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    BIOMARKER:

    BAG1 overexpression

    i
    Other names: BAG1, BAG Cochaperone 1, BAG Family Molecular Chaperone Regulator 1, BCL2 Associated Athanogene 1, BAG-1, HAP, Glucocortoid Receptor-Associated Protein RAP46, Bcl-2 Associating Athanogene-1 Protein, Receptor-Associated Protein, 46-KD, Bcl-2-Associated Athanogene 1, BCL2 Associated Athanogene, BCL2-Associated Athanogene, Bcl-2-Binding Protein, RAP46
    Entrez ID:
    573
    2years
    CRISPR/Cas9-mediated Bag-1 knockout increased mesenchymal characteristics of MCF-7 cells via Akt hyperactivation-mediated actin cytoskeleton remodeling. (PubMed, PLoS One)
    A potent Akt inhibitor, MK-2206, suppressed mesenchymal transition in Bag-1 KO cells. Similar results were obtained following the recovery of Bag-1 isoforms (Bag-1S, M, or L) in Bag-1 KO cells. The findings of this study emphasized that Bag-1 is a mediator of actin-mediated cytoskeleton organization through regulating Akt activation.
    Journal
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    BAG1 (BAG Cochaperone 1)
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    BAG1 overexpression
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    MK-2206