^
    3years
    FAT10 stimulates the development of osteosarcoma by regulating the JAK/STAT signaling pathway. (PubMed, J BUON)
    FAT10 is upregulated in OS samples, which stimulates the development of OS by activating the JAK/STAT signaling pathway.
    Journal
    |
    IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • STAT3 (Signal Transducer And Activator Of Transcription 3)
    |
    AZ 960
    over3years
    High MMP-11 expression associated with low CD8+ T cells decreases the survival rate in patients with breast cancer. (PubMed, PLoS One)
    We found that pictilisib and AZ960 effectively inhibited the breast cancer cell lines with high MMP-11 expression. Strategies making use of MMP-11-related hub genes could contribute to better clinical management/research for patients with breast cancer.
    Clinical • Journal
    |
    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
    |
    pictilisib (GDC-0941) • AZ 960