AURKA (Aurora kinase A)

SP-2-067 is a novel, selective AKA degrader that modulates IC expression by upregulating PD-L1 and downregulating LAG3, indicating its potential for immunomodulation through AUNIP- and NINEIN-mediated mechanisms. Additionally, AKA, AUNIP, and NINEIN are linked to a distinct immune cell profile, presenting an opportunity to reshape the tumor immune microenvironment and support combinatorial strategies with IC inhibitors in prostate cancer.

Importantly, TRPV1 expression correlated positively with cancer stem cell markers in both murine models and human samples. Collectively, our results reveal that TRPV1 is not only overexpressed in PCa but also contributes to proliferation regulation and stemness features, positioning it as a potential diagnostic and prognostic biomarker for prostate cancer.

This integrative multi-scale analysis reveals complex proliferation-associated gene expression patterns and substantial cellular heterogeneity within hepatocellular carcinoma. STMN1 and RRM2 emerge as dominant markers of proliferative reprogramming and promising candidate therapeutic targets warranting further functional investigation in HCC progression.

Sabinene also showed favorable binding to aurora A (-9.964 kcal/mol) but was less active toward PTEN. These findings suggested that EGEO possesses promising antioxidant and anticancer properties, with limonene emerging as a potential multitarget therapeutic agent for oxidative stress-related and proliferative disorders.

Effect size estimates were relatively large for both the group effect (partial η2=0.20) and the time x group interaction (partial η2=0.24), suggesting that the study may have been underpowered to detect this difference statistically. In conclusion, the present exploratory study suggests that suramin exerts a dual antitumor effect on tongue squamous cell carcinoma by suppressing proliferative transcriptional programs, and modulating extracellular and stress response pathways, providing a basis for future studies to further elucidate its therapeutic relevance.

Here, we show that the KRAS G12C inhibitor LY3499446 induces CIN in KRAS -mutant NSCLC cell lines...In the presence of Aurora Kinase A inhibition, cyclin B1 stabilization delays mitotic exit and diverts cell fate from mitotic slippage or division toward mitotic catastrophe. Together, our findings identify CIN as a predictive marker of response to combined KRAS G12C and Aurora Kinase A inhibition, providing mechanistic rationale to enhance the therapeutic window of AURKA inhibitors when used with targeted therapies.

Nicotinamide metabolism was found to be significantly linked with EC progression. This study offers new perceptions into the role of nicotinamide metabolism in EC and suggests possible avenues for treatment advancements.

Thus, clarifying these alternate mechanisms may be important as the roles of cilia in tumor formation and propagation, angiogenesis, and treatment resistance are increasingly reported. A deeper understanding of the role of cilia in these hallmarks of glioma may hold clues to the high recurrence rate of GBM.

Our findings demonstrate that CEP55 enhances PCa progression by stimulating the TPX2/AURKA/PI3K/AKT signaling pathway and inhibiting ferroptosis. Targeting this axis may represent a potential therapeutic approach for PCa.

This study provides a mechanistic hypothesis for 6PPD-Q-induced testicular dysfunction and offers candidate targets for future experimental validation in environmental reproductive toxicology.

However, concerns remain regarding CB's toxicity profile at high doses. This review emphasizes the therapeutic potential of CB in HCC treatment and advocates for further translational research to optimize its clinical applicability, dosage, and safety.