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GENE:

AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding)

News alerts, weekly reports and conference planners

Entinostat suppresses hepatocellular carcinoma metastasis by upregulating AZGP1 through histone acetylation. (PubMed, Biochem Pharmacol)

In conclusion, our work elucidates a coherent epigenetic pathway wherein entinostat activates AZGP1 to inhibit HCC metastasis. These findings nominate AZGP1 as both a critical mediator and a potential biomarker for entinostat-based therapy in advanced HCC.

1 month ago

Journal

TGFB1 (Transforming Growth Factor Beta 1) • AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding)

Jingzhuda (entinostat)

3ms

Loss of EHMT2 enhances NK cell-driven anti-tumor immunity through TGF-β1 suppression. (PubMed, EMBO Mol Med)

Furthermore, EHMT2 and TGF-β1 inhibitors suppressed tumors in immunocompetent, but not in immunodeficient mice. These findings establish EHMT2 as a suppressor of NK cell-mediated anti-tumor immunity and a promising therapeutic target.

3 months ago

Journal

TGFB1 (Transforming Growth Factor Beta 1) • AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding) • NKG2D (killer cell lectin like receptor K1)

6ms

Spatial gene expression profiling identifies prognostic features of residual tumors after neoadjuvant chemotherapy in triple-negative breast cancer. (PubMed, Front Oncol)

We identified some differentially expressed genes relevant to oncogenic signaling and immunosuppressive tumor-associated macrophages. These findings provide novel insights into factors affecting prognosis in patients with residual disease after NAC for early-stage TNBC.

6 months ago

Journal

ACTA2 (Actin Alpha 2 Smooth Muscle) • S100A9 (S100 Calcium Binding Protein A9) • CHI3L1 (Chitinase 3-like 1) • HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1) • KRT14 (Keratin 14) • COL3A1 (Collagen Type III Alpha 1 Chain) • IFI27 (Interferon Alpha Inducible Protein 27) • AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding) • MMP7 (Matrix metallopeptidase 7) • MYLK (Myosin Light Chain Kinase) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1) • SERPINA3 (Serpin Family A Member 3) • TPM2 (Tropomyosin 2) • RPL22 (Ribosomal Protein L22)

6ms

Transcriptomic Profile of Perineural Invasion in Prostate Cancer Identifies Prognostic Gene Signatures. (PubMed, Biomedicines)

A high mRNA expression level of AZGP1 was associated with longer disease-free survival, whereas high mRNA expressions of ASPN, COMP, RYR2, and SFRP4 were associated with shorter disease-free survival. Prostate cancer patients with genomic alterations associated with PNI may face a higher risk of disease progression after prostatectomy, highlighting the need for further prospective studies to validate these findings.

6 months ago

Journal • Gene Signature

ER (Estrogen receptor) • MUC1 (Mucin 1) • CLDN1 (Claudin 1) • KRT19 (Keratin 19) • AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding) • COMP (Cartilage Oligomeric Matrix Protein) • SFRP4 (Secreted frizzled-related protein 4)

7ms

Integrated analysis of scRNA-seq and bulk RNA-seq data reveals the key targets of the combination of cisplatin and saikosaponin D in gastric cancer cells. (PubMed, Biochem Biophys Res Commun)

Additionally, the levels of the phosphorylated forms of FAK, AKT, and mTOR were significantly reduced in both AGS/DDP and SGC-7901/DDP cells treated with the combination of DDP and SSD, whereas the PTEN expression level increased. Our findings highlight the importance of alternative components within the tumor microenvironment for GC therapy and identify FAK/AKT/mTOR signaling as a potential target of SSD, providing novel insights into the mechanism by which SSD improves DDP resistance in GC.

7 months ago

Journal

EGFR (Epidermal growth factor receptor) • ER (Estrogen receptor) • PTEN (Phosphatase and tensin homolog) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • SPP1 (Secreted Phosphoprotein 1) • FXYD3 (FXYD Domain Containing Ion Transport Regulator 3) • AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding) • SNCG (Synuclein Gamma)

cisplatin

7ms

AZGP1: A proteomic biomarker in cancer. (PubMed, Clin Chim Acta)

We propose a plan that includes the development of reference standards, conducting large prospective trials within biobank networks, and using artificial intelligence to discover combined proteomic signatures of the disease. These efforts aim to establish serum AZGP1 as a reliable, minimally invasive biomarker that improves early detection, prognostic stratification, and informs precision oncology.

7 months ago

Review • Journal

CEACAM5 (CEA Cell Adhesion Molecule 5) • AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding)

9ms

Lipidomics reveals effect of EHHADH in lung squamous cell. (PubMed, Cell Biol Toxicol)

In conclusion, EHHADH functions as an important regulator of lipid metabolism in LUSC and plays a key role in the occurrence, progression, and treatment of lung cancer. The important impact of EHHADH in lipid metabolism disorders suggests potential utility as a biomarker for diagnosis and a target for personalized treatment strategies in lung cancer.

9 months ago

Journal

CAV1 (Caveolin 1) • CYP3A4 (Cytochrome P450, family 3, subfamily A, polypeptide 4) • RARG (Retinoic Acid Receptor Gamma) • AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding)

9ms

Zinc-alpha-2-glycoprotein overexpression and maintaining anti-apoptotic function in oral squamous cell carcinoma. (PubMed, Arch Oral Biol)

HPV oncoproteins and high doses of arecoline are risk factors for an overexpressed ZAG protein that has an anti-apoptotic function in OSCC.

9 months ago

Journal • IO biomarker

TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • STAT3 (Signal Transducer And Activator Of Transcription 3) • NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) • AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding)

11ms

Taurine and proline promote lung tumour growth by co-regulating Azgp1/mTOR signalling pathway. (PubMed, NPJ Precis Oncol)

These findings underscore the pro-cancer role of taurine and proline, highlighting the Azgp1/mTOR axis as a vital, yet overlooked, pathway in lung cancer. This study not only advances our understanding but also identifies new therapeutic avenues.

11 months ago

Journal

AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding)

11ms

A case-control prospective study to unravel zinc alpha 2 glycoprotein role in the pathophysiology of diabetic retinopathy. (PubMed, Int Ophthalmol)

The present study shows that ZAG is increased in the vitreous and aqueous humour of the PDR cases compared to the macular hole. It was also correlated with the already reported biomarkers. It could be a risk factor for the disease based on the odds ratio.

11 months ago

Journal

AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding) • LEP (Leptin)