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DRUG:

AVB-001

i
Other names: AVB-001, hIL-2 IP, AVB-001 IP
Company:
Avenge Bio, Rice University
Drug class:
IL-2 stimulant
Related drugs:
7ms
A Study of Intraperitoneally Administered AVB-001 in Patients With Serous Adenocarcinoma of the Ovary (clinicaltrials.gov)
P1/2, N=14, Terminated, Avenge Bio, Inc | Trial completion date: Aug 2026 --> Apr 2024 | Active, not recruiting --> Terminated | Trial primary completion date: Aug 2026 --> Apr 2024; Sponsor Decision to close study
Trial completion date • Trial termination • Trial primary completion date
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BRCA (Breast cancer early onset)
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BRCA mutation
|
AVB-001
8ms
A Study of Intraperitoneally Administered AVB-001 in Patients With Serous Adenocarcinoma of the Ovary (clinicaltrials.gov)
P1/2, N=14, Active, not recruiting, Avenge Bio, Inc | Recruiting --> Active, not recruiting | N=44 --> 14
Enrollment closed • Enrollment change
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BRCA (Breast cancer early onset)
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BRCA mutation
|
AVB-001
almost2years
Enrollment open
|
BRCA (Breast cancer early onset)
|
BRCA mutation
|
AVB-001
2years
Favorable preclinical efficacy and safety profile of AVB-001 a novel IL-2 cell-based immunotherapy that eradicates ovarian cancer in mouse tumor models and supports first in human clinical development (SITC 2022)
Background Aldesleukin, recombinant human IL-2 has been approved by the FDA for the treatment of melanoma and renal cancer. Avenge Bio aims to pursue a Phase 1 First in Human study of AVB-001 in ovarian cancer patients. The LOCOcyte TM platform enables delivery of a diverse set of cytokines alone or in combination which is presently being explored.
P1 data • Preclinical • IO biomarker
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IL2 (Interleukin 2)
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Proleukin (aldesleukin) • AVB-001
2years
New P1/2 trial
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BRCA (Breast cancer early onset)
|
BRCA mutation
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AVB-001