apoptosome assembly. (PubMed, Front Immunol)
    Furthermore, we screened FIIN-2, an inhibitor of the BAG2 complex, which effectively halts the malignant development of GC triggered by reduced apoptosis by blocking BAG-CHIP binding. In conclusion, this study highlights BAG2's key role in regulating apoptosis and confirms FIIN-2's effectiveness in GC-targeted therapy.
    Journal
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    BCL2 (B-cell CLL/lymphoma 2) • BAG1 (BAG Cochaperone 1) • APAF1 (Apoptotic peptidase activating factor 1)
    7ms
    PKCζ regulates autophagy in pancreatic ductal adenocarcinoma via BAG3: a novel therapeutic vulnerability. (PubMed, Biochem Pharmacol)
    Furthermore, PKCζ inhibition enhances the anti-tumor efficacy of other chemotherapeutic agents, such as mitogen-activated protein kinase kinase (MEK) inhibitors, in PDAC. These findings identify PKCζ as a promising therapeutic target and provide a foundation for the development of innovative treatment strategies for pancreatic cancer.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • BAG1 (BAG Cochaperone 1) • BECN1 (Beclin 1)
    8ms
    METTL21A promotes hepatocellular carcinoma progression via methylating and stabilizing BAG3. (PubMed, NPJ Precis Oncol)
    Notably, we discovered that the natural compound sophoricoside (Sop) acts as a METTL21A inhibitor and exhibits potent anti-HCC activity. Our study not only elucidates the oncogenic role and molecular mechanism of METTL21A in HCC progression but also highlights its therapeutic potential as a novel drug target for HCC treatment.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • BAG1 (BAG Cochaperone 1) • TRIM21 (Tripartite Motif Containing 21)